<SEC-DOCUMENT>0000895345-25-000365.txt : 20251121
<SEC-HEADER>0000895345-25-000365.hdr.sgml : 20251121
<ACCEPTANCE-DATETIME>20251121192718
ACCESSION NUMBER:		0000895345-25-000365
CONFORMED SUBMISSION TYPE:	SCHEDULE 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251121
DATE AS OF CHANGE:		20251121

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Annexon, Inc.
		CENTRAL INDEX KEY:			0001528115
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				275414423
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91583
		FILM NUMBER:		251509344

	BUSINESS ADDRESS:	
		STREET 1:		1400 SIERRA POINT PARKWAY
		STREET 2:		BLDG C, SUITE 200
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005
		BUSINESS PHONE:		(650) 822-5500

	MAIL ADDRESS:	
		STREET 1:		1400 SIERRA POINT PARKWAY
		STREET 2:		BLDG C, SUITE 200
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Satter Muneer A
		CENTRAL INDEX KEY:			0001315797
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13D/A

	MAIL ADDRESS:	
		STREET 1:		C/O SATTER INVESTMENT MANAGEMENT, LLC
		STREET 2:		676 NORTH MICHIGAN AVENUE, SUITE 4000
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60611
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13D" xmlns:com="http://www.sec.gov/edgar/common">
<headerData>
<submissionType>SCHEDULE 13D/A</submissionType>
<previousAccessionNumber>0000895345-22-000552</previousAccessionNumber>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001315797</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>



</filerInfo>
</headerData>
<formData>
<coverPageHeader>
<amendmentNo>2</amendmentNo>
<securitiesClassTitle>Common Stock, par value $0.001</securitiesClassTitle>
<dateOfEvent>11/19/2025</dateOfEvent>
<previouslyFiledFlag>true</previouslyFiledFlag>
<issuerInfo>
<issuerCIK>0001528115</issuerCIK>
<issuerCUSIP>03589W102</issuerCUSIP>
<issuerName>Annexon, Inc.</issuerName>
<address>
<com:street1>c/o Alerce Investment Management, L.P.</com:street1>
<com:street2>676 N. Michigan Avenue, Suite 4000</com:street2>
<com:city>Chicago</com:city>
<com:stateOrCountry>IL</com:stateOrCountry>
<com:zipCode>60611</com:zipCode>
</address>
</issuerInfo>
<authorizedPersons>
<notificationInfo>
<personName>Muneer A. Satter</personName>
<personPhoneNum>312-448-5500</personPhoneNum>
<personAddress>
<com:street1>c/o Alerce Investment Management, L.P.</com:street1>
<com:street2>676 N. Michigan Avenue, Suite 4000</com:street2>
<com:city>Chicago</com:city>
<com:stateOrCountry>IL</com:stateOrCountry>
<com:zipCode>60611</com:zipCode>
</personAddress>
</notificationInfo>
</authorizedPersons>
</coverPageHeader>
<reportingPersons>
<reportingPersonInfo>
<reportingPersonCIK>0001315797</reportingPersonCIK>
<reportingPersonName>Satter Muneer A</reportingPersonName>
<fundType>OO</fundType>
<citizenshipOrOrganization>X1</citizenshipOrOrganization>
<soleVotingPower>10444134</soleVotingPower>
<sharedVotingPower>0</sharedVotingPower>
<soleDispositivePower>10444134</soleDispositivePower>
<sharedDispositivePower>0</sharedDispositivePower>
<aggregateAmountOwned>10444134</aggregateAmountOwned>
<isAggregateExcludeShares>N</isAggregateExcludeShares>
<percentOfClass>7.2</percentOfClass>
<typeOfReportingPerson>IN</typeOfReportingPerson>
</reportingPersonInfo>
</reportingPersons>
<items1To7>
<item1>
<securityTitle>Common Stock, par value $0.001</securityTitle>
<issuerName>Annexon, Inc.</issuerName>
<issuerPrincipalAddress>
<com:street1>c/o Alerce Investment Management, L.P.</com:street1>
<com:street2>676 N. Michigan Avenue, Suite 4000</com:street2>
<com:city>Chicago</com:city>
<com:stateOrCountry>IL</com:stateOrCountry>
<com:zipCode>60611</com:zipCode>
</issuerPrincipalAddress>
<commentText>This Amendment No. 2 ("Amendment No. 2") amends and supplements the statement on Schedule 13D filed on July 18, 2022 (the "Original Filing") by Muneer A. Satter with respect to the common stock, par value $0.001 per share (the "Common Stock"), of Annexon, Inc. (the "Company"), as previously amended by Amendment No. 1 on February 17, 2023. The Original Filing as previously amended remains in effect except to the extent that it is amended, restated or superseded by information contained in this Amendment No. 2. Capitalized terms used and not defined in this Amendment No. 2 have the meanings set forth in the Original Filing as previously amended.</commentText>
</item1>
<item3>
<fundsSource>Item 3 is hereby amended by the addition of the following:&#13;
&#13;
From November 17th through 21st, 2025, Alerce Medical purchased 2,322,613 shares of Common Stock on Nasdaq for an average price (excluding commissions) of $3.73 per share, in cash, for total consideration of approximately $8.7 million, as further detailed in Item 5(c). The source of funds for the acquisition of shares in the offering was working capital of Alerce Medical drawn from capital committed by some or all of its limited partners.</fundsSource>
</item3>
<item5>
<percentageOfClassSecurities>Item 5(a) is amended and restated as follows:&#13;
&#13;
See Items 11 and 13 of the cover pages.&#13;
&#13;
The aggregate percentage of Common Stock beneficially owned by Mr. Satter is based upon 145,261,154 shares outstanding, including 144,545,657 shares outstanding as disclosed by the Issuer on November 13, 2025 in a Prospectus Supplement filed with the SEC pursuant to Rule 424(b)(5), 613,497 shares of Common Stock that may be acquired upon the exercise of Common Warrants held by Alerce Medical, and 102,000 shares of Common Stock that may be acquired within 60 days of the date hereof pursuant to the exercise of stock options held by Mr. Satter.</percentageOfClassSecurities>
<numberOfShares>Item 5(b) is amended and restated as follows:&#13;
&#13;
See Items 7, 8, 9 and 10 of the cover pages.</numberOfShares>
<transactionDesc>Item 5(c) is amended by the addition of the following tabular presentation of daily purchases of shares of Common Stock made for cash on the Nasdaq; in each case the daily average price is reported.&#13;
&#13;
November 17, 2025: 500,000 shares $2.99&#13;
November 18, 2025: 500,000 shares $3.18&#13;
November 19, 2025: 500,000 shares $3.94&#13;
November 20, 2025: 400,000 shares $4.48&#13;
November 21, 2025: 422,613 shares $4.28</transactionDesc>
</item5>
</items1To7>
<signatureInfo>
<signaturePerson>
<signatureReportingPerson>Satter Muneer A</signatureReportingPerson>
<signatureDetails>
<signature>/s/ Muneer Satter</signature>
<title>Satter Muneer A</title>
<date>11/21/2025</date>
</signatureDetails>
</signaturePerson>
</signatureInfo>
</formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
