<SEC-DOCUMENT>0000895345-23-000169.txt : 20230217
<SEC-HEADER>0000895345-23-000169.hdr.sgml : 20230217
<ACCEPTANCE-DATETIME>20230217160029
ACCESSION NUMBER:		0000895345-23-000169
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20230217
DATE AS OF CHANGE:		20230217

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Annexon, Inc.
		CENTRAL INDEX KEY:			0001528115
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				275414423
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91583
		FILM NUMBER:		23642354

	BUSINESS ADDRESS:	
		STREET 1:		1400 SIERRA POINT PARKWAY
		STREET 2:		BLDG C, SUITE 200
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005
		BUSINESS PHONE:		(650)-822-5500

	MAIL ADDRESS:	
		STREET 1:		1400 SIERRA POINT PARKWAY
		STREET 2:		BLDG C, SUITE 200
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Satter Muneer A
		CENTRAL INDEX KEY:			0001315797

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	MAIL ADDRESS:	
		STREET 1:		C/O SATTER INVESTMENT MANAGEMENT, LLC
		STREET 2:		676 NORTH MICHIGAN AVENUE, SUITE 4000
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60611
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>ff1779507_13da1_satter.htm
<TEXT>
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      <div style="text-align: center; font-family: 'Times New Roman', serif; font-size: 18pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; font-family: 'Times New Roman', serif; font-size: 18pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; font-family: 'Times New Roman', serif; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
      <div style="text-align: center; font-family: 'Times New Roman', serif; font-size: 12pt; font-weight: bold;">
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          <div>&#160;
            <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
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        <div style="margin-top: 12pt; font-size: 18pt; font-weight: bold;">SCHEDULE 13D</div>
        <div style="font-weight: bold;">(Rule 13d-101)</div>
        <div style="font-weight: bold;">Under the Securities Exchange Act of 1934</div>
        <div style="font-weight: bold;">(Amendment No. 1)</div>
        <div style="margin-top: 12pt; font-size: 10pt; font-weight: bold;">INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT</div>
        <div style="font-size: 10pt; font-weight: bold;">TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED</div>
        <div style="margin-bottom: 10pt; font-size: 10pt; font-weight: bold;">PURSUANT TO RULE 13d-2(a)</div>
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      <br>
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        <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
      <div style="text-align: center; margin-top: 6pt; font-family: 'Times New Roman', serif; font-size: 22pt; font-weight: bold;">Annexon, Inc.</div>
      <div style="text-align: center; font-family: 'Times New Roman', serif; font-weight: bold;">(Name of issuer)</div>
      <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;
        <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
      <div style="text-align: center; margin-top: 6pt; font-family: 'Times New Roman', serif; font-weight: bold;">Common Stock, par value $0.001</div>
      <div style="text-align: center; font-family: 'Times New Roman', serif; font-size: 8pt; font-weight: bold;">(Title of class of securities)</div>
      <div style="text-align: center; margin-top: 6pt; font-family: 'Times New Roman', serif; font-weight: bold;">03589W102</div>
      <div style="text-align: center; font-family: 'Times New Roman', serif; font-size: 8pt; font-weight: bold;">(CUSIP number)</div>
      <div style="text-align: center; margin-top: 6pt; font-family: 'Times New Roman', serif; font-weight: bold;">Muneer A. Satter</div>
      <div style="text-align: center; font-family: 'Times New Roman', serif; font-weight: bold;">c/o Alerce Investment Management, L.P.</div>
      <div style="text-align: center; font-family: 'Times New Roman', serif; font-weight: bold;">676 N. Michigan Avenue, Suite 4000, Chicago, IL 60611</div>
      <div style="text-align: center; font-family: 'Times New Roman', serif; font-weight: bold;">(312) 448-5500
        <div style="font-size: 12pt;">
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      <div style="text-align: center; font-family: 'Times New Roman', serif; font-weight: bold;"> <br>
      </div>
      <div style="margin: 0px 0px 0px; font-family: 'Times New Roman', serif; font-weight: bold; text-align: center;">February 10, 2023</div>
      <div style="text-align: center; font-family: 'Times New Roman', serif; font-size: 8pt; font-weight: bold;">(Date of Event which Requires Filing of this Statement)</div>
      &#160;
      <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">
        <hr noshade="noshade" align="center" style="height: 2px; width: 20%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"><br>

        <div><br>
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      </div>
      <div><br>
      </div>
      <div style="margin-top: 6pt; font-family: 'Times New Roman', serif;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is
        filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box.&#160;&#160;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
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              <div style="font-family: 'Times New Roman', serif;">*</div>
            </td>
            <td style="width: 96%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', serif;">The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities,
                and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.</div>
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      <div style="margin-top: 6pt; font-family: 'Times New Roman', serif;">The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section&#160;18 of the Securities
        Exchange Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
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        <div style="text-align: center; font-family: 'Times New Roman', serif;">SCHEDULE 13D</div>
        <div style="font-family: 'Times New Roman', serif; font-size: 6pt;">&#160;</div>
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                <div style="font-family: 'Times New Roman', serif;">CUSIP No. 03589W102</div>
              </td>
              <td style="width: 10%; vertical-align: bottom;">
                <div style="font-family: 'Times New Roman', serif;">&#160;&#160;</div>
              </td>
              <td style="width: 45%; vertical-align: top;">
                <div style="text-align: right; font-family: 'Times New Roman', serif;">Page 2 of 5<br>
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                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">1</div>
              </td>
              <td colspan="3" style="BORDER-TOP: #000000 1pt solid; VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">NAMES OF REPORTING PERSONS</div>
              </td>
              <td style="BORDER-TOP: #000000 1pt solid; VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-TOP: #000000 1pt solid; BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="text-align: left; font-family: 'Times New Roman', serif; font-size: 12pt;">Muneer A. Satter</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr style="HEIGHT: 13px">
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">2</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: right">(a)</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: middle; PADDING-RIGHT: 2px; WIDTH: 5.01%">
                <div style="FONT-FAMILY: ''Times New Roman''; TEXT-ALIGN: left">&#9744;</div>
              </td>
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              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">&#160;</td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: right">(b)</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: middle; PADDING-RIGHT: 2px; WIDTH: 5.01%">
                <div style="FONT-FAMILY: ''Times New Roman''; TEXT-ALIGN: left">&#9744;</div>
              </td>
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                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
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              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">3</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%; BACKGROUND-COLOR: #bfbfbf">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SEC USE ONLY</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%; BACKGROUND-COLOR: #bfbfbf">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%; BACKGROUND-COLOR: #bfbfbf">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
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            <tr style="BACKGROUND-COLOR: #bfbfbf">
              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
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            <tr style="BACKGROUND-COLOR: #bfbfbf">
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">4</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SOURCE OF FUNDS (SEE INSTRUCTIONS)</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
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              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="text-align: left; font-family: 'Times New Roman', serif; font-size: 12pt;">OO</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
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              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">5</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: middle; PADDING-RIGHT: 2px; WIDTH: 5.01%">
                <div style="FONT-FAMILY: ''Times New Roman''; TEXT-ALIGN: left">&#9744;</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">&#160;</td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">6</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="text-align: left; font-family: 'Times New Roman', serif; font-size: 12pt;">United States of America</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td colspan="2" rowspan="12" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; FONT-WEIGHT: bold; BORDER-LEFT: #000000 1pt solid; WIDTH: 12.71%">
                <div style="TEXT-ALIGN: center">NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH</div>
              </td>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">7</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SOLE VOTING POWER</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                <div style="text-align: left; font-family: 'Times New Roman', serif; font-size: 12pt;">
                  <div>7,679,521</div>
                </div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">8</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SHARED VOTING POWER</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                <div style="text-align: left; font-family: 'Times New Roman', serif; font-size: 12pt;">0 shares</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">9</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SOLE DISPOSITIVE POWER</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                <div style="text-align: left; font-family: 'Times New Roman', serif; font-size: 12pt;">
                  <div>7,679,521</div>
                </div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">10</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SHARED DISPOSITIVE POWER</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                <div style="text-align: left; font-family: 'Times New Roman', serif; font-size: 12pt;">0 shares</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">11</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="text-align: left; font-family: 'Times New Roman', serif; font-size: 12pt;">
                  <div>7,679,521</div>
                </div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">12</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: middle; PADDING-RIGHT: 2px; WIDTH: 5.01%">
                <div style="FONT-FAMILY: ''Times New Roman''; TEXT-ALIGN: left">&#9744;</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">&#160;</td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">13</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="text-align: left; font-family: 'Times New Roman', serif; font-size: 12pt;">15.0%</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">14</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                <div style="text-align: left; font-family: 'Times New Roman', serif; font-size: 12pt;">IN</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
        <div><br>
        </div>
        <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div class="BRPFPageBreak" style="page-break-after: always;">
            <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
        </div>
        <div>
          <div>
            <div style="text-align: center; font-family: 'Times New Roman', serif;">SCHEDULE 13D</div>
            <div style="font-family: 'Times New Roman', serif; font-size: 6pt;">&#160;</div>
            <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 45%; vertical-align: middle;">&#160;</td>
                  <td style="width: 10%; vertical-align: bottom;">&#160;</td>
                  <td style="width: 45%; vertical-align: middle;">&#160;</td>
                </tr>
                <tr>
                  <td style="width: 45%; vertical-align: top;">
                    <div style="font-family: 'Times New Roman', serif;">CUSIP No. 03589W102</div>
                  </td>
                  <td style="width: 10%; vertical-align: bottom;">
                    <div style="font-family: 'Times New Roman', serif;">&#160;&#160;</div>
                  </td>
                  <td style="width: 45%; vertical-align: top;">
                    <div style="text-align: right; font-family: 'Times New Roman', serif;">Page 3 of 5<br>
                    </div>
                  </td>
                </tr>

            </table>
          </div>
          <div><br>
          </div>
        </div>
        <div><br>
        </div>
        <div>
          <table cellspacing="0" cellpadding="0" id="ze2b65d67aa204216a98e892c1b9549e3" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

              <tr>
                <td style="width: 99.94%; vertical-align: top;" colspan="3">
                  <div style="text-align: justify; font-family: 'Times New Roman', serif;">This Amendment No. 1 (&#8220;<font style="font-style: italic;">Amendment No. 1</font>&#8221;) amends and
                    supplements the statement on Schedule 13D filed on July 18, 2022 (the &#8220;<font style="font-style: italic;">Original Filing</font>&#8221;) by Muneer A. Satter with respect to the common
                    stock, par value $0.001 per share (the &#8220;<font style="font-style: italic;">Common Stock</font>&#8221;), of Annexon, Inc. (the &#8220;<font style="font-style: italic;">Company</font>&#8221;). The Original Filing remains in effect except to the extent that it is amended, restated or superseded by information contained in this Amendment No. 1. Capitalized terms used and
                    not defined in this Amendment No. 1 have the meanings set forth in the Original Filing, <font style="font-style: italic;">provided</font>, <font style="font-style: italic;">that</font> references to SMTP II made in the Original Filing shall be deemed to be references to Alerce Medical.</div>
                  <div>&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">
                  <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Item&#160;2.</div>
                </td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">
                  <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Identity and Background.</div>
                </td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">
                  <div>&#160;</div>
                  <div style="font-family: 'Times New Roman', serif;">Item 2 is hereby amended and restated in its entirety as follows:</div>
                  <div>&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">
                  <div style="font-family: 'Times New Roman', serif;">(a) Muneer A. Satter (the &#8220;<font style="font-style: italic;">Reporting Person</font>&#8221;).</div>
                </td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">&#160;</td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">
                  <div style="font-family: 'Times New Roman', serif;">(b) The address of the principal business office of the Reporting Person is c/o Alerce Investment Management, L.P, 676 N. Michigan Avenue, Suite 4000,
                    Chicago IL, 60611.</div>
                </td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">&#160;</td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">
                  <div style="font-family: 'Times New Roman', serif;">(c) The Reporting Person is Founder and Managing Partner of Satter Medical Technology Partners, L.P. (&#8220;<font style="font-style: italic;">SMTP</font>&#8221;) and Alerce Medical Technology Partners, L.P. (&#8220;<font style="font-style: italic;">Alerce Medical</font>&#8221;) (formerly
                    known as Satter Medical Technology Partners II, L.P.), and Chairman of Satter Investment Management LLC, a family office and private investment firm. The principal business of the Reporting Person is to make investments in both private
                    and public companies in the medical technology industry (broadly defined to include biotech, medical devices and healthcare services) on behalf of SMTP, Alerce Medical, and various trusts and other entities affiliated with the Reporting
                    Person.</div>
                </td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">&#160;</td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">
                  <div style="font-family: 'Times New Roman', serif;">(d)-(e) During the last five years, the Reporting Person has not been convicted in a criminal proceeding (excluding traffic violations or similar
                    misdemeanors). During the last five years, the Reporting Person has not been party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment,
                    decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.</div>
                </td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">&#160;</td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">
                  <div style="font-family: 'Times New Roman', serif;">(f) The Reporting Person is a citizen of the United States of America.</div>
                </td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">&#160;</td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">
                  <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Item&#160;3.</div>
                </td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">
                  <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Source and Amount of Funds.</div>
                </td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">
                  <div>&#160;</div>
                  <div style="font-family: 'Times New Roman', serif;">Item 3 is hereby amended by the addition of the following:</div>
                  <div>&#160;</div>
                  <div style="font-family: 'Times New Roman', serif;">On February 10, 2023, Alerce Medical purchased 2,647,058 shares of Common Stock on Nasdaq for $6.80 per share, in cash, for total consideration of
                    approximately $18 million. The Reporting Person acquired beneficial ownership of the shares of Common Stock acquired by Alerce Medical. The source of funds for the acquisition of shares in the offering was capital committed by the
                    partners of Alerce Medical.</div>
                </td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">&#160;</td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">
                  <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Item&#160;5.</div>
                </td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">
                  <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Interest in Securities of the Issuer.</div>
                </td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 91.63%; vertical-align: top;" colspan="2">
                  <div>&#160;</div>
                  <div style="font-family: 'Times New Roman', serif;">Item 5 is hereby amended and restated as follows:</div>
                  <div>&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 4.15%; vertical-align: top;">
                  <div style="font-family: 'Times New Roman', serif;">(a)</div>
                </td>
                <td style="width: 87.48%; vertical-align: top;">
                  <div style="font-family: 'Times New Roman', serif; font-style: italic;">Amount beneficially owned as of the date hereof:</div>
                  <div style="font-family: 'Times New Roman', serif; font-style: italic;"> <br>
                  </div>
                  <div style="font-family: 'Times New Roman', serif;">The Reporting Person beneficially owns an aggregate of 7,679,521 shares of Common Stock. The shares of Common Stock beneficially owned by the Reporting
                    Person include (a) 240,000 shares of Common Stock that are held by Muneer A. Satter Revocable Trust, for which the Reporting Person serves as trustee, and, in such capacity, has sole voting and dispositive power over all such shares;
                    (b) 567,240 shares of Common Stock that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power
                    over all such shares; (c) 1,147,738 shares of Common Stock that are held by SMTP, for which the Reporting Person has sole voting&#160;</div>
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                <div style="text-align: center; font-family: 'Times New Roman', serif;">SCHEDULE 13D</div>
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                        <div style="font-family: 'Times New Roman', serif;">CUSIP No. 03589W102</div>
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                        <div style="font-family: 'Times New Roman', serif;">&#160;&#160;</div>
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                        <div style="text-align: right; font-family: 'Times New Roman', serif;">Page 4 of 5<br>
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                <td style="width: 87.48%; vertical-align: top;" colspan="2">
                  <div style="font-family: 'Times New Roman', serif;">and dispositive power over all such shares, (d) 5,101,046 shares of Common Stock that are held by Alerce Medical,<font style="font-size: 12pt;">&#160;</font>for which the Reporting Person has sole voting and dispositive power over all such shares, (e)<font style="font-size: 12pt;">&#160;</font>613,497 shares of
                    Common Stock that may be obtained by exercising Common Warrants held by Alerce Medical, for which the Reporting Person has sole voting and dispositive power over all such shares, and (f) 10,000 shares of Common Stock underlying vested
                    stock options awarded to the Reporting Person in his individual capacity by the Company for his service as a Company director (in addition to 24,000 shares of Common Stock underlying unvested stock options awarded to the Reporting
                    Person by the Company on June 9, 2022, as reported by the Reporting Person in a Form 4 filed with the SEC on June 13, 2022, which shares are not included in the Reporting Person&#8217;s beneficial ownership of Common Stock as of the date
                    hereof).</div>
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                <td style="width: 8.3%; vertical-align: top;" rowspan="1">&#160;</td>
                <td style="width: 4.15%; vertical-align: top;" rowspan="1">&#160;</td>
                <td style="width: 87.48%; vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
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                <td style="width: 8.3%; vertical-align: top;">&#160;</td>
                <td style="width: 4.15%; vertical-align: top;">&#160;</td>
                <td style="width: 87.48%; vertical-align: top;" colspan="2">
                  <div style="font-family: 'Times New Roman', serif; font-style: italic;">Percent of class:</div>
                  <div style="font-family: 'Times New Roman', serif; font-style: italic;"> <br>
                  </div>
                  <div style="font-family: 'Times New Roman', serif;">In the aggregate, the Reporting Persons beneficially owns 7,679,521 shares of Common Stock, or 15.0% of the total number of shares of Common Stock
                    outstanding, as calculated<font style="font-size: 12pt;">&#160;</font>pursuant to Rule 13d-3(d)(1)(i).</div>
                  <div style="font-family: 'Times New Roman', serif;">All percentages calculated in this Schedule 13D are based upon 50,493,255 shares of Common Stock outstanding as of February 15, 2023, as disclosed to
                    the Reporting Person by the Company, adjusted, for the purposes of calculating the Reporting Person&#8217;s percentage beneficial ownership of the class of Common Stock, pursuant to Rule 13d-3(d)(1)(i).</div>
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                  <div style="font-family: 'Times New Roman', serif;">(b)</div>
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                  <div style="font-family: 'Times New Roman', serif;">Number of shares as to which such person has:</div>
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                  <div style="font-family: 'Times New Roman', serif;">(i)</div>
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                  <div style="font-family: 'Times New Roman', serif;">sole power to vote or to direct the vote: See Item&#160;7 on the cover pages hereto.</div>
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                <td style="width: 4.15%; vertical-align: top;">&#160;</td>
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                  <div style="font-family: 'Times New Roman', serif;">(ii)</div>
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                  <div style="font-family: 'Times New Roman', serif;">shared power to vote or to direct the vote: See Item&#160;8 on the cover pages hereto.</div>
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                <td style="width: 4.15%; vertical-align: top;">&#160;</td>
                <td style="width: 3.31%; vertical-align: top;">&#160;</td>
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                  <div style="font-family: 'Times New Roman', serif;">(iii)</div>
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                  <div style="font-family: 'Times New Roman', serif;">sole power to dispose or to direct the disposition of: See Item&#160;9 on the cover pages hereto.</div>
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                <td style="width: 4.15%; vertical-align: top;">&#160;</td>
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                  <div style="font-family: 'Times New Roman', serif;">(iv)</div>
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                  <div style="font-family: 'Times New Roman', serif;">shared power to dispose or to direct the disposition of: See Item&#160;10 on the cover pages hereto.</div>
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                  <div style="font-family: 'Times New Roman', serif;">(c)</div>
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                <td style="width: 87.48%; vertical-align: top;" colspan="2">
                  <div style="font-family: 'Times New Roman', serif;">The information set forth in Item 3 of this Schedule 13D is hereby incorporated by reference into this Item 5(c), as applicable.</div>
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                  <div style="font-family: 'Times New Roman', serif;">(d)</div>
                </td>
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                  <div style="font-family: 'Times New Roman', serif;">Information regarding the holders of the shares of Common Stock beneficially owned by the Reporting Person is disclosed in Item 5(a). Such holders and
                    their participating partners or beneficiaries, as the case may be, are ultimately entitled to the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities.</div>
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                  <div style="font-family: 'Times New Roman', serif;">(e)</div>
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                  <div style="font-family: 'Times New Roman', serif;">Not applicable</div>
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            <div style="text-align: center; font-family: 'Times New Roman', serif; font-weight: bold;">SIGNATURE</div>
            <div style="text-indent: 24.5pt; margin-top: 12pt; font-family: 'Times New Roman', serif;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and
              correct.</div>
            <div style="margin-top: 12pt; font-family: 'Times New Roman', serif;">
              <div style="margin-top: 12pt;">Date: February 17, 2023</div>
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                    <div style="font-family: 'Times New Roman', serif;">By:</div>
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                    <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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                  <td style="width: 37.18%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                    <div style="font-family: 'Times New Roman', serif;">/s/ Muneer A. Satter</div>
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                  <td style="width: 43.82%; vertical-align: top;">&#160;</td>
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                    <div style="font-family: 'Times New Roman', serif;">Muneer A. Satter</div>
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