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Stock Incentive Plans and Stock Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2012
Stock Option Activity | The following table summarizes all stock option activity for the year ended December 31, 2012:
|  | Number of Shares |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term |  |  | Aggregate Intrinsic Value |
|  | (in thousands, except for per share amounts) |
Outstanding January 1, 2012 |  |  | 11,871 |  |  | $ | 5.33 |  |  |  |  |  |  |  |  |
Granted |  |  | 2,705 |  |  |  | 10.49 |  |  |  |  |  |  |  |  |
Cancelled/Expired |  |  | (304 | ) |  |  | 13.09 |  |  |  |  |  |  |  |  |
Exercised |  |  | (3,380 | ) |  |  | 2.44 |  |  |  |  |  |  |  |  |
Outstanding, December 31, 2012 |  |  | 10,892 |  |  | $ | 7.29 |  |  |  | 8.3 years |  |  | $ | 26,337 |
Exercisable, December 31, 2012 |  |  | 3,857 |  |  | $ | 5.23 |  |  |  | 7.8 years |  |  | $ | 15,234 |
Vested and Expected to Vest, December 31, 2012 |  |  | 10,632 |  |  | $ | 7.26 |  |  |  | 8.2 years |  |  | $ | 25,927 |
Available for future grant at December 31, 2012 |  |  | 7,864 |  |  |  |  |  |  |  |  |  |  |  |  |
Assumptions Used to Estimate Fair Value of Share-Based Payment Awards | For 2012, 2011 and 2010, the Company used the following assumptions to estimate the fair value of share-based payment awards:
|  | 2012 |  | 2011 |  | 2010
Risk free interest rate |  | 0.81% - 1.39% |  | 2.03% - 2.56% |  | 1.5% - 3.1%
Expected dividend yield |  | 0.00% |  | 0.00% |  | 0.00%
Expected option life (years) |  | 6.25 |  | 6.25 |  | 5.75 - 6.25
Expected volatility |  | 109% - 111% |  | 105% - 112% |  | 105% - 110%
Restricted stock unit activity | The following table presents the restricted stock unit activity for the year ended December 31, 2012.
|  | Shares |  |  | Weighted Average Grant Date Fair Value |
|  | (in thousands) |  |  |  |
Outstanding January 1, 2012: |  |  |  |  |  |  |  |
Granted |  |  | 584 |  |  | $ | 8.86 |
Vested |  |  | (97 | ) |  |  | 8.86 |
Forfeited |  |  | (22 | ) |  |  | 8.86 |
Outstanding—as of December 31, 2012 |  |  | 465 |  |  |  | 8.86 |
Stock-Based Compensation Expense Related to Option Awards | The following table presents the stock-based compensation expense related to stock based awards for the period ended December 31:
|  | 2012 |  |  | 2011 |  |  | 2010 |
|  | (in thousands) |
Research and development |  | $ | 3,700 |  |  | $ | 1,464 |  |  | $ | 1,534 |
General and administrative |  |  | 14,375 |  |  |  | 7,830 |  |  |  | 3,673 |
Stock-based compensation expense |  | $ | 18,075 |  |  | $ | 9,294 |  |  | $ | 5,207 |

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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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