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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Operating activities:    
Net loss $ (106,346) $ (107,564)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,610 1,576
Accretion of (discount) premium on available-for-sale securities (2,290) 490
Stock-based compensation 13,816 13,683
Reduction in the carrying amount of right-of-use assets 823 717
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 1,543 (280)
Other assets   (204)
Accounts payable (2,503) (777)
Accrued liabilities (2,958) 4,041
Operating lease liabilities (1,350) (883)
Other current liabilities (10) 31
Net cash used in operating activities (97,665) (89,170)
Investing activities:    
Purchases of property and equipment (186) (6,244)
Purchases of available-for-sale securities (83,612) (46,364)
Proceeds from maturities of available-for-sale securities 156,684 154,666
Net cash provided by investing activities 72,886 102,058
Financing activities:    
Proceeds from the exercise of common stock options 111 64
Proceeds from Employee Stock Purchase Plan purchases 345 113
Proceeds from the issuance of common stock to a related party, net of commissions 17,545  
Payment of common stock issuance costs (75)  
Proceeds from the issuance of common stock, pre-funded warrants and common warrants in private placement   120,976
Proceeds from the issuance of common stock, pre-funded warrants and common warrants in private placement - related party   9,500
Payment of common stock, pre-funded warrants and common warrants issuance costs related to private placement   (7,853)
Net cash provided by financing activities 17,926 122,800
(Decrease) increase in cash, cash equivalents and restricted cash (6,853) 135,688
Effect of exchange rate changes on cash, cash equivalents and restricted cash (8) (7)
Cash, cash equivalents and restricted cash    
Beginning of period 141,052 76,009
End of period 134,191 211,690
Supplemental disclosure of cash flow information:    
Cash paid for amounts included in the measurement of lease liability 3,525 3,028
Non-cash investing and financing activities:    
Purchases of property and equipment included in accounts payable and accrued liabilities $ 6 $ 118