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Equity Incentive Plans (Tables)

9 Months Ended

Sep. 30, 2025

Share-Based Payment Arrangement [Abstract]

Summary of Stock Option Activity

The following table presents stock option activity under the Plans for the period:

		Number of Shares				Weighted- Average Exercise Price Per Share				Weighted- Average Remaining Contractual Term (in years)				Aggregate Intrinsic Value (in thousands)
Balances as of December 31, 2024			14,594,720			$	8.29				7.94			$	4,059
Stock options granted			6,219,513			$	2.55
Stock options exercised			(44,402	)		$	1.47
Stock options forfeited			(1,388,077	)		$	5.79
Balances as of September 30, 2025			19,381,754			$	6.64				7.72			$	3,356
Vested and Exercisable as of September 30, 2025			9,350,620			$	9.50				6.34			$	538

Summary of RSU Activity under Equity Incentive Plan

A summary of RSU activity under the Company’s equity incentive plan and related information is as follows:

		Number of Shares				Weighted-Average Grant Date Fair Value Per Share
Unvested as of December 31, 2024			770,028			$	5.28
Granted			1,072,921				2.50
Vested			(342,922	)			5.35
Cancelled			(191,085	)			3.08
Unvested as of September 30, 2025			1,308,942			$	3.30

Summary of Stock-Based Compensation Expense

The total stock-based compensation expense recognized was as follows (in thousands):

		Three Months Ended September 30,								Nine Months Ended September 30,
		2025				2024				2025				2024
Research and development		$	2,380			$	2,325			$	7,897			$	6,918
General and administrative			1,455				2,284				5,221				7,293
Total stock-based compensation expense		$	3,835			$	4,609			$	13,118			$	14,211

Summary of Fair Value of Each Stock Option Issued Estimated on the Date of Grant Using the Black-Scholes Option Pricing Model

The fair value of each stock option issued was estimated on the date of grant using the Black-Scholes option pricing model with the following assumptions:

		Three Months Ended September 30,				Nine Months Ended September 30,
		2025		2024		2025		2024
Expected term (in years)		6.08		6.02 - 6.08		5.50 - 6.08		6.02 - 6.08
Expected volatility		93.30%		96.80% - 97.60%		92.30% - 93.80%		95.90% - 97.80%
Risk-free interest rate		3.95%		3.48% - 4.15%		3.95% - 4.49%		3.48% - 4.65%
Dividend yield		—		—		—		—

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Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit.

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Tabular disclosure of the changes in outstanding nonvested restricted stock units.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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