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Commitments and Contingencies - Additional Information (Detail) | 12 Months Ended | 1 Months Ended | 12 Months Ended |  | 12 Months Ended |  | 12 Months Ended |  |  | 12 Months Ended |  | 12 Months Ended |  | 1 Months Ended | 12 Months Ended |
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Dec. 31, 2012 USD ($) | Dec. 31, 2011 USD ($) | Dec. 31, 2010 USD ($) | Dec. 31, 2012 Amr One Hundred One USD ($) Contract | Dec. 31, 2012 Amr One Hundred One Maximum USD ($) | Dec. 31, 2012 Amr One Hundred One Maximum Initial Payment USD ($) | Dec. 31, 2012 Fourth API supplier Maximum USD ($) | Jul. 31, 2011 Chemport USD ($) | Dec. 31, 2012 Chemport USD ($) | Dec. 31, 2012 Chemport Anticipated investment before the end of 2012 USD ($) | Dec. 31, 2012 Laxdale Limited USD ($) | Jul. 26, 2012 Laxdale Limited USD ($) | Dec. 31, 2012 BASF USD ($) | Dec. 31, 2012 Slanhmor USD ($) | Dec. 31, 2012 Up On First Marketing Approval of AMR101 USD ($) | Dec. 31, 2012 First Indication for AMR101 Laxdale Limited Potential Marketing Approval 1 USD ($) | Dec. 31, 2012 First Indication for AMR101 Laxdale Limited Potential Marketing Approval 1 GBP (£) | Dec. 31, 2012 First Indication for AMR101 Laxdale Limited Potential Marketing Approval 2 USD ($) | Dec. 31, 2012 First Indication for AMR101 Laxdale Limited Potential Marketing Approval 2 GBP (£) | Dec. 31, 2012 Further Indication for AMR101 Laxdale Limited Potential Marketing Approval 1 USD ($) | Dec. 31, 2012 Further Indication for AMR101 Laxdale Limited Potential Marketing Approval 1 GBP (£) | Dec. 31, 2012 Further Indication for AMR101 Laxdale Limited Potential Marketing Approval 2 USD ($) | Dec. 31, 2012 Further Indication for AMR101 Laxdale Limited Potential Marketing Approval 2 GBP (£) | Dec. 31, 2012 Further Indication for AMR101 Laxdale Limited Maximum USD ($) | Dec. 31, 2012 Further Indication for AMR101 Laxdale Limited Maximum GBP (£) | Dec. 31, 2012 Contract Termination USD ($) | Dec. 31, 2011 Contract Termination USD ($) | Dec. 31, 2012 Groton | Nov. 28, 2011 Groton USD ($) sqft Y | Dec. 31, 2012 Dublin | Sep. 30, 2011 Dublin USD ($) sqft Y | Sep. 30, 2011 Dublin EUR (€) | Dec. 31, 2012 Bedminster sqft | Dec. 31, 2011 Bedminster sqft | Dec. 31, 2012 Bedminster | May 31, 2011 Bedminster USD ($) sqft
Commitments and Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Office space leased (in square feet) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,327 |  | 320 | 320 |  |  |  | 9,747
Operating lease, term |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |  |
Operating lease, monthly rent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 8,500 |  | $ 3,500 | € 2,700 |  |  |  | $ 21,931
Operating lease, renewal option |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 |  | 1 | 1 |  |  |  |
Increase in monthly rent in each of years four, five and six |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3.00% |  |  |  |  |  |  |  |
Operating lease, expiration date |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Oct. 31, 2013 |  |  |  |  | Jun. 30, 2014 |
Additional office space leased (in square feet) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,601 | 2,142 |  |
Operating lease, rental expense | 600,000 | 500,000 | 300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Liabilities for exited lease facilities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20,000 | 100,000 |  |  |  |  |  |  |  |  |
One-time non-refundable payment due to the supplier |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Minimum purchase obligations | 9,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of signed agreements |  |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development fees committed |  |  |  |  | 500,000 |  | 2,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Raw material purchase commitment |  |  |  | 1,100,000 |  | 5,000,000 | 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment made under the agreements |  |  |  |  |  |  |  |  | 1,000,000 |  |  |  | 200,000 | 1,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Advance payment made under the agreements | 3,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Minority share equity investment commitment |  |  |  |  |  |  |  |  | 3,300,000 | 1,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash paid for cost method investment | 1,650,000 | 1,650,000 |  |  |  |  |  | 1,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential aggregate stock or cash payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 12,100,000 | 7,500,000 | 12,100,000 | 7,500,000 | 8,100,000 | 5,000,000 | 8,100,000 | 5,000,000 | 16,200,000 | 10,000,000 |  |  |  |  |  |  |  |  |  |  |
Accrued liability payable |  |  |  |  |  |  |  |  |  |  |  | 11,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization expense |  |  |  |  |  |  |  |  |  |  | 300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash paid for settlement liability |  |  |  |  |  |  |  |  |  |  | 12,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Currency exchange loss |  |  |  |  |  |  |  |  |  |  | $ 500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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