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Debt - Additional Information (Detail) (USD $)
 1 Months Ended 6 Months Ended 1 Months Ended 3 Months Ended 6 Months Ended 6 Months Ended 1 Months Ended 6 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Jan. 31, 2012
Jun. 30, 2013
Jun. 30, 2012
Dec. 31, 2012
Jan. 31, 2012
Convertible Debt
Jun. 30, 2013
Convertible Debt
Jun. 30, 2013
Convertible Debt
Dec. 31, 2012
Convertible Debt
Jun. 30, 2013
Convertible Debt
American Depository Shares
Jan. 31, 2013
3.5% exchangeable senior notes due 2032
Finance
Jun. 30, 2013
Cash
Jun. 30, 2013
Non Cash
Jun. 30, 2013
Proceeds
Convertible Debt
Jun. 30, 2013
Debt Offering
Convertible Debt
Jun. 30, 2013
Debt Offering
Convertible Debt
Dec. 31, 2012
Biopharma
Dec. 31, 2012
Biopharma
November 2013 for the fiscal quarter ended September 30, 2013
Dec. 31, 2012
Biopharma
Per quarter in each of the next four quarters
Dec. 31, 2012
Biopharma
Per quarter in each of the next four quarters
Dec. 31, 2012
Biopharma
Per quarter in each of the next four quarters
Dec. 31, 2012
Biopharma
Final payment
Debt Disclosure [Line Items]                                          
Amount received at the closing of the agreement                               $ 100,000,000          
Maximum repayment of future revenue and receivables                               150,000,000          
Future minimum repayment under agreement                                 2,500,000 8,000,000 10,000,000 15,000,000 13,000,000
Agreement expiration date                               Dec. 31, 2013          
Change of control obligation                               140,000,000          
Fair value of Embedded derivative liability       14,600,000                                  
Fair value of derivative liability   8,600,000                                      
Gain on change in fair value of derivative liability   6,000,000                                      
Interest expense                     7,000,000 1,500,000                  
Convertible senior notes, interest expense   8,500,000       5,000,000 9,800,000                            
Convertible senior notes, principal amount         150,000,000                                
Convertible senior notes, stated interest rate         3.50%                                
Convertible senior notes, due date         2032                                
Convertible senior notes, net proceeds     144,316,000   144,316,000                                
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes                 113.4752                        
Convertible senior notes, total ADS into which the debt is exchangeable                 17,021,280                        
Convertible senior notes, payment start date         Jul. 15, 2012                                
Convertible senior notes, maturity date         Jan. 15, 2032                                
Value of shares in excess of principal amount of Notes based on closing price   51,300,000                                      
Additional interest rate on notes per annum               0.50%                          
Convertible senior notes, repurchase price at option of the issuer 100.00%                                        
Proceeds allocated to conversion option             23,800,000                            
Fair value of the liability component         150,000,000 126,200,000 126,200,000                            
Note, estimated remaining life             24 months                            
Effective interest rate           14.50% 14.50%                            
Unamortized debt discount           1,400,000 1,400,000           7,100,000                
Debt discount amortization period             24 months                            
Convertible senior notes, carrying amount net of unamortized discount           141,500,000 141,500,000                            
Interest expense, contractual coupon interest accrual           1,300,000 2,600,000                            
Interest expense, amortization of discount           3,100,000 6,000,000             600,000 1,200,000            
Accrued interest on convertible note   9,555,000   2,520,000   9,600,000 9,600,000                            
Interest payment on notes   $ 2,625,000               $ 2,600,000