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Debt - Additional Information (Detail) (USD $)
 3 Months Ended 6 Months Ended 6 Months Ended 6 Months Ended 12 Months Ended 1 Months Ended 3 Months Ended 6 Months Ended 6 Months Ended 1 Months Ended 6 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended 6 Months Ended
Jun. 30, 2014
Jun. 30, 2014
Jun. 30, 2013
Dec. 31, 2013
Dec. 31, 2012
Jun. 30, 2014
Convertible Debt
Dec. 31, 2013
Convertible Debt
Jun. 30, 2014
Convertible Debt
Finance
Dec. 31, 2013
Convertible Debt
Finance
Jan. 31, 2012
Convertible Debt
2012 Notes
Mar. 31, 2014
Convertible Debt
2012 Notes
Jun. 30, 2014
Convertible Debt
2012 Notes
May 31, 2014
Convertible Debt
2012 Notes
Dec. 31, 2013
Convertible Debt
2012 Notes
Jun. 30, 2014
Convertible Debt
2012 Notes
American Depository Shares
May 31, 2014
Convertible Debt
2012 Notes
Exchanged Debt
May 31, 2014
Convertible Debt
2014 Notes
Jun. 30, 2014
Convertible Debt
2014 Notes
D
Jun. 30, 2014
Convertible Debt
2014 Notes
American Depository Shares
Jun. 30, 2014
Convertible Debt
2014 Notes
Minimum
Jun. 30, 2014
Biopharma Debt
Jun. 30, 2014
Biopharma Debt
Dec. 31, 2012
Biopharma Debt
Jun. 30, 2014
Biopharma Debt
August 2014
Jun. 30, 2014
Biopharma Debt
Fourth quarter of 2014 and in the next quarter thereafter
Jun. 30, 2014
Biopharma Debt
Per quarter in each of the next four quarters
Jun. 30, 2014
Biopharma Debt
Per quarter in each of the next four quarters
Jun. 30, 2014
Biopharma Debt
Final Payment
Jun. 30, 2014
Biopharma Debt
Cash
Jun. 30, 2013
Biopharma Debt
Cash
Jun. 30, 2014
Biopharma Debt
Non Cash
Jun. 30, 2013
Biopharma Debt
Non Cash
Debt Disclosure [Line Items]                                                                
Amount received at the closing of the agreement                                             $ 100,000,000                  
Maximum repayment of future revenue and receivables                                         147,100,000 147,100,000 150,000,000                  
Repayment under agreement                                         1,100,000 2,100,000                    
Future minimum repayment under agreement                                               1,300,000 8,000,000 10,000,000 15,000,000 13,000,000        
Agreement expiration date                                             Dec. 31, 2013                  
Change of control obligation                                         140,000,000 140,000,000                    
Fair value of Embedded derivative liability         14,600,000                         3,300,000                            
Gain (Loss) on change in fair value of derivative liability   5,000,000 6,000,000                                                          
Interest expense                                                         3,800,000 7,000,000 1,000,000 1,500,000
Convertible senior notes, principal amount                   150,000,000     31,300,000     118,700,000 118,700,000                              
Convertible senior notes, stated interest rate                   3.50%             3.50%                              
Convertible senior notes, due date                   2032             2032                              
Convertible senior notes, net proceeds                   144,300,000                                            
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes                             113.4752       384.6154                          
Convertible senior notes, total ADS into which the debt is exchangeable                             3,547,916       45,666,925                          
Convertible senior notes, payment start date                   Jul. 15, 2012               Jul. 15, 2014                            
Convertible senior notes, maturity date                   Jan. 15, 2032               Jan. 15, 2032                            
Additional interest rate on notes per annum                       0.50%                                        
Convertible senior notes, repurchase price at option of the issuer                   100.00%             10000.00%                              
Proceeds allocated to conversion option                     23,800,000                                          
Convertible senior notes, fair value                     126,200,000 22,900,000   106,600,000       93,600,000                            
Note, estimated remaining life                     24 months                                          
Debt discount amortization period                       24 months                                        
Carrying value of 2014 notes                       31,300,000           87,900,000                            
Convertible senior notes, initial exchange price                                     $ 2.60                          
Convertible senior notes redemption, end date                                   Jan. 15, 2032                            
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price                                       110.00%                        
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, at least number of VWAP Trading days                                       20 days                        
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, in any number of VWAP Trading days                                   30                            
Decrease to additional paid-in capital,representing reacquisition of conversion option in convertible notes   10,100,000                   10,100,000                                        
Convertible senior notes, fair value                                 90,800,000                              
Convertible senior notes, discount           3,500,000           0   700,000     27,900,000 27,900,000                            
Underwriter's fees and offering costs                                 2,400,000                              
Gain on extinguishment of debt 38,034,000 38,034,000                   38,000,000                                        
Convertible notes, interest expense           2,000,000                                                    
Interest expense, amortization of discount           700,000                                                    
Interest expense, contractual coupon interest accrual           1,300,000                                                    
Accrued interest on convertible note 14,669,000 14,669,000   12,974,000   2,400,000 2,400,000                                                  
Interest payment on notes   $ 4,732,000 $ 2,625,000         $ 2,600,000 $ 2,600,000