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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Operating activities:    
Net loss $ (138,200) $ (134,237)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 2,150 2,148
Accretion of discount on available-for-sale securities (9,054) (2,550)
Stock-based compensation 19,433 18,183
Reduction in the carrying amount of right-of-use assets 1,304 1,119
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (300) 1,352
Other non-current assets (3,184)  
Accounts payable 4,936 (2,077)
Accrued and other current liabilities 7,292 (3,577)
Operating lease liabilities (2,383) (1,503)
Net cash used in operating activities (118,006) (121,142)
Investing activities:    
Purchases of property and equipment (15) (193)
Purchases of available-for-sale securities (583,932) (108,088)
Proceeds from maturities of available-for-sale securities 365,150 178,984
Net cash (used in) provided by investing activities (218,797) 70,703
Financing activities:    
Proceeds from the exercise of common stock options 1,232 90
Proceeds from Employee Stock Purchase Plan purchases 362 479
Proceeds from the issuance of common stock, including to related parties, of zero and $17,995 for the years ended December 31, 2024 and 2023, respectively 44,371 17,995
Proceeds from the issuance of common stock and pre-funded warrants, net of commissions 117,500 117,515
Payment of financing costs (2,259) (555)
Net cash provided by financing activities 161,206 135,524
(Decrease) increase in cash, cash equivalents and restricted cash (175,597) 85,085
Effect of exchange rate changes on cash, cash equivalents and restricted cash (15) 5
Cash, cash equivalents and restricted cash    
Beginning of period 226,142 141,052
End of period 50,530 226,142
Supplemental disclosure of cash flow information:    
Cash paid for amounts included in the measurement of lease liability 4,893 4,728
Non-cash investing and financing activities:    
Deferred offering costs included in accounts payable and accrued liabilities 3 $ 483
Deferred offering costs included in other non-current assets $ 51