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Outstanding Warrants (Details Narrative)
 1 Months Ended 12 Months Ended
Nov. 04, 2021
shares
Sep. 28, 2021
USD ($)
$ / shares
shares
Sep. 28, 2021
USD ($)
$ / shares
shares
Jun. 30, 2018
integer
$ / shares
Dec. 31, 2017
USD ($)
integer
$ / shares
shares
Mar. 31, 2017
USD ($)
integer
$ / shares
shares
Dec. 30, 2021
shares
Dec. 31, 2021
$ / shares
shares
Dec. 31, 2020
$ / shares
shares
Dec. 31, 2019
$ / shares
shares
Exercise price of warrants               $ 9.59 $ 37.50 $ 36.00
Stock Issued During Period, Shares, New Issues | shares 2,802           7,719      
Preferred Stock, Par or Stated Value Per Share               $ 0.00001 $ 0.00001  
Class of Warrant or Right, Outstanding | shares               227,719 50,417 260,727
Series B Preferred Stock [Member]                    
Preferred Stock, Par or Stated Value Per Share   $ 1,000 $ 1,000              
Stock Repurchased During Period, Value | $   $ 3,300,000                
Series B Preferred Stock [Member] | Maximum [Member]                    
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right | shares   192,982 192,982              
Series B Preferred Stock [Member] | Securities Purchase Agreement [Member]                    
Exercise price of warrants   $ 9.45 $ 9.45              
Stock Issued During Period, Shares, New Issues | shares   3,300                
Preferred Stock, Par or Stated Value Per Share   $ 1,000 $ 1,000              
Stock Repurchased During Period, Value | $   $ 3,300,000                
Purchase price of warrants | $     $ 3,000,000              
Series B Preferred Stock [Member] | Securities Purchase Agreement [Member] | Maximum [Member]                    
Warrants to purchase common stock | shares   192,982 192,982              
Banker Warrant [Member]                    
Exercise price of warrants         $ 52.50          
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right | shares         3,333          
Q1 2017 Warrants [Member]                    
Exercise price of warrants           $ 24.00        
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right | shares           3,125        
Warrants to purchase common stock | shares           111,875        
Proceeds from Issuance of Warrants | $           $ 2,685,000        
Conversion of Stock, Description           Each unit consisted of one hundred and fifty shares of the Company’s common stock and one hundred and fifty warrants for the purchase of one share of the Company’s common stock (“Q1 2017 Warrants”)        
Shares Issued, Price Per Share           $ 63.00        
Debt Instrument, Convertible, Threshold Consecutive Trading Days | integer           5        
Redeem warrant shares at a price           $ 1.50        
Warrant description           These warrants expired unexercised in March 2020        
Q1 2017 Warrants [Member] | Customary Adjustment [Member]                    
Exercise price of warrants           $ 39.00        
Q4 2017 Warrants [Member]                    
Exercise price of warrants         $ 18.00          
Warrants to purchase common stock | shares         98,227          
Proceeds from Issuance of Warrants | $         $ 1,768,080          
Conversion of Stock, Description         Each unit consisted of one hundred and fifty shares of the Company’s common stock and one hundred and fifty warrants for the purchase of one share of the Company’s common stock (“Q4 2017 Warrants”)          
Shares Issued, Price Per Share         $ 54.00          
Debt Instrument, Convertible, Threshold Consecutive Trading Days | integer         5          
Redeem warrant shares at a price         $ 1.50          
Warrant description       These warrants expired unexercised in June 2021 These warrants expired unexercised in December 2020          
Q4 2017 Warrants [Member] | Customary Adjustments [Member]                    
Exercise price of warrants         $ 30.00          
Q2 2018 Warrants [Member]                    
Exercise price of warrants       $ 37.5            
Conversion of Stock, Description       each unit consisting of one share of the Company’s common stock and one Q2 2018 Warrant            
Shares Issued, Price Per Share       $ 60.00            
Debt Instrument, Convertible, Threshold Consecutive Trading Days | integer       5            
Redeem warrant shares at a price       $ 1.50            
Warrant description       The Q2 2018 Warrants are exercisable commencing July 1, 2018 until June 30, 2021            
Placement Agent Warrants [Member] | Private Placement [Member]                    
Exercise price of warrants   $ 10.40 $ 10.40              
Class of Warrant or Right, Outstanding | shares   34,737 34,737