XML 52 R35.htm IDEA: XBRL DOCUMENT v3.24.0.1
LICENSE AND DISTRIBUTION AGREEMENTS (Details)
1 Months Ended 3 Months Ended 12 Months Ended
Mar. 31, 2022
USD ($)
Jan. 31, 2022
USD ($)
Mar. 31, 2023
USD ($)
Mar. 31, 2022
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2023
EUR (€)
Dec. 31, 2022
USD ($)
Jan. 24, 2022
USD ($)
LICENSE AGREEMENTS                
Milestone payments to be made upon completion of certain phases         $ 10,000,000.0      
Revenue         25,178,066   $ 2,551,469  
Deferred revenue, current         24,270,465   17,980,599  
Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States                
LICENSE AGREEMENTS                
Potential milestone payments         90,000,000.0      
Milestone payments to be made upon completion of certain phases         10,000,000.0      
Upfront payment   $ 30,000,000.0   $ 30,000,000.0        
Deferred revenue liability $ 40,000,000.0     40,000,000.0 12,300,000      
Revenue         25,200,000   $ 2,600,000  
Deferred revenue, current         $ 12,300,000      
Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2024-07-01                
LICENSE AGREEMENTS                
Revenue, remaining performance obligation, expected timing of satisfaction, period         12 months      
Revenue, Remaining Performance Obligation, Percentage         100.00%      
Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, Japan                
LICENSE AGREEMENTS                
Potential milestone payments     $ 89,000,000.0          
Upfront payment     $ 12,000,000.0          
Deferred revenue liability         $ 12,000,000.0      
Deferred revenue, current         12,000,000.0      
CSMC | Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States                
LICENSE AGREEMENTS                
Deferred revenue liability         $ 40,000,000.0      
Rome License Agreement                
LICENSE AGREEMENTS                
Notice period         90 days 90 days    
JHU License Agreement                
LICENSE AGREEMENTS                
Notice period         60 days 60 days    
Threshold period to cure breach         30 days 30 days    
CSMC License Agreement                
LICENSE AGREEMENTS                
Notice period         90 days 90 days    
Exosomes License Agreement                
LICENSE AGREEMENTS                
Notice period         90 days 90 days    
Minimum | Rome License Agreement                
LICENSE AGREEMENTS                
Minimum annual royalty payments | €           € 20,000    
Maximum | Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States                
LICENSE AGREEMENTS                
Potential milestone payments               $ 605,000,000.0
Maximum | JHU License Agreement                
LICENSE AGREEMENTS                
Potential milestone payments         $ 1,850,000      
Completion Of Phase Two Due | JHU License Agreement                
LICENSE AGREEMENTS                
Milestones paid 250,000              
Milestone payments to be made upon completion of certain phases $ 500,000     $ 500,000        
Patent rights | JHU License Agreement                
LICENSE AGREEMENTS                
Agreement effective period         20 years 20 years    
Non Payment of Royalties | CSMC License Agreement                
LICENSE AGREEMENTS                
Agreement termination period         30 days 30 days    
Non Payment of Royalties | Exosomes License Agreement                
LICENSE AGREEMENTS                
Threshold period to cure breach         30 days 30 days    
CSMC Agreement Compliance | CSMC License Agreement                
LICENSE AGREEMENTS                
Agreement termination period         90 days 90 days    
CSMC Agreement Compliance | Exosomes License Agreement                
LICENSE AGREEMENTS                
Threshold period to cure breach         90 days 90 days    
Material Breach Has Not Been Cured | CSMC License Agreement                
LICENSE AGREEMENTS                
Agreement termination period         90 days 90 days    
Material Breach Has Not Been Cured | Exosomes License Agreement                
LICENSE AGREEMENTS                
Threshold period to cure breach         90 days 90 days    
Fails To Cure Breach after Notice From CSMC | CSMC License Agreement                
LICENSE AGREEMENTS                
Agreement termination period         90 days 90 days    
Fails To Cure Breach after Notice From CSMC | Exosomes License Agreement                
LICENSE AGREEMENTS                
Threshold period to cure breach         90 days 90 days    
Overdue payment obligation | CSMC License Agreement | CSMC                
LICENSE AGREEMENTS                
Revenue         $ 10,000,000.0      
Milestone payments, percentage claimed by CSMS         10.00%