XML 79 R49.htm IDEA: XBRL DOCUMENT v2.4.0.6
Commitments and Contingencies - Additional Information (Detail)
 12 Months Ended 1 Months Ended 12 Months Ended 12 Months Ended 12 Months Ended 12 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended
Dec. 31, 2012
USD ($)
Dec. 31, 2011
USD ($)
Dec. 31, 2010
USD ($)
Dec. 31, 2012
Amr One Hundred One
USD ($)
Contract
Dec. 31, 2012
Amr One Hundred One
Maximum
USD ($)
Dec. 31, 2012
Amr One Hundred One
Maximum
Initial Payment
USD ($)
Dec. 31, 2012
Fourth API supplier
Maximum
USD ($)
Jul. 31, 2011
Chemport
USD ($)
Dec. 31, 2012
Chemport
USD ($)
Dec. 31, 2012
Chemport
Anticipated investment before the end of 2012
USD ($)
Dec. 31, 2012
Laxdale Limited
USD ($)
Jul. 26, 2012
Laxdale Limited
USD ($)
Dec. 31, 2012
BASF
USD ($)
Dec. 31, 2012
Slanhmor
USD ($)
Dec. 31, 2012
Up On First Marketing Approval of AMR101
USD ($)
Dec. 31, 2012
First Indication for AMR101
Laxdale Limited
Potential Marketing Approval 1
USD ($)
Dec. 31, 2012
First Indication for AMR101
Laxdale Limited
Potential Marketing Approval 1
GBP (£)
Dec. 31, 2012
First Indication for AMR101
Laxdale Limited
Potential Marketing Approval 2
USD ($)
Dec. 31, 2012
First Indication for AMR101
Laxdale Limited
Potential Marketing Approval 2
GBP (£)
Dec. 31, 2012
Further Indication for AMR101
Laxdale Limited
Potential Marketing Approval 1
USD ($)
Dec. 31, 2012
Further Indication for AMR101
Laxdale Limited
Potential Marketing Approval 1
GBP (£)
Dec. 31, 2012
Further Indication for AMR101
Laxdale Limited
Potential Marketing Approval 2
USD ($)
Dec. 31, 2012
Further Indication for AMR101
Laxdale Limited
Potential Marketing Approval 2
GBP (£)
Dec. 31, 2012
Further Indication for AMR101
Laxdale Limited
Maximum
USD ($)
Dec. 31, 2012
Further Indication for AMR101
Laxdale Limited
Maximum
GBP (£)
Dec. 31, 2012
Contract Termination
USD ($)
Dec. 31, 2011
Contract Termination
USD ($)
Dec. 31, 2012
Groton
Nov. 28, 2011
Groton
USD ($)
sqft
Y
Dec. 31, 2012
Dublin
Sep. 30, 2011
Dublin
USD ($)
sqft
Y
Sep. 30, 2011
Dublin
EUR (€)
Dec. 31, 2012
Bedminster
sqft
Dec. 31, 2011
Bedminster
sqft
Dec. 31, 2012
Bedminster
May 31, 2011
Bedminster
USD ($)
sqft
Commitments and Contingencies Disclosure [Line Items]                                                                        
Office space leased (in square feet)                                                         4,327   320 320       9,747
Operating lease, term                                                       3 years                
Operating lease, monthly rent                                                         $ 8,500   $ 3,500 € 2,700       $ 21,931
Operating lease, renewal option                                                         3   1 1        
Increase in monthly rent in each of years four, five and six                                                       3.00%                
Operating lease, expiration date                                                           Oct. 31, 2013         Jun. 30, 2014  
Additional office space leased (in square feet)                                                                 2,601 2,142    
Operating lease, rental expense 600,000 500,000 300,000                                                                  
Liabilities for exited lease facilities                                                   20,000 100,000                  
One-time non-refundable payment due to the supplier                             500,000                                          
Minimum purchase obligations 9,900,000                                                                      
Number of signed agreements       2                                                                
Development fees committed         500,000   2,300,000                                                          
Raw material purchase commitment       1,100,000   5,000,000 15,000,000                                                          
Payment made under the agreements                 1,000,000       200,000 1,600,000                                            
Advance payment made under the agreements 3,000,000                                                                      
Minority share equity investment commitment                 3,300,000 1,600,000                                                    
Cash paid for cost method investment 1,650,000 1,650,000           1,700,000                                                        
Potential aggregate stock or cash payment                               12,100,000 7,500,000 12,100,000 7,500,000 8,100,000 5,000,000 8,100,000 5,000,000 16,200,000 10,000,000                      
Accrued liability payable                       11,600,000                                                
Amortization expense                     300,000                                                  
Cash paid for settlement liability                     12,100,000                                                  
Currency exchange loss                     $ 500,000