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v3.25.1

LICENSE AND DISTRIBUTION AGREEMENTS (Details) |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Sep. 16, 2024 USD ($) | Dec. 31, 2024 USD ($) | Mar. 31, 2023 USD ($) | Dec. 31, 2024 USD ($) | Dec. 31, 2024 EUR (€) | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($) | Jan. 24, 2022 USD ($)
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Revenue |  |  |  | $ 22,270,465 |  | $ 25,178,066 |  |
Deferred revenue, current |  | $ 12,000,000 |  | 12,000,000 |  | 24,270,465 |  |
Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Potential milestone payments |  | 80,000,000 |  | 80,000,000 |  |  |  |
Milestone payments to be made upon completion of certain phases |  | 10,000,000 |  | 10,000,000 |  | 10,000,000 |  |
Upfront payment |  |  |  |  |  |  | $ 30,000,000 |
Revenue |  |  |  | 22,300,000 |  | 25,200,000 |  |
Deferred revenue, current |  |  |  |  |  | $ 12,300,000 |  |
Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, Japan |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Potential milestone payments |  |  | $ 89,000,000 |  |  |  |  |
Upfront payment |  |  | $ 12,000,000 |  |  |  |  |
Deferred revenue liability |  | 12,000,000 |  | 12,000,000 |  |  |  |
Deferred revenue, current |  | 12,000,000 |  | $ 12,000,000 |  |  |  |
Binding Term Sheet With Nippon Shinyaku Co Limited Europe |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Upfront payment | $ 20,000,000 |  |  |  |  |  |  |
Potential additional development and sales-based milestone payments | $ 715,000,000 |  |  |  |  |  |  |
Rome License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Notice period |  |  |  | 90 days | 90 days |  |  |
JHU License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Notice period |  |  |  | 60 days | 60 days |  |  |
Threshold period to cure breach |  |  |  | 30 days | 30 days |  |  |
CSMC License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Notice period |  |  |  | 90 days | 90 days |  |  |
Exosomes License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Notice period |  |  |  | 90 days | 90 days |  |  |
Minimum | Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Share of product revenue (in percent) |  |  |  |  |  |  |  | 30.00%
Minimum | Rome License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Minimum annual royalty payments | € |  |  |  |  | € 20,000 |  |  |
Maximum | Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Potential milestone payments |  |  |  |  |  |  |  | $ 605,000,000
Share of product revenue (in percent) |  |  |  |  |  |  |  | 50.00%
Maximum | JHU License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Potential milestone payments |  | 1,850,000 |  | $ 1,850,000 |  |  |  |
Completion Of Phase Three | JHU License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Milestone payments to be made upon completion of certain phases |  |  |  |  |  |  | 500,000 |
Obtention of FDA Approval | JHU License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Milestone payments to be made upon completion of certain phases |  |  |  |  |  |  | 1,000,000 |
Completion Of Phase Two Due | JHU License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Milestones paid |  |  |  |  |  |  | $ 250,000 |
First Milestone Payment |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Milestone payments to be made upon completion of certain phases |  | 10,000,000 |  | 10,000,000 |  |  |  |
First Milestone Payment | Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Milestone payments to be made upon completion of certain phases |  | 10,000,000 |  | 10,000,000 |  |  |  |
Upfront payment |  |  |  | 30,000,000 |  |  |  |
First Milestone Payment | CSMC | Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Recognized as revenue |  |  |  | 40,000,000 |  |  |  |
Deferred revenue liability |  | 40,000,000 |  | 40,000,000 |  |  |  |
Second Milestone Payment | Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Milestones paid |  | 10,000,000 |  |  |  |  |  |
Upfront payment |  |  |  | 30,000,000 |  |  |  |
Deferred revenue, current |  | 0 |  | 0 |  |  |  |
Second Milestone Payment | CSMC | Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Deferred revenue liability |  | 50,000,000 |  | 50,000,000 |  |  |  |
Development Milestone Payment, One | Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Milestone payments to be made upon completion of certain phases |  | 10,000,000 |  | 10,000,000 |  |  |  |
Development Milestone Payment, Two | Commercialization and Distribution Agreement with Nippon Shinyaku Co, Limited, United States |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Milestone payments to be made upon completion of certain phases |  | $ 10,000,000 |  | $ 10,000,000 |  |  |  |
Patent rights | JHU License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Agreement effective period |  |  |  | 20 years | 20 years |  |  |
Non Payment of Royalties | CSMC License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Agreement termination period |  |  |  | 30 days | 30 days |  |  |
Non Payment of Royalties | Exosomes License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Threshold period to cure breach |  |  |  | 30 days | 30 days |  |  |
CSMC Agreement Compliance | CSMC License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Agreement termination period |  |  |  | 90 days | 90 days |  |  |
CSMC Agreement Compliance | Exosomes License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Threshold period to cure breach |  |  |  | 90 days | 90 days |  |  |
Material Breach Has Not Been Cured | CSMC License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Agreement termination period |  |  |  | 90 days | 90 days |  |  |
Material Breach Has Not Been Cured | Exosomes License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Threshold period to cure breach |  |  |  | 90 days | 90 days |  |  |
Fails To Cure Breach after Notice From CSMC | CSMC License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Agreement termination period |  |  |  | 90 days | 90 days |  |  |
Fails To Cure Breach after Notice From CSMC | Exosomes License Agreement |  |  |  |  |  |  |  |
LICENSE AGREEMENTS |  |  |  |  |  |  |  |
Threshold period to cure breach |  |  |  | 90 days | 90 days |  |  |

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