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v3.23.2

LICENSE AGREEMENTS (Details) |  | 1 Months Ended | 3 Months Ended | 6 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Apr. 28, 2021 USD ($) | Mar. 31, 2022 USD ($) | Jun. 30, 2023 USD ($) | Mar. 31, 2023 USD ($) | Mar. 31, 2022 USD ($) | Jun. 30, 2023 USD ($) | Jun. 30, 2023 EUR (€) | Jun. 30, 2022 USD ($) | Dec. 31, 2022 USD ($) | Jan. 24, 2022 USD ($)
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Milestone payment received |  |  |  |  |  | $ 5,095,837 |  | $ 30,000,000 |  |
Revenue |  |  | $ 3,917,467 |  |  | 6,904,163 |  |  |  |
Deferred revenue, current |  |  | 29,312,439 |  |  | 29,312,439 |  |  | $ 17,980,599 |
Deferred revenue, net of current |  |  | 3,231,929 |  |  | 3,231,929 |  |  | $ 9,467,932 |
Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  |  |  |  |  |  |  |  | $ 705,000,000.0
Upfront Payment |  |  |  |  | $ 30,000,000.0 |  |  |  |  |
Deferred revenue liability |  | $ 30,000,000.0 | 20,500,000 |  | 30,000,000.0 | 20,500,000 |  |  |  |
Revenue |  |  | 3,900,000 |  |  | 6,900,000 |  |  |  |
Deferred revenue, current |  |  | 17,300,000 |  |  | 17,300,000 |  |  |  |
Deferred revenue, net of current |  |  | $ 3,200,000 |  |  | $ 3,200,000 |  |  |  |
Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2023-07-01 |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Revenue, Remaining Performance Obligation, Percentage |  |  | 84.00% |  |  | 84.00% |  |  |  |
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period |  |  | 6 months |  |  | 6 months |  |  |  |
Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2024-07-01 |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Revenue, Remaining Performance Obligation, Percentage |  |  | 84.00% |  |  | 84.00% |  |  |  |
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period |  |  | 12 months |  |  | 12 months |  |  |  |
Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, Japan |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  |  | $ 89,000,000 |  |  |  |  |  |
Upfront Payment |  |  |  | 12,000,000.0 |  |  |  |  |  |
Milestone payment received |  |  |  | $ 12,000,000.0 |  |  |  |  |  |
Deferred revenue liability |  |  | $ 12,000,000.0 |  |  | $ 12,000,000.0 |  |  |  |
Deferred revenue, current |  |  | 12,000,000.0 |  |  | $ 12,000,000.0 |  |  |  |
Rome License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Notice period |  |  |  |  |  | 90 days | 90 days |  |  |
JHU License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Notice period |  |  |  |  |  | 60 days | 60 days |  |  |
Milestone payments to be made upon completion of certain phases |  | 500,000 |  |  | $ 500,000 |  |  |  |  |
Threshold period to cure breach |  |  |  |  |  | 30 days | 30 days |  |  |
CSMC License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Notice period |  |  |  |  |  | 90 days | 90 days |  |  |
Exosomes License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Notice period | 90 days |  |  |  |  | 90 days | 90 days |  |  |
Upfront Payment | $ 10,000 |  |  |  |  |  |  |  |  |
Minimum | Rome License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Minimum annual royalty payments | € |  |  |  |  |  |  | € 20,000 |  |  |
Maximum | JHU License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  | $ 1,850,000 |  |  | $ 1,850,000 |  |  |  |
Completion Of Phase Two Due | JHU License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Milestones paid |  | $ 250,000 |  |  |  |  |  |  |  |
Patent rights | JHU License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Agreement effective period |  |  |  |  |  | 20 years | 20 years |  |  |
Patent rights | Exosomes License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Agreement effective period | 20 years |  |  |  |  |  |  |  |  |
Particular Patent or Application or Any Particular Licensed Product | Exosomes License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Notice period | 60 days |  |  |  |  |  |  |  |  |
Non Payment of Royalties | CSMC License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Agreement termination period |  |  |  |  |  | 30 days | 30 days |  |  |
Non Payment of Royalties | Exosomes License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Threshold period to cure breach |  |  |  |  |  | 30 days | 30 days |  |  |
CSMC Agreement Compliance | CSMC License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Agreement termination period |  |  |  |  |  | 90 days | 90 days |  |  |
CSMC Agreement Compliance | Exosomes License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Threshold period to cure breach |  |  |  |  |  | 90 days | 90 days |  |  |
Material Breach Has Not Been Cured | CSMC License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Agreement termination period |  |  |  |  |  | 90 days | 90 days |  |  |
Material Breach Has Not Been Cured | Exosomes License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Threshold period to cure breach |  |  |  |  |  | 90 days | 90 days |  |  |
Fails To Cure Breach after Notice From CSMC | CSMC License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Agreement termination period |  |  |  |  |  | 90 days | 90 days |  |  |
Fails To Cure Breach after Notice From CSMC | Exosomes License Agreement |  |  |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |  |  |
Threshold period to cure breach | 60 days |  |  |  |  | 90 days | 90 days |  |  |

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