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CONSOLIDATED STATEMENTS OF OPERATIONS (USD $)
In Thousands, except Share data, unless otherwise specified
 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Revenues         
Operating Expenses:      
Research and development 58,956 21,602 28,014
Marketing, general and administrative 57,794 22,559 17,087
Total operating expenses 116,750 44,161 45,101
Operating loss (116,750) (44,161) (45,101)
Loss on change in fair value of derivative liabilities (35,344) (22,669) (205,153)
Interest expense (18,091) (1) (19)
Interest income 544 231 53
Other (expense) income, net (427) (10) 130
Loss from operations before taxes (170,068) (66,610) (250,090)
(Provision for) benefit from income taxes (9,116) (2,516) 501
Net loss $ (179,184) $ (69,126) $ (249,589)
Loss per basic and diluted share: $ (1.24) $ (0.53) $ (2.49)
Weighted average shares outstanding:      
Basic and diluted 144,017 130,247 100,239