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v3.24.1

Commitments and Contingencies - Additional Information (Detail) | 1 Months Ended | 12 Months Ended | 24 Months Ended
--- | --- | --- | ---
Nov. 30, 2021 | Mar. 31, 2019 USD ($) | Nov. 30, 2011 USD ($) | Dec. 31, 2023 USD ($) Claim | Dec. 31, 2022 USD ($) | Nov. 30, 2023 USD ($)
Gain Contingencies [Line Items] |  |  |  |  |  |
Sublease starting year and month | 2021-12 |  |  |  |  |
Sublease expiration year and month | 2023-11 |  |  |  |  |
Aggregate sublease payment receivable |  |  |  |  |  | $ 3,400,000
Sublease Income |  |  |  | $ 2,000,000 | $ 2,100,000 |
Operating lease right-of-use assets |  |  |  | 18,009,000 | 19,128,000 |
Lease liabilities |  |  |  | $ 31,355,000 |  |
Weighted average incremental borrowing rate |  |  |  | 8.40% |  |
Operating lease cost |  |  |  | $ 2,300,000 | 2,100,000 |
Variable lease payments |  |  |  | 1,500,000 | 1,000,000 |
Income (loss) |  |  |  | (134,237,000) | (141,947,000) |
Loss contingency accrual |  |  |  | $ 0 |  |
Indemnification Agreement [Member] |  |  |  |  |  |
Gain Contingencies [Line Items] |  |  |  |  |  |
Loss contingency pending claims | Claim |  |  |  | 0 |  |
Stanford Agreement [Member] | Research and Development Arrangement [Member] |  |  |  |  |  |
Gain Contingencies [Line Items] |  |  |  |  |  |
Sponsor research agreements, commitment amount |  |  | $ 500,000 |  |  |
Proceeds from funding |  |  |  | $ 600,000 |  |
Sponsored Research Agreement [Member] |  |  |  |  |  |
Gain Contingencies [Line Items] |  |  |  |  |  |
Maximum threshold period allowed for filing market authorization |  | 15 years |  |  |  |
Income (loss) |  |  |  | $ 0 | $ 0 |
Sponsored Research Agreement [Member] | Research and Development Arrangement [Member] |  |  |  |  |  |
Gain Contingencies [Line Items] |  |  |  |  |  |
Maximum expected research funding |  | $ 700,000 |  |  |  |
Brisbane, California [Member] |  |  |  |  |  |
Gain Contingencies [Line Items] |  |  |  |  |  |
Operating lease, term of contract |  |  |  | 10 years |  |
Operating lease, expiration month and year |  |  |  | 2031-10 |  |
Operating lease, renewal term |  |  |  | 10 years |  |
Operating lease right-of-use assets |  |  |  | $ 18,000,000 |  |
Lease liabilities |  |  |  | $ 31,400,000 |  |
Weighted average remaining lease term |  |  |  | 7 years 9 months 18 days |  |

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