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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Operating activities:    
Net loss $ (38,676) $ (35,373)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 536 518
Accretion of premium (discount) on available-for-sale securities (902) 380
Stock-based compensation 4,607 4,252
Reduction in the carrying amount of right-of-use assets 264 230
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 1,070 383
Other assets (12) (241)
Accounts payable 3,035 1,785
Accrued liabilities (2,771) (1,860)
Operating lease liabilities (348) (412)
Other current liabilities 204 50
Net cash used in operating activities (32,993) (30,288)
Investing activities:    
Purchases of property and equipment (137) (5,214)
Purchases of available-for-sale securities (31,435) (5,935)
Proceeds from maturities of available-for-sale securities 51,089 79,400
Net cash provided by investing activities 19,517 68,251
Financing activities:    
Proceeds from the exercise of common stock options 111 19
Proceeds from the issuance of common stock to a related party, net of commissions 17,545  
Payment of common stock issuance costs (75)  
Net cash provided by financing activities 17,581 19
Increase in cash, cash equivalents and restricted cash 4,105 37,982
Effect of exchange rate changes on cash, cash equivalents and restricted cash (5) 3
Cash, cash equivalents and restricted cash    
Beginning of period 141,052 76,009
End of period 145,152 113,994
Supplemental disclosure of cash flow information:    
Cash paid for amounts included in the measurement of lease liability 1,175 1,135
Non-cash investing and financing activities:    
Purchases of property and equipment included in accounts payable and accrued liabilities $ 5 $ 801