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Commitments and Contingencies - Additional Information (Detail)
 1 Months Ended 12 Months Ended 24 Months Ended
Nov. 30, 2021
Mar. 31, 2019
USD ($)
Nov. 30, 2011
USD ($)
Dec. 31, 2023
USD ($)
Claim
Dec. 31, 2022
USD ($)
Nov. 30, 2023
USD ($)
Gain Contingencies [Line Items]            
Sublease starting year and month 2021-12          
Sublease expiration year and month 2023-11          
Aggregate sublease payment receivable           $ 3,400,000
Sublease Income       $ 2,000,000 $ 2,100,000  
Operating lease right-of-use assets       18,009,000 19,128,000  
Lease liabilities       $ 31,355,000    
Weighted average incremental borrowing rate       8.40%    
Operating lease cost       $ 2,300,000 2,100,000  
Variable lease payments       1,500,000 1,000,000  
Income (loss)       (134,237,000) (141,947,000)  
Loss contingency accrual       $ 0    
Indemnification Agreement [Member]            
Gain Contingencies [Line Items]            
Loss contingency pending claims | Claim       0    
Stanford Agreement [Member] | Research and Development Arrangement [Member]            
Gain Contingencies [Line Items]            
Sponsor research agreements, commitment amount     $ 500,000      
Proceeds from funding       $ 600,000    
Sponsored Research Agreement [Member]            
Gain Contingencies [Line Items]            
Maximum threshold period allowed for filing market authorization   15 years        
Income (loss)       $ 0 $ 0  
Sponsored Research Agreement [Member] | Research and Development Arrangement [Member]            
Gain Contingencies [Line Items]            
Maximum expected research funding   $ 700,000        
Brisbane, California [Member]            
Gain Contingencies [Line Items]            
Operating lease, term of contract       10 years    
Operating lease, expiration month and year       2031-10    
Operating lease, renewal term       10 years    
Operating lease right-of-use assets       $ 18,000,000    
Lease liabilities       $ 31,400,000    
Weighted average remaining lease term       7 years 9 months 18 days