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Equity Incentive Plans (Tables)

6 Months Ended

Jun. 30, 2025

Share-Based Payment Arrangement [Abstract]

Summary of Stock Option Activity

The following table presents stock option activity under the Plans for the period:

		Number of Shares				Weighted- Average Exercise Price Per Share				Weighted- Average Remaining Contractual Term (in years)				Aggregate Intrinsic Value (in thousands)
Balances as of December 31, 2024			14,594,720			$	8.29				7.94			$	4
Stock options granted			6,159,513			$	2.55
Stock options exercised			(43,113	)		$	1.44
Stock options forfeited			(690,940	)		$	6.52
Balances as of June 30, 2025			20,020,180			$	6.60				8.08			$	286
Vested and Exercisable as of June 30, 2025			8,373,556			$	9.99				6.50			$	42

Summary of RSU Activity under Equity Incentive Plan

A summary of RSU activity under the Company’s equity incentive plan and related information is as follows:

		Number of Shares				Weighted-Average Grant Date Fair Value Per Share
Unvested as of December 31, 2024			770,028			$	5.28
Granted			1,072,921				2.50
Vested			(289,735	)			5.62
Cancelled			(100,215	)			3.11
Unvested as of June 30, 2025			1,452,999			$	3.31

Summary of Stock-Based Compensation Expense

The total stock-based compensation expense recognized was as follows (in thousands):

		Three Months Ended June 30,								Six Months Ended June 30,
		2025				2024				2025				2024
Research and development		$	2,688			$	2,311			$	5,517			$	4,593
General and administrative			1,517				2,631				3,766				5,009
Total stock-based compensation expense		$	4,205			$	4,942			$	9,283			$	9,602

Summary of Fair Value of Each Stock Option Issued Estimated on the Date of Grant Using the Black-Scholes Option Pricing Model

The fair value of each stock option issued was estimated on the date of grant using the Black-Scholes option pricing model with the following assumptions:

		Three Months Ended June 30,				Six Months Ended June 30,
		2025		2024		2025		2024
Expected term (in years)		5.50 - 6.08		6.08		5.50 - 6.08		6.02 - 6.08
Expected volatility		93.70% - 93.80%		96.20% - 97.80%		92.30% - 93.80%		95.90% - 97.80%
Risk-free interest rate		4.03% - 4.15%		4.22% - 4.65%		4.03% - 4.49%		4.22% - 4.65%
Dividend yield		—		—		—		—

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Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit.

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Tabular disclosure of the changes in outstanding nonvested restricted stock units.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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