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Commitments and Contingencies - Additional Information (Detail)
 9 Months Ended 9 Months Ended 1 Months Ended 3 Months Ended
Sep. 30, 2012
USD ($)
Sep. 30, 2011
USD ($)
Dec. 31, 2011
USD ($)
Sep. 30, 2012
Amr One Hundred One
USD ($)
Contract
Sep. 30, 2012
Amr One Hundred One
Maximum
USD ($)
Sep. 30, 2012
Amr One Hundred One
Maximum
Initial Payment
USD ($)
Sep. 30, 2012
Fourth API supplier
Maximum
USD ($)
Jul. 31, 2012
Chemport
USD ($)
May 31, 2012
Chemport
USD ($)
Jul. 31, 2011
Chemport
USD ($)
Sep. 30, 2012
Chemport
USD ($)
Sep. 30, 2012
Chemport
Anticipated investment before the end of 2012
USD ($)
Dec. 31, 2009
Elan
USD ($)
Sep. 30, 2012
Laxdale Limited
USD ($)
Jul. 26, 2012
Laxdale Limited
USD ($)
Sep. 30, 2012
Up On First Marketing Approval of AMR101
USD ($)
Sep. 30, 2012
Net sales up to GBP100 million ($156 million at September 30, 2012)
Laxdale Limited
Sep. 30, 2012
Net sales up to GBP100 million ($156 million at September 30, 2012)
Laxdale Limited
Maximum
USD ($)
Sep. 30, 2012
Net sales up to GBP100 million ($156 million at September 30, 2012)
Laxdale Limited
Maximum
GBP (£)
Sep. 30, 2012
Net sales between GBP100 million ($156.0 million) and GBP500 million ($780.7 million)
Laxdale Limited
Sep. 30, 2012
Net sales between GBP100 million ($156.0 million) and GBP500 million ($780.7 million)
Laxdale Limited
Maximum
USD ($)
Sep. 30, 2012
Net sales between GBP100 million ($156.0 million) and GBP500 million ($780.7 million)
Laxdale Limited
Maximum
GBP (£)
Sep. 30, 2012
Net sales between GBP100 million ($156.0 million) and GBP500 million ($780.7 million)
Laxdale Limited
Minimum
USD ($)
Sep. 30, 2012
Net sales between GBP100 million ($156.0 million) and GBP500 million ($780.7 million)
Laxdale Limited
Minimum
GBP (£)
Sep. 30, 2012
Net sales in excess of GBP500 million
Laxdale Limited
Sep. 30, 2012
Net sales in excess of GBP500 million
Laxdale Limited
Minimum
USD ($)
Sep. 30, 2012
Net sales in excess of GBP500 million
Laxdale Limited
Minimum
GBP (£)
Sep. 30, 2012
First Indication for AMR101
Laxdale Limited
Potential Marketing Approval 1
USD ($)
Sep. 30, 2012
First Indication for AMR101
Laxdale Limited
Potential Marketing Approval 1
GBP (£)
Sep. 30, 2012
First Indication for AMR101
Laxdale Limited
Potential Marketing Approval 2
USD ($)
Sep. 30, 2012
First Indication for AMR101
Laxdale Limited
Potential Marketing Approval 2
GBP (£)
Sep. 30, 2012
First Indication for AMR101
Laxdale Limited
Maximum
USD ($)
Sep. 30, 2012
First Indication for AMR101
Laxdale Limited
Maximum
GBP (£)
Sep. 30, 2012
Further Indication for AMR101
Laxdale Limited
Potential Marketing Approval 1
USD ($)
Sep. 30, 2012
Further Indication for AMR101
Laxdale Limited
Potential Marketing Approval 1
GBP (£)
Sep. 30, 2012
Further Indication for AMR101
Laxdale Limited
Potential Marketing Approval 2
USD ($)
Sep. 30, 2012
Further Indication for AMR101
Laxdale Limited
Potential Marketing Approval 2
GBP (£)
Sep. 30, 2012
Further Indication for AMR101
Laxdale Limited
Maximum
USD ($)
Sep. 30, 2012
Further Indication for AMR101
Laxdale Limited
Maximum
GBP (£)
Commitments and Contingencies Disclosure [Line Items]                                                                              
One-time non-refundable payment due to the supplier                               $ 500,000                                              
Minimum purchase obligations 27,700,000                                                                            
Number of signed agreements       2                                                                      
Development fees committed         500,000   2,300,000                                                                
Raw material purchase commitment       1,100,000   5,000,000 15,000,000                                                                
Payment made under the agreements       3,400,000                                                                      
Minority share equity investment commitment                     3,300,000 400,000                                                      
Cash paid for cost method investment 1,238,000 1,650,000           400,000 800,000 1,700,000                                                          
Potential milestone payments                         200,000                                                    
Potential royalty payment as a percentage of net sales                                 1.00%     0.50%         0.25%                            
Net sales for potential royalty payments                                   161,600,000 100,000,000   808,200,000 500,000,000 161,600,000 100,000,000   808,200,000 500,000,000                        
Potential aggregate stock or cash payment                                                       12,100,000 7,500,000 12,100,000 7,500,000 24,200,000 15,000,000 8,100,000 5,000,000 8,100,000 5,000,000 16,200,000 10,000,000
Milestone payment capitalized as other long term asset 15,672,000   2,241,000                       11,600,000                                                
Milestone payment, amortization expense                           100,000                                                  
Unrealized exchange rate losses on the liability                           500,000                                                  
Liability for uncertain tax positions $ 700,000