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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (USD $)
In Thousands, except Per Share data, unless otherwise specified
 12 Months Ended
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Revenues         
Operating Expenses:      
Research and development 21,602 28,014 20,892
General and administrative 22,559 17,087 13,152
Total operating expenses 44,161 45,101 34,044
Operating loss (44,161) (45,101) (34,044)
(Loss) gain on change in fair value of derivative liability (22,669) (205,153) 5,137
Interest expense (1) (19) (2,832)
Interest income 231 53 199
Other (expense) income, net (10) 130 33
Loss from operations before taxes (66,610) (250,090) (31,507)
(Provision for) benefit from income taxes (2,516) 501 901
Net and comprehensive loss $ (69,126) $ (249,589) $ (30,606)
Loss per basic and diluted share: $ (0.53) $ (2.49) $ (0.72)
Weighted average shares:      
Basic and diluted 130,247 100,239 42,424