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Commitments and Contingencies - Additional Information (Detail)
 12 Months Ended 1 Months Ended 1 Months Ended 12 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended
Dec. 31, 2011
USD ($)
Dec. 31, 2010
USD ($)
Dec. 31, 2009
USD ($)
Dec. 31, 2008
USD ($)
Dec. 31, 2011
Amr One Hundred One
USD ($)
Contract
Dec. 31, 2011
Amr One Hundred One
Maximum
USD ($)
Dec. 31, 2011
Amr One Hundred One
Maximum
Initial Payment
USD ($)
Jul. 31, 2011
Chemport
USD ($)
Dec. 31, 2011
Chemport
USD ($)
Oct. 31, 2011
Elan
USD ($)
Dec. 31, 2009
Elan
USD ($)
Dec. 31, 2011
Up On First Marketing Approval of AMR101
USD ($)
Dec. 31, 2011
Net sales up to GBP100 million ($162.0 million at December 31, 2010)
Laxdale Limited
Dec. 31, 2011
Net sales up to GBP100 million ($162.0 million at December 31, 2010)
Laxdale Limited
Maximum
USD ($)
Dec. 31, 2011
Net sales up to GBP100 million ($162.0 million at December 31, 2010)
Laxdale Limited
Maximum
GBP (£)
Dec. 31, 2011
Net sales between GBP100 million ($162.0 million) and GBP500 million ($810.0 million)
Laxdale Limited
Dec. 31, 2011
Net sales between GBP100 million ($162.0 million) and GBP500 million ($810.0 million)
Laxdale Limited
Maximum
USD ($)
Dec. 31, 2011
Net sales between GBP100 million ($162.0 million) and GBP500 million ($810.0 million)
Laxdale Limited
Maximum
GBP (£)
Dec. 31, 2011
Net sales between GBP100 million ($162.0 million) and GBP500 million ($810.0 million)
Laxdale Limited
Minimum
USD ($)
Dec. 31, 2011
Net sales between GBP100 million ($162.0 million) and GBP500 million ($810.0 million)
Laxdale Limited
Minimum
GBP (£)
Dec. 31, 2011
Net sales in excess of GBP500 million
Laxdale Limited
Dec. 31, 2011
Net sales in excess of GBP500 million
Laxdale Limited
Minimum
USD ($)
Dec. 31, 2011
Net sales in excess of GBP500 million
Laxdale Limited
Minimum
GBP (£)
Dec. 31, 2011
First Indication for AMR101
Laxdale Limited
Potential Marketing Approval 1
USD ($)
Dec. 31, 2011
First Indication for AMR101
Laxdale Limited
Potential Marketing Approval 1
GBP (£)
Dec. 31, 2011
First Indication for AMR101
Laxdale Limited
Potential Marketing Approval 2
USD ($)
Dec. 31, 2011
First Indication for AMR101
Laxdale Limited
Potential Marketing Approval 2
GBP (£)
Dec. 31, 2011
First Indication for AMR101
Laxdale Limited
Maximum
USD ($)
Dec. 31, 2011
First Indication for AMR101
Laxdale Limited
Maximum
GBP (£)
Dec. 31, 2011
Further Indication for AMR101
Laxdale Limited
Potential Marketing Approval 1
USD ($)
Dec. 31, 2011
Further Indication for AMR101
Laxdale Limited
Potential Marketing Approval 1
GBP (£)
Dec. 31, 2011
Further Indication for AMR101
Laxdale Limited
Potential Marketing Approval 2
USD ($)
Dec. 31, 2011
Further Indication for AMR101
Laxdale Limited
Potential Marketing Approval 2
GBP (£)
Dec. 31, 2011
Further Indication for AMR101
Laxdale Limited
Maximum
USD ($)
Dec. 31, 2011
Further Indication for AMR101
Laxdale Limited
Maximum
GBP (£)
Dec. 31, 2011
Contract Termination
USD ($)
Dec. 31, 2010
Contract Termination
USD ($)
Dec. 31, 2011
Groton
Nov. 28, 2011
Groton
USD ($)
Year
sqft
Dec. 31, 2011
Dublin
Sep. 30, 2011
Dublin
USD ($)
Year
sqft
Sep. 30, 2011
Dublin
EUR (€)
Dec. 31, 2011
Bedminster
sqft
Dec. 31, 2011
Bedminster
May 31, 2011
Bedminster
USD ($)
sqft
Commitments and Contingencies Disclosure [Line Items]                                                                                          
Office space leased (in square feet)                                                                             4,327   320 320     9,747
Operating lease, term   3 years                                                                                      
Operating lease, term                                                                           3 years              
Operating lease, monthly rent                                                                             $ 8,500   $ 3,500 € 2,700     $ 21,931
Operating lease, expiration date   2011-10-31                                                                           2012-10-31       2014-06-30  
Operating lease, renewal option                                                                             3   1 1      
Additional office space leased (in square feet)                                                                                     2,142    
Operating lease, rental expense   500,000 300,000 300,000                                                                                  
Increase in monthly rent in each of years four, five and six                                                                           3.00%              
Liabilities for exited lease facilities                                                                       100,000 100,000                
One-time non refundable payment due to the supplier                       500,000                                                                  
Maximum penalty if the company is not successful in obtaining NDA approval for AMR101     5,000,000                                                                                    
Number of signed agreements         2                                                                                
Development fees committed           500,000                                                                              
Raw material purchase commitment         1,100,000   5,000,000                                                                            
Minority share equity investment commitment                 3,300,000                                                                        
Cash paid for cost method investment 1,650,000             1,700,000                                                                          
Potential milestone payments                     200,000                                                                    
Milestone payment                   200,000                                                                      
Potential royalty payment as a percentage of net sales                         1.00%     0.50%         0.25%                                                
Net sales for potential royalty payments                           155,000,000 100,000,000   773,000,000 500,000,000 155,000,000 100,000,000   773,000,000 500,000,000                                            
Potential aggregate stock or cash payment                                               $ 11,600,000 £ 7,500,000 $ 11,600,000 £ 7,500,000 $ 23,200,000 £ 15,000,000 $ 7,700,000 £ 5,000,000 $ 7,700,000 £ 5,000,000 $ 15,500,000 £ 10,000,000