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Warrants and Derivative Liability - Additional Information (Detail) (USD $)
 1 Months Ended 12 Months Ended 12 Months Ended 12 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended 12 Months Ended 12 Months Ended 1 Months Ended 1 Months Ended 12 Months Ended 12 Months Ended
Jan. 31, 2011
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Jul. 31, 2009
Dec. 31, 2008
Dec. 31, 2011
Warrant Issued to Employees
Dec. 31, 2010
Warrant Issued to Employees
Dec. 31, 2009
Warrant Issued to Employees
Dec. 31, 2011
Warrants Issued October 2009
Dec. 31, 2010
Warrants Issued October 2009
Dec. 31, 2009
Warrants Issued October 2009
Oct. 31, 2009
Warrants Issued October 2009
Dec. 31, 2011
Warrants Issued October 2009
Warrant Issued to Employees
Dec. 31, 2010
Warrants Issued October 2009
Warrant Issued to Employees
Dec. 31, 2009
Warrants Issued October 2009
Warrant Issued to Employees
Dec. 31, 2009
Warrants Issued June and July 2009
Oct. 31, 2009
Warrants Issued June and July 2009
Jul. 31, 2009
Warrants Issued June and July 2009
Dec. 31, 2009
Warrants Issued December 2007
Dec. 06, 2009
Warrants Issued December 2007
Dec. 31, 2008
Warrants Issued December 2007
Dec. 31, 2007
Warrants Issued December 2007
Oct. 31, 2009
October 2009 Private Placement
Point
Oct. 31, 2009
October 2009 Private Placement
Bridge Loan
Point
Oct. 16, 2009
October 2009 Private Placement
Bridge Loan
Dec. 31, 2011
October 2009 Private Placement
Warrants Issued October 2009
Dec. 31, 2010
October 2009 Private Placement
Warrants Issued October 2009
Dec. 31, 2009
October 2009 Private Placement
Warrants Issued October 2009
Oct. 16, 2009
October 2009 Private Placement
Warrants Issued October 2009
Dec. 31, 2009
October 2009 Private Placement
Warrants Issued October 2009
Maximum
Oct. 16, 2010
October 2009 Private Placement
Warrants Issued October 2009
American Depositary Share
Oct. 16, 2009
October 2009 Private Placement
Warrants Issued October 2009
American Depositary Share
Dec. 31, 2011
October 2009 Private Placement
Warrants Issued October 2009
Warrant Issued to Employees
Dec. 31, 2010
October 2009 Private Placement
Warrants Issued October 2009
Warrant Issued to Employees
Dec. 31, 2009
October 2009 Private Placement
Warrants Issued October 2009
Warrant Issued to Employees
Oct. 16, 2009
October 2009 Private Placement
Warrants Issued October 2009
Warrant Issued to Employees
Person
Oct. 16, 2009
October 2009 Private Placement
Warrants Issued October 2009
Bridge Loan
Oct. 16, 2009
October 2009 Private Placement
Warrants Issued June and July 2009
Dec. 31, 2009
October 2009 Private Placement
Warrants Issued June and July 2009
Bridge Loan
Jun. 30, 2009
June 2009 Private Placement
Convertible 8 Percent Bridge Loans, due August 2009
Jun. 30, 2009
June 2009 Private Placement
Warrants Issued June and July 2009
Convertible 8 Percent Bridge Loans, due August 2009
Jun. 30, 2009
June 2009 Private Placement
Warrants Issued June 2009
Jul. 31, 2009
July 2009 Private Placement
Convertible 8 Percent Bridge Loans, due August 2009
Jul. 31, 2009
July 2009 Private Placement
Convertible 8 Percent Bridge Loans, due September 2009
Jul. 31, 2009
July 2009 Private Placement
Warrants Issued June and July 2009
Convertible 8 Percent Bridge Loans, due September 2009
Jul. 31, 2009
July 2009 Private Placement
Warrants Issued June 2009
Convertible 8 Percent Bridge Loans, due August 2009
Jul. 31, 2009
July 2009 Private Placement
Warrants Issued June 2009
Convertible 8 Percent Bridge Loans, due September 2009
Jul. 31, 2009
July 2009 Private Placement
Warrants Issued July 2009
Dec. 31, 2009
June and July 2009 Private Placement
Bridge Loan
Oct. 16, 2009
June and July 2009 Private Placement
Bridge Loan
Jul. 31, 2009
June and July 2009 Private Placement
Bridge Loan
Jun. 30, 2009
June and July 2009 Private Placement
Bridge Loan
Dec. 31, 2009
December 2007 Direct Public Offering
Warrants Issued December 2007
Dec. 31, 2008
December 2007 Direct Public Offering
Warrants Issued December 2007
Dec. 06, 2009
December 2007 Direct Public Offering
Warrants Issued December 2007
Dec. 31, 2007
December 2007 Direct Public Offering
Warrants Issued December 2007
Dec. 31, 2007
December 2007 Direct Public Offering
Warrants Issued December 2007
Scenario, Previously Reported
Dec. 31, 2007
December 2007 Direct Public Offering
Warrants Issued December 2007
Scenario, Restated
Derivative [Line Items]                                                                                                                      
Common stock issued under private placement, value   $ 98,654,000   $ 62,253,000                                       $ 70,000,000                                                                      
Common stock issued under private placement, net proceeds                                               62,253,000                                                                      
Bridge notes converted in conjunction with the private placement, amount                                                 3,600,000                                                                    
Bridge notes converted in conjunction with the private placement, shares of common stock issued                                                 3,999,996                                                                    
Common stock issued under private placement, shares 13,800,000                                             66,400,000 4,000,000                                                                    
Number of shares that each ADS represents                                               1 1                                                                    
Bridge notes converted in conjunction with the private placement, price per share                                                   $ 0.90                                                                  
Common stock issued under private placement, price per share $ 7.60                                             $ 1.0                                                                      
Warrants exercised, number of warrants                                                     12,100,000 5,300,000                                                              
Number of warrants issued                                                           35,200,000             900,000         1,444,442       1,666,663   1,388,887                 1,000,000    
Warrant term                                                               5 years 5 years         5 years                                          
Description of pricing variability feature and classification of warrants                                                         The warrants issued in connection with the October 2009 financing contained a pricing variability feature which provided for an increase to the exercise price if the exchange rate between the U.S. dollar and British pound adjusts such that the warrants could be exercised at a price less than the £0.5 par value of the common stock – that is, if the exchange rate exceeded U.S. $3.00 per £1.0 sterling. Due to the potential variable nature of the exercise price, the warrants are not considered to be indexed to the Company’s common stock. Accordingly, the warrants do not qualify for the exception to classify the warrants within equity and are classified as a derivative liability.                                                            
Warrants exercised, gross proceeds   18,702,000 8,904,000                                               18,100,000 8,000,000                                                              
Number of officers                                                                         3                                            
Warrants issued, number of shares called by the warrant                                                 1,999,996 1,999,996         36,100,000 0.5 0.5         0.5                                          
Fair value of the warrant derivative liability reclassified from liabilities to equity   129,517,000 22,317,000 5,328,000           129,517,000 22,317,000           4,316,000     1,012,000             129,517,000 22,317,000                                                   (1,012,000)          
Exercise price of the warrants   1.48                                             1.50 1.50           1.50 1.50         1.50       1       1.00   1.00                   4.80 1.17
Fair value of derivative liability   123,125,000 230,069,000 41,520,000 2,800,000 1,037,000       123,125,000 230,069,000 41,520,000 48,300,000         4,300,000 2,800,000   1,000,000 533,000 2,500,000       123,125,000 230,069,000 41,520,000 47,100,000             1,200,000           1,300,000           1,500,000           533,000 1,000,000 2,108,000    
(Gain) loss on change in fair value of derivative liability   (22,669,000) (205,153,000) 5,137,000           (22,669,000) (205,153,000) 6,625,000         (1,513,000)     (479,000)             22,669,000 205,153,000 (6,625,000)                     1,513,000                           479,000 (1,575,000)        
Compensation (income) expense   9,294,000 5,207,000 2,859,000     96,000 (5,713,000) 170,000 (100,000) 5,713,000     96,000 (5,713,000) 170,000                         (170,000)         (100,000) 5,713,000 1,210,000                                              
Loan payable                                                                                                       2,800,000 1,900,000            
Convertible bridge loans issued under private placement, face amount                                                                                 2,600,000       3,000,000           5,500,000 5,600,000              
Interest expense                                                                                                   2,800,000                  
Convertible bridge loans issued under private placement, interest rate                                                                                 8.00%       8.00%                            
Repayment of bridge notes       2,000,000                                                                               100,000                              
Number of warrants cancelled                                                                                             1,388,887                        
Outstanding bridge loan notes                                                                                                     5,500,000                
Fair value of derivative liability                                                                             $ 4,316,000