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Debt - Additional Information (Detail) (USD $) | 3 Months Ended |  |  | 1 Months Ended | 3 Months Ended |  | 3 Months Ended | 1 Months Ended | 3 Months Ended |  | 3 Months Ended | 12 Months Ended |
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Mar. 31, 2013 | Mar. 31, 2012 | Dec. 31, 2012 | Jan. 31, 2012 | Jan. 31, 2012 Convertible Debt | Mar. 31, 2013 Convertible Debt | Dec. 31, 2012 Convertible Debt | Mar. 31, 2013 Convertible Debt American Depository Shares | Jan. 31, 2013 3.5% exchangeable senior notes due 2032 Finance | Mar. 31, 2013 Cash | Mar. 31, 2013 Non Cash | Mar. 31, 2013 Proceeds Convertible Debt | Mar. 31, 2013 Debt Offering Convertible Debt | Dec. 31, 2012 Biopharma | Dec. 31, 2012 Biopharma November 2013 for the fiscal quarter ended September 30, 2013 | Dec. 31, 2012 Biopharma Per quarter in each of the next four quarters | Dec. 31, 2012 Biopharma Per quarter in each of the next four quarters | Dec. 31, 2012 Biopharma Per quarter in each of the next four quarters | Dec. 31, 2012 Biopharma Final payment
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount received at the closing of the agreement |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 100,000,000 |  |  |  |  |
Maximum repayment of future revenue and receivables |  |  |  |  |  |  |  |  |  |  |  |  |  | 150,000,000 |  |  |  |  |
Future minimum repayment under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,500,000 | 8,000,000 | 10,000,000 | 15,000,000 | 13,000,000
Agreement expiration date |  |  |  |  |  |  |  |  |  |  |  |  |  | Dec. 31, 2013 |  |  |  |  |
Change of control obligation |  |  |  |  |  |  |  |  |  |  |  |  |  | 140,000,000 |  |  |  |  |
Fair value of Embedded derivative liability | 14,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of derivative liability | 15,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gain on change in fair value of derivative liability | 1,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense |  |  |  |  |  |  |  |  |  | 3,400,000 | 700,000 |  |  |  |  |  |  |  |
Convertible senior notes, interest expense | 4,100,000 |  |  |  |  | 4,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, principal amount |  |  |  |  | 150,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, stated interest rate |  |  |  |  | 3.50% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, due date |  |  |  |  | 2032 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, net proceeds |  | 144,316,000 |  |  | 144,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  |  |  |  |  |  |  | 113.4752 |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, total ADS into which the debt is exchangeable |  |  |  |  |  |  |  | 17,021,280 |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, payment start date |  |  |  |  | Jul. 15, 2012 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, maturity date |  |  |  |  | Jan. 15, 2032 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Value of shares in excess of principal amount of Notes based on closing price | 23,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional interest rate on notes per annum |  |  |  |  |  |  | 0.50% |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, repurchase price at option of the issuer |  |  |  | 100.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds allocated to conversion option |  |  |  |  |  | 23,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of the liability component |  |  |  |  | 150,000,000 | 126,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Note, estimated remaining life |  |  |  |  |  | 24 months |  |  |  |  |  |  |  |  |  |  |  |  |
Effective interest rate |  |  |  |  |  | 14.50% |  |  |  |  |  |  |  |  |  |  |  |  |
Unamortized debt discount |  |  |  |  |  | 2,100,000 |  |  |  |  |  | 10,200,000 |  |  |  |  |  |  |
Debt discount amortization period |  |  |  |  |  | 24 months |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, carrying amount net of unamortized discount |  |  |  |  |  | 137,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense, contractual coupon interest accrual |  |  |  |  |  | 1,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense, amortization of discount |  |  |  |  |  | 2,900,000 |  |  |  |  |  |  | 600,000 |  |  |  |  |  |
Accrued interest on convertible note | 4,646,000 |  | 2,520,000 |  |  | 1,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Interest payment on notes | $ 2,625,000 |  |  |  |  |  |  |  | $ 2,600,000 |  |  |  |  |  |  |  |  |  |

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- Definition The amount of cash paid for interest during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4297-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 29 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 25 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3536-108585 + Details
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