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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2023
Jun. 30, 2022
Operating activities:    
Net loss $ (73,864) $ (72,510)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,072 1,058
Accretion of (discount) premium on available-for-sale securities (1,695) 601
Stock-based compensation 9,267 8,772
Reduction in the carrying amount of right-of-use assets 538 469
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 818 1,200
Other assets   (1,018)
Accounts payable (152) 2,669
Accrued liabilities (4,495) 736
Operating lease liabilities (844) (454)
Other current liabilities (19) 25
Net cash used in operating activities (69,374) (58,452)
Investing activities:    
Purchases of property and equipment (167) (6,075)
Purchases of available-for-sale securities (69,875) (27,632)
Proceeds from maturities of available-for-sale securities 95,090 121,667
Net cash provided by investing activities 25,048 87,960
Financing activities:    
Proceeds from the exercise of common stock options 111 19
Proceeds from Employee Stock Purchase Plan purchases 345 113
Proceeds from the issuance of common stock to a related party, net of commissions 17,545  
Payment of common stock issuance costs (75)  
Net cash provided by financing activities 17,926 132
(Decrease) increase in cash, cash equivalents and restricted cash (26,400) 29,640
Effect of exchange rate changes on cash, cash equivalents and restricted cash (6) (3)
Cash, cash equivalents and restricted cash    
Beginning of period 141,052 76,009
End of period 114,646 105,646
Supplemental disclosure of cash flow information:    
Cash paid for amounts included in the measurement of lease liability 2,350 1,892
Non-cash investing and financing activities:    
Deferred offering costs included in accrued liabilities   704
Purchases of property and equipment included in accounts payable and accrued liabilities $ 7 $ 93