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Equity - Additional Information (Detail) (USD $) | 1 Months Ended | 12 Months Ended | 1 Months Ended |  | 1 Months Ended |  | 12 Months Ended |  |  | 1 Months Ended
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jan. 31, 2011 | Dec. 31, 2011 | Dec. 31, 2010 | Dec. 31, 2009 | Aug. 31, 2009 Ester Neurosciences Ltd | Oct. 31, 2009 Bridge Loan | Oct. 31, 2009 October 2009 Private Placement Point | Oct. 31, 2009 October 2009 Private Placement Bridge Loan Point | Oct. 16, 2009 October 2009 Private Placement Bridge Loan | Dec. 31, 2011 October 2009 Private Placement Warrants Issued October 2009 | Dec. 31, 2010 October 2009 Private Placement Warrants Issued October 2009 | Oct. 16, 2010 October 2009 Private Placement Warrants Issued October 2009 American Depositary Share | Oct. 16, 2009 October 2009 Private Placement Warrants Issued October 2009 American Depositary Share | Oct. 16, 2009 October 2009 Private Placement Warrants Issued October 2009 Bridge Loan | Oct. 31, 2009 Proseed Capital Holdings
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued, shares | 13,800,000 |  |  |  | 1,315,789 |  | 66,400,000 | 4,000,000 |  |  |  |  |  |  | 39,473
Number of shares that each ADS represents |  |  |  |  |  |  | 1 | 1 |  |  |  |  |  |  |
Common stock issued under private placement, value |  | $ 98,654,000 |  | $ 62,253,000 | $ 1,800,000 |  | $ 70,000,000 |  |  |  |  |  |  |  |
Common stock issued, price per share | $ 7.60 |  |  |  |  |  | $ 1.0 |  |  |  |  |  |  |  |
Gross proceed from common shares issued | 104,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceed from common shares issued | 98,654,000 | 98,654,000 |  | 62,253,000 |  |  |  |  |  |  |  |  |  |  |
Shares issued, exercise of stock options |  | 2,273,221 |  |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds from exercise of stock options |  | 5,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds from exercise of stock options |  | 5,094,000 | 3,642,000 |  |  |  |  |  |  |  |  |  |  |  |
Shares issued, exercise of warrants |  | 12,888,369 |  |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds from exercise of warrants |  | 19,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds from exercise of warrants |  | 18,702,000 | 8,904,000 |  |  |  |  |  |  | 18,100,000 | 8,000,000 |  |  |  |
Common stock issued under private placement, net proceeds |  |  |  |  |  |  | 62,253,000 |  |  |  |  |  |  |  |
Bridge notes converted in conjunction with the private placement, amount |  |  |  |  |  |  |  | 3,600,000 |  |  |  |  |  |  |
Bridge notes converted in conjunction with the private placement, shares of common stock issued |  |  |  |  |  |  |  | 3,999,996 |  |  |  |  |  |  |
Warrant term |  |  |  |  |  |  |  |  |  |  |  | 5 years | 5 years | 5 years |
Warrants issued, number of shares called by the warrant |  |  |  |  |  |  |  | 1,999,996 | 1,999,996 |  |  | 0.5 | 0.5 | 0.5 |
Exercise price of the warrants |  | 1.48 |  |  |  |  |  | 1.50 | 1.50 |  |  | 1.50 | 1.50 | 1.50 |
Outstanding bridge loan notes |  |  |  |  |  | $ 5,500,000 |  |  |  |  |  |  |  |  |

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