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Debt - Additional Information (Detail) (USD $)
 3 Months Ended 1 Months Ended 3 Months Ended 3 Months Ended 1 Months Ended 3 Months Ended 3 Months Ended 12 Months Ended
Mar. 31, 2013
Mar. 31, 2012
Dec. 31, 2012
Jan. 31, 2012
Jan. 31, 2012
Convertible Debt
Mar. 31, 2013
Convertible Debt
Dec. 31, 2012
Convertible Debt
Mar. 31, 2013
Convertible Debt
American Depository Shares
Jan. 31, 2013
3.5% exchangeable senior notes due 2032
Finance
Mar. 31, 2013
Cash
Mar. 31, 2013
Non Cash
Mar. 31, 2013
Proceeds
Convertible Debt
Mar. 31, 2013
Debt Offering
Convertible Debt
Dec. 31, 2012
Biopharma
Dec. 31, 2012
Biopharma
November 2013 for the fiscal quarter ended September 30, 2013
Dec. 31, 2012
Biopharma
Per quarter in each of the next four quarters
Dec. 31, 2012
Biopharma
Per quarter in each of the next four quarters
Dec. 31, 2012
Biopharma
Per quarter in each of the next four quarters
Dec. 31, 2012
Biopharma
Final payment
Debt Disclosure [Line Items]                                      
Amount received at the closing of the agreement                           $ 100,000,000          
Maximum repayment of future revenue and receivables                           150,000,000          
Future minimum repayment under agreement                             2,500,000 8,000,000 10,000,000 15,000,000 13,000,000
Agreement expiration date                           Dec. 31, 2013          
Change of control obligation                           140,000,000          
Fair value of Embedded derivative liability 14,600,000                                    
Fair value of derivative liability 15,600,000                                    
Gain on change in fair value of derivative liability 1,000,000                                    
Interest expense                   3,400,000 700,000                
Convertible senior notes, interest expense 4,100,000         4,800,000                          
Convertible senior notes, principal amount         150,000,000                            
Convertible senior notes, stated interest rate         3.50%                            
Convertible senior notes, due date         2032                            
Convertible senior notes, net proceeds   144,316,000     144,300,000                            
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes               113.4752                      
Convertible senior notes, total ADS into which the debt is exchangeable               17,021,280                      
Convertible senior notes, payment start date         Jul. 15, 2012                            
Convertible senior notes, maturity date         Jan. 15, 2032                            
Value of shares in excess of principal amount of Notes based on closing price 23,900,000                                    
Additional interest rate on notes per annum             0.50%                        
Convertible senior notes, repurchase price at option of the issuer       100.00%                              
Proceeds allocated to conversion option           23,800,000                          
Fair value of the liability component         150,000,000 126,200,000                          
Note, estimated remaining life           24 months                          
Effective interest rate           14.50%                          
Unamortized debt discount           2,100,000           10,200,000              
Debt discount amortization period           24 months                          
Convertible senior notes, carrying amount net of unamortized discount           137,700,000                          
Interest expense, contractual coupon interest accrual           1,300,000                          
Interest expense, amortization of discount           2,900,000             600,000            
Accrued interest on convertible note 4,646,000   2,520,000     1,100,000                          
Interest payment on notes $ 2,625,000               $ 2,600,000