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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Related Party [Member] | Pre-Funded Warrants [Member] | Pre-Funded Warrants and Common Warrants [Member] | Common Stock [Member] | Common Stock [Member] Related Party [Member] | Common Stock [Member] Pre-Funded Warrants [Member] | Common Stock [Member] Pre-Funded Warrants and Common Warrants [Member] | Additional Paid-in Capital [Member] | Additional Paid-in Capital [Member] Related Party [Member] | Additional Paid-in Capital [Member] Pre-Funded Warrants [Member] | Additional Paid-in Capital [Member] Pre-Funded Warrants and Common Warrants [Member] | Accumulated Other Comprehensive Loss [Member] | Accumulated Deficit [Member]
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning Balance, Values at Dec. 31, 2021 | $ 231,909 |  |  |  | $ 39 |  |  |  | $ 528,365 |  |  |  | $ (180) | $ (296,315)
Beginning Balance, Shares at Dec. 31, 2021 |  |  |  |  | 38,560,854 |  |  |  |  |  |  |  |  |
Stock-based compensation | 18,516 |  |  |  |  |  |  |  | 18,516 |  |  |  |  |
Stock option exercises | 80 |  |  |  |  |  |  |  | 80 |  |  |  |  |
Stock option exercises, Shares |  |  |  |  | 15,364 |  |  |  |  |  |  |  |  |
Issuance of common stock, pre-funded warrants and common warrants, net of issuance costs, Value |  |  |  | $ 122,488 |  |  |  | $ 9 |  |  |  | $ 122,479 |  |
Issuance of common stock, pre-funded warrants and common warrants, net of issuance cost, Shares |  |  |  |  |  |  |  | 9,013,834 |  |  |  |  |  |
Issuance of common stock per Employee Stock Purchase Plan purchase | 340 |  |  |  |  |  |  |  | 340 |  |  |  |  |
Issuance of common stock per Employee Stock Purchase Plan purchase, Shares |  |  |  |  | 121,126 |  |  |  |  |  |  |  |  |
Restricted stock vested in the period |  |  |  |  | 11,817 |  |  |  |  |  |  |  |  |
Other comprehensive gain (loss) | (192) |  |  |  |  |  |  |  |  |  |  |  | (192) |
Net loss | (141,947) |  |  |  |  |  |  |  |  |  |  |  |  | (141,947)
Ending Balance, Values at Dec. 31, 2022 | 231,194 |  |  |  | $ 48 |  |  |  | 669,780 |  |  |  | (372) | (438,262)
Ending Balance, Shares at Dec. 31, 2022 |  |  |  |  | 47,722,995 |  |  |  |  |  |  |  |  |
Stock-based compensation | 18,183 |  |  |  |  |  |  |  | 18,183 |  |  |  |  |
Stock option exercises | $ 145 |  |  |  |  |  |  |  | 145 |  |  |  |  |
Stock option exercises, Shares | 76,888 |  |  |  | 76,888 |  |  |  |  |  |  |  |  |
Exercise of pre-funded warrants, Value |  |  |  |  | $ 3 |  |  |  | (3) |  |  |  |  |
Exercise of pre-funded warrants, Shares |  |  |  |  | 2,582,557 |  |  |  |  |  |  |  |  |
Issuance of common stock, pre-funded warrants and common warrants, net of issuance costs, Value |  | $ 17,470 | $ 117,002 |  |  | $ 2 | $ 25 |  |  | $ 17,468 | $ 116,977 |  |  |
Issuance of common stock, pre-funded warrants and common warrants, net of issuance cost, Shares |  |  |  |  |  | 2,646,458 | 25,035,000 |  |  |  |  |  |  |
Issuance of common stock per Employee Stock Purchase Plan purchase | $ 479 |  |  |  |  |  |  |  | 479 |  |  |  |  |
Issuance of common stock per Employee Stock Purchase Plan purchase, Shares |  |  |  |  | 133,105 |  |  |  |  |  |  |  |  |
Restricted stock vested in the period |  |  |  |  | 172,096 |  |  |  |  |  |  |  |  |
Other comprehensive gain (loss) | 320 |  |  |  |  |  |  |  |  |  |  |  | 320 |
Net loss | (134,237) |  |  |  |  |  |  |  |  |  |  |  |  | (134,237)
Ending Balance, Values at Dec. 31, 2023 | $ 250,556 |  |  |  | $ 78 |  |  |  | $ 823,029 |  |  |  | $ (52) | $ (572,499)
Ending Balance, Shares at Dec. 31, 2023 |  |  |  |  | 78,369,099 |  |  |  |  |  |  |  |  |

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