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Debt - Additional Information (Detail) (USD $) | 1 Months Ended | 6 Months Ended |  | 1 Months Ended | 3 Months Ended | 6 Months Ended |  | 6 Months Ended | 1 Months Ended | 6 Months Ended |  | 3 Months Ended | 6 Months Ended | 12 Months Ended |
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Jan. 31, 2012 | Jun. 30, 2013 | Jun. 30, 2012 | Dec. 31, 2012 | Jan. 31, 2012 Convertible Debt | Jun. 30, 2013 Convertible Debt | Jun. 30, 2013 Convertible Debt | Dec. 31, 2012 Convertible Debt | Jun. 30, 2013 Convertible Debt American Depository Shares | Jan. 31, 2013 3.5% exchangeable senior notes due 2032 Finance | Jun. 30, 2013 Cash | Jun. 30, 2013 Non Cash | Jun. 30, 2013 Proceeds Convertible Debt | Jun. 30, 2013 Debt Offering Convertible Debt | Jun. 30, 2013 Debt Offering Convertible Debt | Dec. 31, 2012 Biopharma | Dec. 31, 2012 Biopharma November 2013 for the fiscal quarter ended September 30, 2013 | Dec. 31, 2012 Biopharma Per quarter in each of the next four quarters | Dec. 31, 2012 Biopharma Per quarter in each of the next four quarters | Dec. 31, 2012 Biopharma Per quarter in each of the next four quarters | Dec. 31, 2012 Biopharma Final payment
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount received at the closing of the agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 100,000,000 |  |  |  |  |
Maximum repayment of future revenue and receivables |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 150,000,000 |  |  |  |  |
Future minimum repayment under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,500,000 | 8,000,000 | 10,000,000 | 15,000,000 | 13,000,000
Agreement expiration date |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Dec. 31, 2013 |  |  |  |  |
Change of control obligation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 140,000,000 |  |  |  |  |
Fair value of Embedded derivative liability |  |  |  | 14,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of derivative liability |  | 8,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gain on change in fair value of derivative liability |  | 6,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense |  |  |  |  |  |  |  |  |  |  | 7,000,000 | 1,500,000 |  |  |  |  |  |  |  |  |
Convertible senior notes, interest expense |  | 8,500,000 |  |  |  | 5,000,000 | 9,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, principal amount |  |  |  |  | 150,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, stated interest rate |  |  |  |  | 3.50% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, due date |  |  |  |  | 2032 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, net proceeds |  |  | 144,316,000 |  | 144,316,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  |  |  |  |  |  |  |  | 113.4752 |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, total ADS into which the debt is exchangeable |  |  |  |  |  |  |  |  | 17,021,280 |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, payment start date |  |  |  |  | Jul. 15, 2012 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, maturity date |  |  |  |  | Jan. 15, 2032 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Value of shares in excess of principal amount of Notes based on closing price |  | 51,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional interest rate on notes per annum |  |  |  |  |  |  |  | 0.50% |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, repurchase price at option of the issuer | 100.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds allocated to conversion option |  |  |  |  |  |  | 23,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of the liability component |  |  |  |  | 150,000,000 | 126,200,000 | 126,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Note, estimated remaining life |  |  |  |  |  |  | 24 months |  |  |  |  |  |  |  |  |  |  |  |  |  |
Effective interest rate |  |  |  |  |  | 14.50% | 14.50% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unamortized debt discount |  |  |  |  |  | 1,400,000 | 1,400,000 |  |  |  |  |  | 7,100,000 |  |  |  |  |  |  |  |
Debt discount amortization period |  |  |  |  |  |  | 24 months |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, carrying amount net of unamortized discount |  |  |  |  |  | 141,500,000 | 141,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense, contractual coupon interest accrual |  |  |  |  |  | 1,300,000 | 2,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense, amortization of discount |  |  |  |  |  | 3,100,000 | 6,000,000 |  |  |  |  |  |  | 600,000 | 1,200,000 |  |  |  |  |  |
Accrued interest on convertible note |  | 9,555,000 |  | 2,520,000 |  | 9,600,000 | 9,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest payment on notes |  | $ 2,625,000 |  |  |  |  |  |  |  | $ 2,600,000 |  |  |  |  |  |  |  |  |  |  |

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- Definition Amount of noncash expense included in interest expense to amortize debt discount and premium associated with the related debt instruments. Excludes amortization of financing costs. Alternate captions include noncash interest expense. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 30 -Section 45 -Paragraph 1A -URI http://asc.fasb.org/extlink&oid=6451184&loc=d3e28541-108399 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.8) -URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 8 -Article 5 + Details
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- Definition The number of shares issued in exchange for the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or payments in the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4332-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4304-108586 + Details
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- Definition Date the debt agreement requires the first payment to be made, in CCYY-MM-DD format. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 22 -Article 5 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.22) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 470 -Section 50 -Paragraph 3 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6479336&loc=d3e64711-112823 + Details
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- Definition The amount of cash paid for interest during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4297-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 25 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3536-108585 + Details
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- Definition Carrying value as of the balance sheet date of [accrued] interest payable on all forms of debt, including trade payables, that has been incurred and is unpaid. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 20 -Article 5 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Current Liabilities -URI http://asc.fasb.org/extlink&oid=6509677 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=28358313&loc=d3e6935-107765 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.20) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 9 -URI http://asc.fasb.org/extlink&oid=28358313&loc=d3e7018-107765 + Details
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- Definition Minimum amount of other commitment not otherwise specified in the taxonomy. Excludes commitments explicitly modeled in the taxonomy, including but not limited to, long-term and short-term purchase commitments, recorded and unrecorded purchase obligations, supply commitments, registration payment arrangements, leases, debt, product warranties, guarantees, environmental remediation obligations, and pensions. + References No definition available. + Details
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- Definition The cash inflow from the issuance of a long-term debt instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3255-108585 + Details
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- Definition The cash inflow from additional borrowings, net of cash paid to third parties in connection with debt origination. + References No definition available. + Details
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- Definition The net cash inflow or outflow from other financing activities. This element is used when there is not a more specific and appropriate element in the taxonomy. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3095-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 9 -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3098-108585 + Details
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