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Debt - Additional Information (Detail) (USD $)
 12 Months Ended 1 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Jan. 31, 2012
Jan. 31, 2012
Convertible Debt
Dec. 31, 2012
Convertible Debt
Dec. 31, 2012
Convertible Debt
American Depository Shares
Jul. 31, 2012
3.5% exchangeable senior notes due 2032
Finance
Dec. 31, 2012
Cash
Dec. 31, 2012
Non Cash
Dec. 31, 2012
Proceeds
Convertible Debt
Dec. 31, 2012
Debt Offering
Convertible Debt
Dec. 31, 2012
Biopharma
Dec. 31, 2012
Biopharma
November 2013 for the fiscal quarter ended September 30, 2013
Dec. 31, 2012
Biopharma
Per quarter in each of the next four quarters
Dec. 31, 2012
Biopharma
Per quarter in each of the next four quarters
Dec. 31, 2012
Biopharma
Per quarter in each of the next four quarters
Dec. 31, 2012
Biopharma
Final payment
Debt Disclosure [Line Items]                                    
Amount received at the closing of the agreement                         $ 100,000,000          
Maximum repayment of future revenue and receivables                         150,000,000          
Future minimum repayment under agreement                           2,500,000 8,000,000 10,000,000 15,000,000 13,000,000
Agreement expiration date                         Dec. 31, 2013          
Change of control obligation                         140,000,000          
Fair value of Embedded derivative liability 14,600,000                                  
Gain on change in fair value of derivative liability 20,000                                  
Interest expense 18,091,000 1,000 19,000           100,000 20,000                
Convertible senior notes, principal amount         150,000,000                          
Convertible senior notes, stated interest rate         3.50%                          
Convertible senior notes, due date         2032                          
Convertible senior notes, net proceeds 144,316,000       144,300,000                          
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes             113.4752                      
Convertible senior notes, total ADS into which the debt is exchangeable             17,021,280                      
Convertible senior notes, payment start date         Jul. 15, 2012                          
Convertible senior notes, maturity date         Jan. 15, 2032                          
Value of shares in excess of principal amount of Notes based on closing price 12,300,000                                  
Additional interest rate on notes per annum           0.50%                        
Convertible senior notes, repurchase price at option of the issuer       100.00%                            
Proceeds allocated to conversion option 99,730,000         23,800,000                        
Fair value of the liability component         150,000,000 126,200,000                        
Note, estimated remaining life           24 months                        
Effective interest rate           14.50%                        
Unamortized debt discount           2,600,000         13,100,000              
Debt discount amortization period           24 months                        
Convertible senior notes, carrying amount net of unamortized discount           134,300,000                        
Convertible senior notes, interest expense           17,900,000                        
Interest expense, contractual coupon interest accrual           10,700,000                        
Interest expense, amortization of discount           5,100,000           2,100,000            
Accrued interest on convertible note 2,520,000         2,400,000                        
Interest payment on notes $ 2,713,000   $ 2,000         $ 2,700,000