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CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $)
In Thousands, unless otherwise specified
 12 Months Ended
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
CASH FLOWS FROM OPERATING ACTIVITIES:      
Net loss $ (69,126) $ (249,589) $ (30,606)
Adjustments to reconcile loss to net cash used in operating activities:      
Depreciation and amortization 76 63 583
Gain on sale of intellectual property     (700)
Stock-based compensation 9,294 5,207 2,859
Excess tax benefit from stock-based awards (4,199) (543)  
Non-cash interest     2,803
Loss (gain) on changes in fair value of derivative liability 22,669 205,153 (5,137)
Deferred income taxes (2,493) (1,691) (689)
Change in lease liability (21) (583) (290)
Shares issued for services 71 12  
Changes in assets and liabilities:      
Other current assets (774) 912 (68)
Other non-current assets (591)    
Accounts payable and other current liabilities 5,751 1,476 897
Net cash used in operating activities (39,439) (33,870) (28,406)
CASH FLOWS FROM INVESTING ACTIVITIES:      
Purchases of equipment (398) (23) (116)
Purchase of long term investment (1,650)    
Sale of lorazepam     700
Net cash (used in) provided by investing activities (2,048) (23) 584
CASH FLOWS FROM FINANCING ACTIVITIES:      
Proceeds from issuance of common stock, net of transaction costs 98,654   62,253
Proceeds from exercise of stock options, net of transaction costs 5,094 3,642  
Proceeds from exercise of warrants, net of transaction costs 18,702 8,904  
Proceeds on issuance of convertible debt     5,600
Repayment of convertible debt     (2,000)
Excess tax benefit from stock-based awards 4,199 543  
Repayment of finance leases (2) (12) (12)
Net cash provided by financing activities 126,647 13,077 65,841
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS 85,160 (20,816) 38,019
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD 31,442 52,258 14,239
CASH AND CASH EQUIVALENTS, END OF PERIOD 116,602 31,442 52,258
Cash paid during the year for:      
Interest   2 125
Income taxes 761 230  
Supplemental disclosure of non-cash items:      
Reclass of warrant liability to additional paid-in capital 129,517 22,317 5,328
Reclass of additional paid-in capital to warrant liability     47,105
Conversion of bridge loans     3,600
Ester
      
Adjustments to reconcile loss to net cash used in operating activities:      
Stock-based compensation     902
Supplemental disclosure of non-cash items:      
Issuance of Shares     1,842
Warrant
      
Adjustments to reconcile loss to net cash used in operating activities:      
Stock-based compensation (96) 5,713 1,040
Proseed Capital Holdings
      
Supplemental disclosure of non-cash items:      
Issuance of Shares     $ 51