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Warrants and Derivative Liability - Additional Information (Detail) (USD $) | 1 Months Ended | 12 Months Ended |  |  | 12 Months Ended |  | 12 Months Ended |  |  | 12 Months Ended |  |  |  | 1 Months Ended |  | 12 Months Ended |  |  |  |  | 12 Months Ended |  | 12 Months Ended |  | 1 Months Ended |  | 1 Months Ended |  | 12 Months Ended |  |  |  | 12 Months Ended |  |
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Jan. 31, 2011 | Dec. 31, 2011 | Dec. 31, 2010 | Dec. 31, 2009 | Jul. 31, 2009 | Dec. 31, 2008 | Dec. 31, 2011 Warrant Issued to Employees | Dec. 31, 2010 Warrant Issued to Employees | Dec. 31, 2009 Warrant Issued to Employees | Dec. 31, 2011 Warrants Issued October 2009 | Dec. 31, 2010 Warrants Issued October 2009 | Dec. 31, 2009 Warrants Issued October 2009 | Oct. 31, 2009 Warrants Issued October 2009 | Dec. 31, 2011 Warrants Issued October 2009 Warrant Issued to Employees | Dec. 31, 2010 Warrants Issued October 2009 Warrant Issued to Employees | Dec. 31, 2009 Warrants Issued October 2009 Warrant Issued to Employees | Dec. 31, 2009 Warrants Issued June and July 2009 | Oct. 31, 2009 Warrants Issued June and July 2009 | Jul. 31, 2009 Warrants Issued June and July 2009 | Dec. 31, 2009 Warrants Issued December 2007 | Dec. 06, 2009 Warrants Issued December 2007 | Dec. 31, 2008 Warrants Issued December 2007 | Dec. 31, 2007 Warrants Issued December 2007 | Oct. 31, 2009 October 2009 Private Placement Point | Oct. 31, 2009 October 2009 Private Placement Bridge Loan Point | Oct. 16, 2009 October 2009 Private Placement Bridge Loan | Dec. 31, 2011 October 2009 Private Placement Warrants Issued October 2009 | Dec. 31, 2010 October 2009 Private Placement Warrants Issued October 2009 | Dec. 31, 2009 October 2009 Private Placement Warrants Issued October 2009 | Oct. 16, 2009 October 2009 Private Placement Warrants Issued October 2009 | Dec. 31, 2009 October 2009 Private Placement Warrants Issued October 2009 Maximum | Oct. 16, 2010 October 2009 Private Placement Warrants Issued October 2009 American Depositary Share | Oct. 16, 2009 October 2009 Private Placement Warrants Issued October 2009 American Depositary Share | Dec. 31, 2011 October 2009 Private Placement Warrants Issued October 2009 Warrant Issued to Employees | Dec. 31, 2010 October 2009 Private Placement Warrants Issued October 2009 Warrant Issued to Employees | Dec. 31, 2009 October 2009 Private Placement Warrants Issued October 2009 Warrant Issued to Employees | Oct. 16, 2009 October 2009 Private Placement Warrants Issued October 2009 Warrant Issued to Employees Person | Oct. 16, 2009 October 2009 Private Placement Warrants Issued October 2009 Bridge Loan | Oct. 16, 2009 October 2009 Private Placement Warrants Issued June and July 2009 | Dec. 31, 2009 October 2009 Private Placement Warrants Issued June and July 2009 Bridge Loan | Jun. 30, 2009 June 2009 Private Placement Convertible 8 Percent Bridge Loans, due August 2009 | Jun. 30, 2009 June 2009 Private Placement Warrants Issued June and July 2009 Convertible 8 Percent Bridge Loans, due August 2009 | Jun. 30, 2009 June 2009 Private Placement Warrants Issued June 2009 | Jul. 31, 2009 July 2009 Private Placement Convertible 8 Percent Bridge Loans, due August 2009 | Jul. 31, 2009 July 2009 Private Placement Convertible 8 Percent Bridge Loans, due September 2009 | Jul. 31, 2009 July 2009 Private Placement Warrants Issued June and July 2009 Convertible 8 Percent Bridge Loans, due September 2009 | Jul. 31, 2009 July 2009 Private Placement Warrants Issued June 2009 Convertible 8 Percent Bridge Loans, due August 2009 | Jul. 31, 2009 July 2009 Private Placement Warrants Issued June 2009 Convertible 8 Percent Bridge Loans, due September 2009 | Jul. 31, 2009 July 2009 Private Placement Warrants Issued July 2009 | Dec. 31, 2009 June and July 2009 Private Placement Bridge Loan | Oct. 16, 2009 June and July 2009 Private Placement Bridge Loan | Jul. 31, 2009 June and July 2009 Private Placement Bridge Loan | Jun. 30, 2009 June and July 2009 Private Placement Bridge Loan | Dec. 31, 2009 December 2007 Direct Public Offering Warrants Issued December 2007 | Dec. 31, 2008 December 2007 Direct Public Offering Warrants Issued December 2007 | Dec. 06, 2009 December 2007 Direct Public Offering Warrants Issued December 2007 | Dec. 31, 2007 December 2007 Direct Public Offering Warrants Issued December 2007 | Dec. 31, 2007 December 2007 Direct Public Offering Warrants Issued December 2007 Scenario, Previously Reported | Dec. 31, 2007 December 2007 Direct Public Offering Warrants Issued December 2007 Scenario, Restated
Derivative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued under private placement, value |  | $ 98,654,000 |  | $ 62,253,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 70,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued under private placement, net proceeds |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 62,253,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Bridge notes converted in conjunction with the private placement, amount |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Bridge notes converted in conjunction with the private placement, shares of common stock issued |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,999,996 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued under private placement, shares | 13,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 66,400,000 | 4,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares that each ADS represents |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Bridge notes converted in conjunction with the private placement, price per share |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.90 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued under private placement, price per share | $ 7.60 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercised, number of warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 12,100,000 | 5,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants issued |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 35,200,000 |  |  |  |  |  |  | 900,000 |  |  |  |  | 1,444,442 |  |  |  | 1,666,663 |  | 1,388,887 |  |  |  |  |  |  |  |  | 1,000,000 |  |
Warrant term |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years | 5 years |  |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Description of pricing variability feature and classification of warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | The warrants issued in connection with the October 2009 financing contained a pricing variability feature which provided for an increase to the exercise price if the exchange rate between the U.S. dollar and British pound adjusts such that the warrants could be exercised at a price less than the £0.5 par value of the common stock – that is, if the exchange rate exceeded U.S. $3.00 per £1.0 sterling. Due to the potential variable nature of the exercise price, the warrants are not considered to be indexed to the Company’s common stock. Accordingly, the warrants do not qualify for the exception to classify the warrants within equity and are classified as a derivative liability. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercised, gross proceeds |  | 18,702,000 | 8,904,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 18,100,000 | 8,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of officers |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants issued, number of shares called by the warrant |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,999,996 | 1,999,996 |  |  |  |  | 36,100,000 | 0.5 | 0.5 |  |  |  |  | 0.5 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of the warrant derivative liability reclassified from liabilities to equity |  | 129,517,000 | 22,317,000 | 5,328,000 |  |  |  |  |  | 129,517,000 | 22,317,000 |  |  |  |  |  | 4,316,000 |  |  | 1,012,000 |  |  |  |  |  |  | 129,517,000 | 22,317,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (1,012,000) |  |  |  |  |
Exercise price of the warrants |  | 1.48 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1.50 | 1.50 |  |  |  |  |  | 1.50 | 1.50 |  |  |  |  | 1.50 |  |  |  | 1 |  |  |  | 1.00 |  | 1.00 |  |  |  |  |  |  |  |  |  | 4.80 | 1.17
Fair value of derivative liability |  | 123,125,000 | 230,069,000 | 41,520,000 | 2,800,000 | 1,037,000 |  |  |  | 123,125,000 | 230,069,000 | 41,520,000 | 48,300,000 |  |  |  |  | 4,300,000 | 2,800,000 |  | 1,000,000 | 533,000 | 2,500,000 |  |  |  | 123,125,000 | 230,069,000 | 41,520,000 | 47,100,000 |  |  |  |  |  |  | 1,200,000 |  |  |  |  |  | 1,300,000 |  |  |  |  |  | 1,500,000 |  |  |  |  |  | 533,000 | 1,000,000 | 2,108,000 |  |
(Gain) loss on change in fair value of derivative liability |  | (22,669,000) | (205,153,000) | 5,137,000 |  |  |  |  |  | (22,669,000) | (205,153,000) | 6,625,000 |  |  |  |  | (1,513,000) |  |  | (479,000) |  |  |  |  |  |  | 22,669,000 | 205,153,000 | (6,625,000) |  |  |  |  |  |  |  |  |  |  | 1,513,000 |  |  |  |  |  |  |  |  |  |  |  |  |  | 479,000 | (1,575,000) |  |  |  |
Compensation (income) expense |  | 9,294,000 | 5,207,000 | 2,859,000 |  |  | 96,000 | (5,713,000) | 170,000 | (100,000) | 5,713,000 |  |  | 96,000 | (5,713,000) | 170,000 |  |  |  |  |  |  |  |  |  |  |  |  | (170,000) |  |  |  |  | (100,000) | 5,713,000 | 1,210,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loan payable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,800,000 | 1,900,000 |  |  |  |  |  |
Convertible bridge loans issued under private placement, face amount |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,600,000 |  |  |  | 3,000,000 |  |  |  |  |  | 5,500,000 | 5,600,000 |  |  |  |  |  |  |
Interest expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,800,000 |  |  |  |  |  |  |  |  |
Convertible bridge loans issued under private placement, interest rate |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 8.00% |  |  |  | 8.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Repayment of bridge notes |  |  |  | 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants cancelled |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,388,887 |  |  |  |  |  |  |  |  |  |  |  |
Outstanding bridge loan notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,500,000 |  |  |  |  |  |  |  |
Fair value of derivative liability |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 4,316,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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- Definition The number of warrants or rights which entitle the entity to receive future services in exchange for the unvested, forfeitable warrants or rights. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Emerging Issues Task Force (EITF) -Number D-90 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 50 -Section S99 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6784392&loc=d3e188667-122775 + Details
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