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CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Share data, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
Revenues |  |  |
Operating Expenses: |  |  |
Research and development | 58,956 | 21,602 | 28,014
Marketing, general and administrative | 57,794 | 22,559 | 17,087
Total operating expenses | 116,750 | 44,161 | 45,101
Operating loss | (116,750) | (44,161) | (45,101)
Loss on change in fair value of derivative liabilities | (35,344) | (22,669) | (205,153)
Interest expense | (18,091) | (1) | (19)
Interest income | 544 | 231 | 53
Other (expense) income, net | (427) | (10) | 130
Loss from operations before taxes | (170,068) | (66,610) | (250,090)
(Provision for) benefit from income taxes | (9,116) | (2,516) | 501
Net loss | $ (179,184) | $ (69,126) | $ (249,589)
Loss per basic and diluted share: | $ (1.24) | $ (0.53) | $ (2.49)
Weighted average shares outstanding: |  |  |
Basic and diluted | 144,017 | 130,247 | 100,239

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