<SEC-DOCUMENT>0001567619-21-015934.txt : 20210816
<SEC-HEADER>0001567619-21-015934.hdr.sgml : 20210816
<ACCEPTANCE-DATETIME>20210816171648
ACCESSION NUMBER:		0001567619-21-015934
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20210812
FILED AS OF DATE:		20210816
DATE AS OF CHANGE:		20210816

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Waddill William D.
		CENTRAL INDEX KEY:			0001553338

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39402
		FILM NUMBER:		211179822

	MAIL ADDRESS:	
		STREET 1:		C/O CALITHERA BIOSCIENCES
		STREET 2:		343 OYSTER POINT BLVD, SUITE 200
		CITY:			SO. SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Annexon, Inc.
		CENTRAL INDEX KEY:			0001528115
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				275414423
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		180 KIMBALL WAY
		STREET 2:		SUITE 200
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		(650)-822-5500

	MAIL ADDRESS:	
		STREET 1:		180 KIMBALL WAY
		STREET 2:		SUITE 200
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>doc1.xml
<DESCRIPTION>FORM 3
<TEXT>
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<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2021-08-12</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001528115</issuerCik>
        <issuerName>Annexon, Inc.</issuerName>
        <issuerTradingSymbol>ANNX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001553338</rptOwnerCik>
            <rptOwnerName>Waddill William D.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ANNEXON, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>180 KIMBALL WAY, SUITE 200</rptOwnerStreet2>
            <rptOwnerCity>SOUTH SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94080</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <remarks>Exhibit 24.1 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Jennifer Lew, as Attorney-in-Fact for William D. Waddill</signatureName>
        <signatureDate>2021-08-16</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24.1
<SEQUENCE>2
<FILENAME>poa_waddill.htm
<DESCRIPTION>POWER OF ATTORNEY
<TEXT>
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    <div style="text-align: center; margin-bottom: 12pt; font-size: 12pt; font-weight: bold;">POWER OF ATTORNEY</div>
    <div style="text-indent: 36pt;">Know all by these presents, that the undersigned hereby constitutes and appoints each of (i) the Chief Executive Officer of Annexon, Inc.,
      a Delaware corporation (the &#8220;<font style="font-weight: bold;">Company</font>&#8221;), who is currently Douglas Love, Esq., and (ii) the Company&#8217;s Chief Financial Officer, who is currently
      Jennifer Lew, and their respective successors, signing singly, with full power of substitution, as the undersigned&#8217;s true and lawful attorney-in-fact to:</div>
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          <td style="width: 36pt; vertical-align: top; align: right;">(1)</td>
          <td style="width: auto; vertical-align: top;">
            <div>execute for and on behalf of the undersigned, in the undersigned&#8217;s capacity as an officer and/or director of the Company, Forms&#160;3, 4 and 5 (including amendments
              thereto) in accordance with Section&#160;16(a) of the Securities Exchange Act of 1934 and the rules and regulations thereunder and a Form ID, Uniform Application for Access Codes to File on EDGAR;</div>
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          <td style="width: 36pt; vertical-align: top; align: right;">(2)</td>
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            <div>do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Forms 3, 4 or 5 or Form ID and
              timely file such forms (including amendments thereto) and application with the United States Securities and Exchange Commission and any stock exchange or similar authority; and</div>
          </td>
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          <td style="width: 36pt; vertical-align: top; align: right;">(3)</td>
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            <div>take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest
              of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and
              conditions as such attorney-in-fact may approve in such attorney-in-fact&#8217;s discretion.</div>
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    </table>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing
      whatsoever requisite, necessary or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or
      revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted.&#160; The
      undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned's responsibilities to comply with Section&#160;16 of the
      Securities Exchange Act of 1934.</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">The undersigned agrees that each such attorney-in-fact herein may rely entirely on information furnished orally or in writing by the
      undersigned to such attorney-in-fact.&#160; The undersigned also agrees to indemnify and hold harmless the Company and each such attorney-in-fact against any losses, claims, damages or liabilities (or actions in these respects) that arise out of or are
      based upon any untrue statements or omission of necessary facts in the information provided by the undersigned to such attorney-in fact for purposes of executing, acknowledging, delivering or filing Forms 3, 4 or 5 (including amendments thereto) or
      Form ID and agrees to reimburse the Company and such attorney-in-fact for any legal or other expenses reasonably incurred in connection with investigating or defending against any such loss, claim, damage, liability or action.</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">This Power of Attorney supersedes any power of attorney previously executed by the undersigned regarding the purposes outlined in the first
      paragraph hereof (&#8220;<font style="font-weight: bold; font-style: italic;">Prior Powers of Attorney</font>&#8221;), and the authority of the attorneys-in-fact named in any Prior Powers of Attorney
      is hereby revoked.</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Forms&#160;3, 4 or 5 with
      respect to the undersigned's holdings of and transactions in securities issued by the Company, unless earlier (a)&#160;revoked by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact or (b)&#160;superseded by a new power of attorney
      regarding the purposes outlined in the first paragraph hereof dated as of a later date.</div>
    <div><br>
    </div>
    <div>IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 2nd day of August, 2021.</div>
    <div><br>
    </div>
    <div style="margin-left: 279pt; margin-top: 12pt;"><u>/s/ William D. Waddill</u><font style="display: inline-block; text-indent: 0px; font-size: 1px; width: 189pt" id="TRGRRTFtoHTMLTab">&#160;</font></div>
    <div style="text-indent: 279pt;">William D. Waddill</div>
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</SEC-DOCUMENT>
