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Debt - Additional Information (Detail) (USD $)
 1 Months Ended 3 Months Ended 9 Months Ended 1 Months Ended 3 Months Ended 9 Months Ended 9 Months Ended 1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended 3 Months Ended 9 Months Ended 3 Months Ended 9 Months Ended
Jan. 31, 2012
Sep. 30, 2013
Sep. 30, 2013
Sep. 30, 2012
Dec. 31, 2012
Jan. 31, 2012
Convertible Debt
Sep. 30, 2013
Convertible Debt
Sep. 30, 2013
Convertible Debt
Dec. 31, 2012
Convertible Debt
Sep. 30, 2013
Convertible Debt
American Depository Shares
Jul. 31, 2013
3.5% exchangeable senior notes due 2032
Finance
Jan. 31, 2013
3.5% exchangeable senior notes due 2032
Finance
Sep. 30, 2013
Proceeds
Convertible Debt
Sep. 30, 2013
Debt Offering
Convertible Debt
Sep. 30, 2013
Debt Offering
Convertible Debt
Dec. 31, 2012
BioPharma Debt
Sep. 30, 2013
BioPharma Debt
November 2013 for the fiscal quarter ended September 30, 2013
Dec. 31, 2012
BioPharma Debt
November 2013 for the fiscal quarter ended September 30, 2013
Dec. 31, 2012
BioPharma Debt
Per quarter in each of the next four quarters
Dec. 31, 2012
BioPharma Debt
Per quarter in each of the next four quarters
Dec. 31, 2012
BioPharma Debt
Per quarter in each of the next four quarters
Dec. 31, 2012
BioPharma Debt
Final payment
Sep. 30, 2013
BioPharma Debt
Cash
Sep. 30, 2013
BioPharma Debt
Cash
Sep. 30, 2013
BioPharma Debt
Non Cash
Sep. 30, 2013
BioPharma Debt
Non Cash
Debt Disclosure [Line Items]                                                    
Amount received at the closing of the agreement                               $ 100,000,000                    
Maximum repayment of future revenue and receivables                               150,000,000                    
Future minimum repayment under agreement                                 800,000 2,500,000 8,000,000 10,000,000 15,000,000 13,000,000        
Agreement expiration date                               Dec. 31, 2013                    
Change of control obligation                               140,000,000                    
Fair value of Embedded derivative liability         14,600,000                                          
Fair value of derivative liability   7,200,000 7,200,000                                              
Gain on change in fair value of derivative liability   1,400,000 7,400,000                                              
Interest expense                                             2,700,000 9,700,000 600,000 2,200,000
Convertible senior notes, principal amount           150,000,000                                        
Convertible senior notes, stated interest rate           3.50%                                        
Convertible senior notes, due date           2032                                        
Convertible senior notes, net proceeds       144,316,000   144,300,000                                        
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes                   113.4752                                
Convertible senior notes, total ADS into which the debt is exchangeable                   17,021,280                                
Convertible senior notes, payment start date           Jul. 15, 2012                                        
Convertible senior notes, maturity date           Jan. 15, 2032                                        
Value of shares in excess of principal amount of Notes based on closing price   42,400,000 42,400,000                                              
Additional interest rate on notes per annum                 0.50%                                  
Convertible senior notes, repurchase price at option of the issuer 100.00%                                                  
Proceeds allocated to conversion option               23,800,000                                    
Fair value of the liability component             126,200,000 126,200,000                                    
Note, estimated remaining life               24 months                                    
Effective interest rate             14.50% 14.50%                                    
Unamortized debt discount             800,000 800,000         3,900,000                          
Debt discount amortization period               24 months                                    
Convertible senior notes, carrying amount net of unamortized discount             145,300,000 145,300,000                                    
Convertible senior notes, interest expense             5,200,000 15,000,000                                    
Interest expense, contractual coupon interest accrual             1,300,000 3,900,000                                    
Interest expense, amortization of discount             3,200,000 9,200,000           700,000 1,900,000                      
Accrued interest on convertible note   10,901,000 10,901,000   2,520,000   1,100,000 1,100,000                                    
Interest payment on notes     $ 5,250,000 $ 2,713,000             $ 2,600,000 $ 2,600,000