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Related Party Transactions - Additional Information (Detail) (October 2009 Private Placement, USD $) In Millions, unless otherwise specified		1 Months Ended
	Dec. 31, 2012 Warrant	Oct. 31, 2009 American Depository Share Point	Oct. 31, 2009 American Depository Share Abingworth LLP	Oct. 31, 2009 American Depository Share Orbimed Advisors LLC	Oct. 31, 2009 American Depository Share Sofinnova Venture Partners VII, LP	Oct. 31, 2009 American Depository Share Fountain Healthcare Partners Fund 1, LP
Related Party Transaction [Line Items]
Purchase of ADSs (in the form of common stock) by directors in private placement		$ 36.0	$ 17.0	$ 7.0	$ 7.0	$ 5.0
Number of ADS that can be purchased for each warrant received		0.5
Warrant derivative liability	54.9
Warrant derivative liability, fair value	$ 35.5

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Fair value of derivative liability, presented on a gross basis even when the derivative instrument is subject to master netting arrangements and qualifies for net presentation in the statement of financial position.

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