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Note 1 - Nature of the Business and Basis of Presentation (Details Textual)
$ in Thousands
9 Months Ended 12 Months Ended
Sep. 30, 2023
USD ($)
Sep. 30, 2022
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Number of Operating Segments 1   1    
Retained Earnings (Accumulated Deficit) $ (270,285)   $ (222,815) $ (186,174)  
Net Cash Provided by (Used in) Operating Activities (36,132) $ (54,763) (68,462) (28,439) $ (11,174)
Cash and Cash Equivalents, at Carrying Value $ 30,971   $ 76,528 $ 8,533