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Related Party Transactions - Additional Information (Detail) | 1 Months Ended |  | 1 Months Ended | 12 Months Ended |  | 12 Months Ended | 1 Months Ended | 3 Months Ended | 12 Months Ended |  | 1 Months Ended |  |  | 1 Months Ended | 12 Months Ended
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Jan. 31, 2011 | Dec. 31, 2011 | Oct. 31, 2009 Mr Thomas Lynch | Dec. 31, 2009 Mr Thomas Lynch USD ($) | Oct. 16, 2009 Mr Thomas Lynch USD ($) | Dec. 31, 2009 Elan Pharma International Ltd USD ($) | Jan. 31, 2009 Dalriada Ltd Agreement USD ($) | Mar. 31, 2007 Dalriada Ltd Agreement GBP (£) | Dec. 31, 2007 Dalriada Ltd Agreement USD ($) | Dec. 31, 2007 Dalriada Ltd Agreement GBP (£) | Jan. 31, 2009 Dalriada Ltd Agreement EUR (€) | Oct. 31, 2009 Mr Alan Cooke USD ($) | Oct. 31, 2009 Mr Alan Cooke EUR (€) | Oct. 16, 2009 Mr Alan Cooke USD ($) | Dec. 31, 2011 October 2009 Private Placement Warrant USD ($) | Oct. 31, 2009 October 2009 Private Placement American Depository Share USD ($) Point | Oct. 31, 2009 October 2009 Private Placement American Depository Share Abingworth LLP USD ($) | Oct. 31, 2009 October 2009 Private Placement American Depository Share Orbimed Advisors LLC USD ($) | Oct. 31, 2009 October 2009 Private Placement American Depository Share Sofinnova Venture Partners VII, LP USD ($) | Oct. 31, 2009 October 2009 Private Placement American Depository Share Fountain Healthcare Partners Fund 1, LP USD ($) | Dec. 31, 2011 June 2009 Convertible Bridge Loans Dr John Climax USD ($) | Dec. 31, 2011 June 2009 Convertible Bridge Loans Mr Thomas Lynch USD ($) | Dec. 31, 2011 July 2009 Convertible Bridge Loans Dr John Climax USD ($) | Dec. 31, 2011 July 2009 Convertible Bridge Loans Mr Thomas Lynch | Dec. 31, 2011 July 2009 Convertible Bridge Loans Mr Thomas Lynch Exercise Price 1 | Dec. 31, 2011 July 2009 Convertible Bridge Loans Mr Thomas Lynch Exercise Price 2
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase of ADSs (in the form of common stock) by directors in private placement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 36,000,000 | $ 17,000,000 | $ 7,000,000 | $ 7,000,000 | $ 5,000,000 |  |  |  |  |  |
Number of ADS that can be purchased for each warrant received |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.5 |  |  |  |  |  |  |  |  |  |
Termination payment |  |  |  |  |  |  |  |  |  |  |  | 607,500 | 375,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant derivative liability |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 123,100,000 |  |  |  |  |  |  |  |  |  |  |
Warrants issued |  |  | 500,000 |  |  |  |  |  |  |  |  | 247,050 | 247,050 |  |  |  |  |  |  |  |  |  |  | 277,776 | 138,888 | 138,888
Financing amount |  |  |  | 70,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant derivative liability, fair value |  |  |  |  | 669,000 |  |  |  |  |  |  |  |  | 331,000 | 102,000,000 |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  | 1.48 |  |  |  |  |  |  |  |  |  |  |  | 1.50 |  |  |  |  |  |  |  |  |  |  | 1.00 | 1.50
Warrants issued, exercisable period |  |  |  |  |  |  |  |  |  |  |  | 5 years | 5 years |  |  |  |  |  |  |  |  |  |  | 5 years |  |
Loans purchased by director |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,000,000 | 300,000 | 1,000,000 |  |  |
Proceed from sale of the development and license agreement |  |  |  |  |  | 700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Annual Payment under agreement for consultancy services |  |  |  |  |  |  | 400,000 | 240,000 |  |  | 300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional performance related payment |  |  |  |  |  |  |  | 195,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment under service agreement |  |  |  |  |  |  | $ 100,000 |  | $ 121,500 | £ 75,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued | 13,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 277,777 |  |  |  |

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