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Equity Incentive Plan (Tables)

12 Months Ended

Dec. 31, 2024

Share-Based Payment Arrangement [Abstract]

Summary of Stock Option Activity

The following table presents stock option activity under the Plans for the period:

		Number of Shares				Weighted- Average Exercise Price Per Share				Weighted- Average Remaining Contractual Term (in years)				Aggregate Intrinsic Value (in thousands)
Balances as of December 31, 2023			9,208,970			$	10.31				7.53			$	2,930
Stock options granted			6,749,824			$	5.73
Stock options exercised			(382,122	)		$	3.22
Stock options forfeited			(981,952	)		$	11.55
Balances as of December 31, 2024			14,594,720			$	8.29				7.94			$	4,059
Vested and Exercisable as of December 31, 2024			6,813,637			$	11.06				6.58			$	2,194

Summary of RSU Activity under Equity Incentive Plan

A summary of RSU activity under the equity incentive plan and related information is as follows:

		Number of Shares				Weighted-Average Grant Date Fair Value Per Share
Unvested as of December 31, 2023			495,579			$	5.69
Granted			602,600				5.13
Vested			(197,177	)			5.85
Cancelled			(130,974	)			5.29
Unvested as of December 31, 2024			770,028			$	5.28

Summary of Stock-Based Compensation Expense

The total stock-based compensation expense recognized was as follows (in thousands):

		Year Ended December 31,
		2024				2023
Research and development		$	9,670			$	8,878
General and administrative			9,763				9,305
Total stock-based compensation expense		$	19,433			$	18,183

Summary of Fair Value of Each Stock Option Issued Estimated on the Date of Grant Using the Black-Scholes Option Pricing Model

The fair value of each stock option issued was estimated on the date of grant using the Black-Scholes option pricing model with the following assumptions:

		Year Ended December 31,
		2024		2023
Expected term (in years)		5.50 - 6.08		5.50 - 6.08
Expected volatility		95.90% - 99.80%		81.20% - 82.40%
Risk-free interest rate		3.48% - 4.65%		3.47% - 4.85%
Dividend yield		—		—

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Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit.

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Tabular disclosure of the changes in outstanding nonvested restricted stock units.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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