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Income taxes - Reconciliation to Federal Statutory Rate (Details) - USD ($)
3 Months Ended 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Amount [Abstract]          
Tax at federal statutory rate     $ (13,011,000) $ (4,005,000) $ (22,612,000)
Change in valuation allowance     16,767,000 4,717,000 42,772,000
Impact of foreign operations     5,010,000 (3,949,000) 3,285,000
Stock-based compensation     696,000 1,731,000 10,974,000
State taxes, net of federal benefits     (682,000) 1,872,000 (2,997,000)
Tax credits     (3,538,000) (5,123,000) (5,996,000)
Income tax (benefit) expense $ 100,000 $ (3,900,000) 4,826,000 (4,428,000) 1,359,000
Impact of IRS audit     0 0 (9,687,000)
Other     (539,000) 24,000 528,000
Permanent tax adjustments     123,000 305,000 3,786,000
Restructuring adjustments $ 3,500,000   $ 0 $ 0 $ (18,694,000)
Percent [Abstract]          
Tax at federal statutory rate     21.00% 21.00% 21.00%
Change in valuation allowance     (27.10%) (24.70%) (39.70%)
Impact of foreign operations     (8.10%) 20.70% (3.10%)
Stock-based compensation     (1.10%) (9.10%) (10.20%)
State taxes, net of federal benefits     1.10% (9.80%) 2.80%
Tax credits     (5.70%) (26.80%) (5.60%)
Income tax provision at effective rate 0.30% (4.30%) (7.80%) 23.20% (1.30%)
Impact of IRS audit     0.00% 0.00% 9.00%
Other     0.90% (0.10%) (0.60%)
Permanent Tax adjustment     (0.20%) (1.60%) (3.50%)
Restructuring adjustments     0.00% 0.00% 17.40%