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Debt - Additional Information (Detail) (USD $)
 1 Months Ended 3 Months Ended 1 Months Ended 3 Months Ended 3 Months Ended 12 Months Ended 3 Months Ended
Jan. 31, 2012
Mar. 31, 2014
Mar. 31, 2013
Dec. 31, 2013
Dec. 31, 2012
Jan. 31, 2012
Convertible Debt
Mar. 31, 2014
Convertible Debt
Mar. 31, 2013
Convertible Debt
Mar. 31, 2014
Convertible Debt
American Depository Shares
Mar. 31, 2014
Convertible Debt
Other current liabilities
Mar. 31, 2013
Convertible Debt
Other current liabilities
Mar. 31, 2014
Convertible Debt
Debt Offering
Mar. 31, 2013
Convertible Debt
Debt Offering
Mar. 31, 2014
Convertible Debt
3.5% exchangeable senior notes due 2032
Finance
Mar. 31, 2013
Convertible Debt
3.5% exchangeable senior notes due 2032
Finance
Dec. 31, 2012
Biopharma Debt
Mar. 31, 2014
Biopharma Debt
Mar. 31, 2014
Biopharma Debt
November 2013
Mar. 31, 2014
Biopharma Debt
February 2014
Mar. 31, 2014
Biopharma Debt
May 2014
Mar. 31, 2014
Biopharma Debt
Third quarter of 2014 and in each of the next two quarters
Mar. 31, 2014
Biopharma Debt
Per quarter in each of the next four quarters
Mar. 31, 2014
Biopharma Debt
Per quarter in each of the next four quarters
Mar. 31, 2014
Biopharma Debt
Final Payment
Mar. 31, 2014
Biopharma Debt
Cash
Mar. 31, 2013
Biopharma Debt
Cash
Mar. 31, 2014
Biopharma Debt
Non Cash
Mar. 31, 2013
Biopharma Debt
Non Cash
Debt Disclosure [Line Items]                                                        
Amount received at the closing of the agreement                               $ 100,000,000                        
Maximum repayment of future revenue and receivables                                 150,000,000                      
Future minimum repayment under agreement                                   800,000 1,000,000 1,100,000 8,000,000 10,000,000 15,000,000 13,000,000        
Agreement expiration date                               Dec. 31, 2013                        
Change of control obligation                                 140,000,000                      
Fair value of Embedded derivative liability         14,600,000                                              
Gain (Loss)on change in fair value of derivative liability   3,500,000 (1,000,000)                                                  
Interest expense                                                 1,900,000 3,400,000 500,000 700,000
Convertible senior notes, principal amount           150,000,000                                            
Convertible senior notes, stated interest rate           3.50%                                            
Convertible senior notes, due date           2032                                            
Convertible senior notes, net proceeds 144,300,000                                                      
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes                 113.4752                                      
Convertible senior notes, total ADS into which the debt is exchangeable                 17,021,280                                      
Convertible senior notes, payment start date           Jul. 15, 2012                                            
Convertible senior notes, maturity date           Jan. 15, 2032                                            
Value of shares in excess of principal amount of Notes based on closing price   119,200,000                                                    
Additional interest rate on notes per annum             0.50%                                          
Convertible senior notes, repurchase price at option of the issuer 100.00%                                                      
Proceeds allocated to conversion option             23,800,000                                          
Fair value of the liability component             126,200,000                                          
Note, estimated remaining life             24 months                                          
Effective interest rate             14.50%                                          
Debt discount amortization period   24 months                                                    
Unamortized debt discount               2,100,000                                        
Convertible notes, carrying amount net of unamortized discount   150,000,000 137,700,000                                                  
Convertible notes, interest expense             2,000,000 4,800,000                                        
Interest expense, contractual coupon interest accrual             1,300,000 1,300,000                                        
Interest expense, amortization of discount             600,000 2,900,000       100,000 600,000                              
Accrued interest on convertible note   12,569,000   12,974,000           1,100,000 2,400,000                                  
Interest payment on notes   $ 3,636,000 $ 2,625,000                     $ 2,600,000 $ 5,300,000