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Stock Based Compensation Expense (Detail) (USD $) In Thousands, unless otherwise specified | 12 Months Ended
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Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Stock-based compensation expense | $ 18,075 | $ 9,294 | $ 5,207
Stock Based Compensation Expense |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Stock-based compensation expense | 18,075 | 9,294 | 5,207
Research and Development |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Stock-based compensation expense | 3,700 | 1,464 | 1,534
General and Administrative |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Stock-based compensation expense | $ 14,375 | $ 7,830 | $ 3,673

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 28 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3602-108585 + Details
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