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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (USD $) In Thousands, except Per Share data, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2011 | Dec. 31, 2010 | Dec. 31, 2009
Revenues |  |  |
Operating Expenses: |  |  |
Research and development | 21,602 | 28,014 | 20,892
General and administrative | 22,559 | 17,087 | 13,152
Total operating expenses | 44,161 | 45,101 | 34,044
Operating loss | (44,161) | (45,101) | (34,044)
(Loss) gain on change in fair value of derivative liability | (22,669) | (205,153) | 5,137
Interest expense | (1) | (19) | (2,832)
Interest income | 231 | 53 | 199
Other (expense) income, net | (10) | 130 | 33
Loss from operations before taxes | (66,610) | (250,090) | (31,507)
(Provision for) benefit from income taxes | (2,516) | 501 | 901
Net and comprehensive loss | $ (69,126) | $ (249,589) | $ (30,606)
Loss per basic and diluted share: | $ (0.53) | $ (2.49) | $ (0.72)
Weighted average shares: |  |  |
Basic and diluted | 130,247 | 100,239 | 42,424

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