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Commitments and Contingencies - Additional Information (Detail) | 12 Months Ended | 1 Months Ended |  | 1 Months Ended |  |  |  | 12 Months Ended |  | 12 Months Ended |  | 1 Months Ended | 12 Months Ended |
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Dec. 31, 2011 USD ($) | Dec. 31, 2010 USD ($) | Dec. 31, 2009 USD ($) | Dec. 31, 2008 USD ($) | Dec. 31, 2011 Amr One Hundred One USD ($) Contract | Dec. 31, 2011 Amr One Hundred One Maximum USD ($) | Dec. 31, 2011 Amr One Hundred One Maximum Initial Payment USD ($) | Jul. 31, 2011 Chemport USD ($) | Dec. 31, 2011 Chemport USD ($) | Oct. 31, 2011 Elan USD ($) | Dec. 31, 2009 Elan USD ($) | Dec. 31, 2011 Up On First Marketing Approval of AMR101 USD ($) | Dec. 31, 2011 Net sales up to GBP100 million ($162.0 million at December 31, 2010) Laxdale Limited | Dec. 31, 2011 Net sales up to GBP100 million ($162.0 million at December 31, 2010) Laxdale Limited Maximum USD ($) | Dec. 31, 2011 Net sales up to GBP100 million ($162.0 million at December 31, 2010) Laxdale Limited Maximum GBP (£) | Dec. 31, 2011 Net sales between GBP100 million ($162.0 million) and GBP500 million ($810.0 million) Laxdale Limited | Dec. 31, 2011 Net sales between GBP100 million ($162.0 million) and GBP500 million ($810.0 million) Laxdale Limited Maximum USD ($) | Dec. 31, 2011 Net sales between GBP100 million ($162.0 million) and GBP500 million ($810.0 million) Laxdale Limited Maximum GBP (£) | Dec. 31, 2011 Net sales between GBP100 million ($162.0 million) and GBP500 million ($810.0 million) Laxdale Limited Minimum USD ($) | Dec. 31, 2011 Net sales between GBP100 million ($162.0 million) and GBP500 million ($810.0 million) Laxdale Limited Minimum GBP (£) | Dec. 31, 2011 Net sales in excess of GBP500 million Laxdale Limited | Dec. 31, 2011 Net sales in excess of GBP500 million Laxdale Limited Minimum USD ($) | Dec. 31, 2011 Net sales in excess of GBP500 million Laxdale Limited Minimum GBP (£) | Dec. 31, 2011 First Indication for AMR101 Laxdale Limited Potential Marketing Approval 1 USD ($) | Dec. 31, 2011 First Indication for AMR101 Laxdale Limited Potential Marketing Approval 1 GBP (£) | Dec. 31, 2011 First Indication for AMR101 Laxdale Limited Potential Marketing Approval 2 USD ($) | Dec. 31, 2011 First Indication for AMR101 Laxdale Limited Potential Marketing Approval 2 GBP (£) | Dec. 31, 2011 First Indication for AMR101 Laxdale Limited Maximum USD ($) | Dec. 31, 2011 First Indication for AMR101 Laxdale Limited Maximum GBP (£) | Dec. 31, 2011 Further Indication for AMR101 Laxdale Limited Potential Marketing Approval 1 USD ($) | Dec. 31, 2011 Further Indication for AMR101 Laxdale Limited Potential Marketing Approval 1 GBP (£) | Dec. 31, 2011 Further Indication for AMR101 Laxdale Limited Potential Marketing Approval 2 USD ($) | Dec. 31, 2011 Further Indication for AMR101 Laxdale Limited Potential Marketing Approval 2 GBP (£) | Dec. 31, 2011 Further Indication for AMR101 Laxdale Limited Maximum USD ($) | Dec. 31, 2011 Further Indication for AMR101 Laxdale Limited Maximum GBP (£) | Dec. 31, 2011 Contract Termination USD ($) | Dec. 31, 2010 Contract Termination USD ($) | Dec. 31, 2011 Groton | Nov. 28, 2011 Groton USD ($) Year sqft | Dec. 31, 2011 Dublin | Sep. 30, 2011 Dublin USD ($) Year sqft | Sep. 30, 2011 Dublin EUR (€) | Dec. 31, 2011 Bedminster sqft | Dec. 31, 2011 Bedminster | May 31, 2011 Bedminster USD ($) sqft
Commitments and Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Office space leased (in square feet) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,327 |  | 320 | 320 |  |  | 9,747
Operating lease, term |  | 3 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating lease, term |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |
Operating lease, monthly rent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 8,500 |  | $ 3,500 | € 2,700 |  |  | $ 21,931
Operating lease, expiration date |  | 2011-10-31 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2012-10-31 |  |  |  | 2014-06-30 |
Operating lease, renewal option |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 |  | 1 | 1 |  |  |
Additional office space leased (in square feet) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,142 |  |
Operating lease, rental expense |  | 500,000 | 300,000 | 300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase in monthly rent in each of years four, five and six |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3.00% |  |  |  |  |  |  |
Liabilities for exited lease facilities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 | 100,000 |  |  |  |  |  |  |  |
One-time non refundable payment due to the supplier |  |  |  |  |  |  |  |  |  |  |  | 500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum penalty if the company is not successful in obtaining NDA approval for AMR101 |  |  | 5,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of signed agreements |  |  |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development fees committed |  |  |  |  |  | 500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Raw material purchase commitment |  |  |  |  | 1,100,000 |  | 5,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Minority share equity investment commitment |  |  |  |  |  |  |  |  | 3,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash paid for cost method investment | 1,650,000 |  |  |  |  |  |  | 1,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  |  |  |  |  |  |  |  |  | 200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  |  |  |  |  |  | 200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential royalty payment as a percentage of net sales |  |  |  |  |  |  |  |  |  |  |  |  | 1.00% |  |  | 0.50% |  |  |  |  | 0.25% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net sales for potential royalty payments |  |  |  |  |  |  |  |  |  |  |  |  |  | 155,000,000 | 100,000,000 |  | 773,000,000 | 500,000,000 | 155,000,000 | 100,000,000 |  | 773,000,000 | 500,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential aggregate stock or cash payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 11,600,000 | £ 7,500,000 | $ 11,600,000 | £ 7,500,000 | $ 23,200,000 | £ 15,000,000 | $ 7,700,000 | £ 5,000,000 | $ 7,700,000 | £ 5,000,000 | $ 15,500,000 | £ 10,000,000 |  |  |  |  |  |  |  |  |  |

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