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Equity - Additional Information (Detail) (USD $)
 1 Months Ended 12 Months Ended 1 Months Ended 1 Months Ended 12 Months Ended 1 Months Ended
Jan. 31, 2011
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Aug. 31, 2009
Ester Neurosciences Ltd
Oct. 31, 2009
Bridge Loan
Oct. 31, 2009
October 2009 Private Placement
Point
Oct. 31, 2009
October 2009 Private Placement
Bridge Loan
Point
Oct. 16, 2009
October 2009 Private Placement
Bridge Loan
Dec. 31, 2011
October 2009 Private Placement
Warrants Issued October 2009
Dec. 31, 2010
October 2009 Private Placement
Warrants Issued October 2009
Oct. 16, 2010
October 2009 Private Placement
Warrants Issued October 2009
American Depositary Share
Oct. 16, 2009
October 2009 Private Placement
Warrants Issued October 2009
American Depositary Share
Oct. 16, 2009
October 2009 Private Placement
Warrants Issued October 2009
Bridge Loan
Oct. 31, 2009
Proseed Capital Holdings
Stockholders Equity Note [Line Items]                              
Common stock issued, shares 13,800,000       1,315,789   66,400,000 4,000,000             39,473
Number of shares that each ADS represents             1 1              
Common stock issued under private placement, value   $ 98,654,000   $ 62,253,000 $ 1,800,000   $ 70,000,000                
Common stock issued, price per share $ 7.60           $ 1.0                
Gross proceed from common shares issued 104,900,000                            
Proceed from common shares issued 98,654,000 98,654,000   62,253,000                      
Shares issued, exercise of stock options   2,273,221                          
Gross proceeds from exercise of stock options   5,200,000                          
Net proceeds from exercise of stock options   5,094,000 3,642,000                        
Shares issued, exercise of warrants   12,888,369                          
Gross proceeds from exercise of warrants   19,000,000                          
Net proceeds from exercise of warrants   18,702,000 8,904,000             18,100,000 8,000,000        
Common stock issued under private placement, net proceeds             62,253,000                
Bridge notes converted in conjunction with the private placement, amount               3,600,000              
Bridge notes converted in conjunction with the private placement, shares of common stock issued               3,999,996              
Warrant term                       5 years 5 years 5 years  
Warrants issued, number of shares called by the warrant               1,999,996 1,999,996     0.5 0.5 0.5  
Exercise price of the warrants   1.48           1.50 1.50     1.50 1.50 1.50  
Outstanding bridge loan notes           $ 5,500,000