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Related Party Transactions - Additional Information (Detail)
 1 Months Ended 1 Months Ended 12 Months Ended 12 Months Ended 1 Months Ended 3 Months Ended 12 Months Ended 1 Months Ended 1 Months Ended 12 Months Ended
Jan. 31, 2011
Dec. 31, 2011
Oct. 31, 2009
Mr Thomas Lynch
Dec. 31, 2009
Mr Thomas Lynch
USD ($)
Oct. 16, 2009
Mr Thomas Lynch
USD ($)
Dec. 31, 2009
Elan Pharma International Ltd
USD ($)
Jan. 31, 2009
Dalriada Ltd Agreement
USD ($)
Mar. 31, 2007
Dalriada Ltd Agreement
GBP (£)
Dec. 31, 2007
Dalriada Ltd Agreement
USD ($)
Dec. 31, 2007
Dalriada Ltd Agreement
GBP (£)
Jan. 31, 2009
Dalriada Ltd Agreement
EUR (€)
Oct. 31, 2009
Mr Alan Cooke
USD ($)
Oct. 31, 2009
Mr Alan Cooke
EUR (€)
Oct. 16, 2009
Mr Alan Cooke
USD ($)
Dec. 31, 2011
October 2009 Private Placement
Warrant
USD ($)
Oct. 31, 2009
October 2009 Private Placement
American Depository Share
USD ($)
Point
Oct. 31, 2009
October 2009 Private Placement
American Depository Share
Abingworth LLP
USD ($)
Oct. 31, 2009
October 2009 Private Placement
American Depository Share
Orbimed Advisors LLC
USD ($)
Oct. 31, 2009
October 2009 Private Placement
American Depository Share
Sofinnova Venture Partners VII, LP
USD ($)
Oct. 31, 2009
October 2009 Private Placement
American Depository Share
Fountain Healthcare Partners Fund 1, LP
USD ($)
Dec. 31, 2011
June 2009 Convertible Bridge Loans
Dr John Climax
USD ($)
Dec. 31, 2011
June 2009 Convertible Bridge Loans
Mr Thomas Lynch
USD ($)
Dec. 31, 2011
July 2009 Convertible Bridge Loans
Dr John Climax
USD ($)
Dec. 31, 2011
July 2009 Convertible Bridge Loans
Mr Thomas Lynch
Dec. 31, 2011
July 2009 Convertible Bridge Loans
Mr Thomas Lynch
Exercise Price 1
Dec. 31, 2011
July 2009 Convertible Bridge Loans
Mr Thomas Lynch
Exercise Price 2
Related Party Transaction [Line Items]                                                    
Purchase of ADSs (in the form of common stock) by directors in private placement                               $ 36,000,000 $ 17,000,000 $ 7,000,000 $ 7,000,000 $ 5,000,000            
Number of ADS that can be purchased for each warrant received                               0.5                    
Termination payment                       607,500 375,000                          
Warrant derivative liability                             123,100,000                      
Warrants issued     500,000                 247,050 247,050                     277,776 138,888 138,888
Financing amount       70,000,000                                            
Warrant derivative liability, fair value         669,000                 331,000 102,000,000                      
Exercise price of warrants   1.48                       1.50                     1.00 1.50
Warrants issued, exercisable period                       5 years 5 years                     5 years    
Loans purchased by director                                         2,000,000 300,000 1,000,000      
Proceed from sale of the development and license agreement           700,000                                        
Annual Payment under agreement for consultancy services             400,000 240,000     300,000                              
Additional performance related payment               195,000                                    
Payment under service agreement             $ 100,000   $ 121,500 £ 75,000                                
Shares issued 13,800,000                                         277,777