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Stock Incentive Plans and Stock Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2011
Stock Option Activity | The following table summarizes all stock option activity for the year ended December 31, 2011:
|  | Number of Shares |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term |  |  | Aggregate Intrinsic Value |
|  | (in thousands, except for per share amounts) |
Outstanding January 1, 2011 |  |  | 10,028 |  |  | $ | 2.69 |  |  |  |  |  |  |  |  |
Granted |  |  | 4,445 |  |  |  | 10.53 |  |  |  |  |  |  |  |  |
Cancelled/Expired |  |  | (328 | ) |  |  | 16.43 |  |  |  |  |  |  |  |  |
Exercised |  |  | (2,274 | ) |  |  | 2.27 |  |  |  |  |  |  |  |  |
Outstanding, December 31, 2011 |  |  | 11,871 |  |  | $ | 5.33 |  |  |  | 8.68 years |  |  | $ | 40,475 |
Exercisable, December 31, 2011 |  |  | 3,495 |  |  | $ | 2.69 |  |  |  | 8.09 years |  |  | $ | 17,972 |
Vested and Expected to Vest, December 31, 2011 |  |  | 11,787 |  |  | $ | 5.32 |  |  |  | 8.68 years |  |  | $ | 40,250 |
Available for future grant at December 31, 2011 |  |  | 2,231 |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-Based Compensation Expense Related to Option Awards | The following table presents the stock-based compensation expense related to option awards for the period ended December 31:
|  | 2011 |  |  | 2010 |  |  | 2009 |
|  | (in thousands) |
Research and development |  | $ | 1,464 |  |  | $ | 1,534 |  |  | $ | 1,481 |
General and administrative |  |  | 7,830 |  |  |  | 3,673 |  |  |  | 1,378 |
Stock-based compensation expense |  | $ | 9,294 |  |  | $ | 5,207 |  |  | $ | 2,859 |
Assumptions Used to Estimate Fair Value of Share-Based Payment Awards | For 2011, 2010 and 2009, the Company used the following assumptions to estimate the fair value of share-based payment awards:
|  | 2011 |  | 2010 |  | 2009
Risk free interest rate |  | 2.03% - 2.56% |  | 1.5% - 3.1% |  | 2.5% - 3.0%
Expected dividend yield |  | 0.00% |  | 0.00% |  | 0.00%
Expected option life (years) |  | 6.25 |  | 5.75 - 6.25 |  | 5.75 - 6.25
Expected volatility |  | 105% - 112% |  | 105% - 110% |  | 105% - 110%

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=6793087&loc=d3e301413-122809 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph A240 -Subparagraph g(1) -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph 64 -Subparagraph b -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Topic 718 -SubTopic 10 -Publisher FASB -Number -Article -Subparagraph (c)(1) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Topic 718 -SubTopic 10 -Publisher FASB -Number -Article -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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