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Condensed Consolidated Statements of Operations (USD $)
In Thousands, except Share data, unless otherwise specified
 3 Months Ended 9 Months Ended
Sep. 30, 2013
Sep. 30, 2012
Sep. 30, 2013
Sep. 30, 2012
Product revenues $ 8,403   $ 16,245  
Operating Expenses:        
Cost of goods sold 3,682   7,813  
Research and development 16,821 20,913 56,148 39,735
Selling, general and administrative 28,274 13,397 101,502 41,059
Total operating expenses 48,777 34,310 165,463 80,794
Operating loss (40,374) (34,310) (149,218) (80,794)
(Loss) gain on change in fair value of derivative liabilities (1,402) 16,454 21,059 (68,686)
Interest expense, net (8,441) (4,570) (26,646) (12,838)
Other (expense) income, net (302) (427) (838) (411)
Loss from operations before income taxes (50,519) (22,853) (155,643) (162,729)
Benefit from (provision for) income taxes 1,635 (3,573) 4,827 (5,888)
Net loss $ (48,884) $ (26,426) $ (150,816) $ (168,617)
Loss per share:        
Basic and diluted $ (0.29) $ (0.18) $ (0.96) $ (1.19)
Weighted average shares:        
Basic and diluted 170,187 149,200 157,105 141,947