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Debt - Additional Information (Detail) (USD $) | 3 Months Ended | 9 Months Ended |  |  | 3 Months Ended | 9 Months Ended |  | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |  | 9 Months Ended |  | 1 Months Ended | 9 Months Ended | 12 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |  | 9 Months Ended
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Sep. 30, 2014 | Sep. 30, 2013 | Sep. 30, 2014 | Sep. 30, 2013 | Dec. 31, 2013 | Dec. 31, 2012 | Sep. 30, 2014 Convertible Debt | Sep. 30, 2014 Convertible Debt | Dec. 31, 2013 Convertible Debt | Jan. 31, 2012 Convertible Debt 2012 Notes | Mar. 31, 2014 Convertible Debt 2012 Notes | Sep. 30, 2014 Convertible Debt 2012 Notes | May 31, 2014 Convertible Debt 2012 Notes | Dec. 31, 2013 Convertible Debt 2012 Notes | Sep. 30, 2014 Convertible Debt 2012 Notes American Depository Shares | May 31, 2014 Convertible Debt 2012 Notes Exchanged Debt | May 31, 2014 Convertible Debt 2014 Notes | Sep. 30, 2014 Convertible Debt 2014 Notes D | Sep. 30, 2014 Convertible Debt 2014 Notes American Depository Shares | Sep. 30, 2014 Convertible Debt 2014 Notes Minimum | Sep. 30, 2014 Convertible Debt Finance | Dec. 31, 2013 Convertible Debt Finance | Sep. 30, 2014 Biopharma Debt | Sep. 30, 2014 Biopharma Debt | Dec. 31, 2012 Biopharma Debt | Sep. 30, 2014 Biopharma Debt November 2014 | Sep. 30, 2014 Biopharma Debt First quarter of 2015 | Sep. 30, 2014 Biopharma Debt Per quarter in each of the next four quarters | Sep. 30, 2014 Biopharma Debt Per quarter in each of the next four quarters | Sep. 30, 2014 Biopharma Debt Final Payment | Sep. 30, 2014 Biopharma Debt Cash | Sep. 30, 2013 Biopharma Debt Cash | Sep. 30, 2014 Biopharma Debt Non Cash | Sep. 30, 2013 Biopharma Debt Non Cash
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount received at the closing of the agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 100,000,000 |  |  |  |  |  |  |  |  |
Maximum repayment of future revenue and receivables |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 145,800,000 | 145,800,000 | 150,000,000 |  |  |  |  |  |  |  |  |
Repayment under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,300,000 | 3,400,000 |  |  |  |  |  |  |  |  |  |
Future minimum repayment under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,400,000 | 8,000,000 | 10,000,000 | 15,000,000 | 13,000,000 |  |  |  |
Percentage of net revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10.00% |  |  |  |  |  |  |  |  |  |
Fair value of Embedded derivative liability |  |  |  |  |  | 14,600,000 |  |  |  |  |  |  |  |  |  |  |  | 4,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  | 6,500,000 | 7,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,500,000 | 9,700,000 | 1,400,000 | 2,200,000
Convertible senior notes, principal amount |  |  |  |  |  |  |  |  |  | 150,000,000 |  |  | 31,300,000 |  |  | 118,700,000 | 118,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, stated interest rate |  |  |  |  |  |  |  |  |  | 3.50% |  |  |  |  |  |  | 3.50% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, due date |  |  |  |  |  |  |  |  |  | 2032 |  |  |  |  |  |  | 2032 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, net proceeds |  |  |  |  |  |  |  |  |  | 144,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 113.4752 |  |  |  | 384.6154 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, total ADS into which the debt is exchangeable |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,547,916 |  |  |  | 45,666,925 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, payment start date |  |  |  |  |  |  |  |  |  | Jul. 15, 2012 |  |  |  |  |  |  |  | Jul. 15, 2014 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, maturity date |  |  |  |  |  |  |  |  |  | Jan. 15, 2032 |  |  |  |  |  |  |  | Jan. 15, 2032 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional interest rate on notes per annum |  |  |  |  |  |  |  |  |  |  |  | 0.50% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, repurchase price at option of the issuer |  |  |  |  |  |  |  |  |  | 100.00% |  |  |  |  |  |  | 10000.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds allocated to conversion option |  |  |  |  |  |  |  |  |  |  | 23,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, fair value |  |  |  |  |  |  |  |  |  |  | 126,200,000 | 24,100,000 |  | 106,600,000 |  |  |  | 78,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Note, estimated remaining life |  |  |  |  |  |  |  |  |  |  | 24 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt discount amortization period |  |  |  |  |  |  |  |  |  |  |  | 24 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Carrying value of 2014 notes |  |  |  |  |  |  |  |  |  |  |  | 31,300,000 |  |  |  |  |  | 89,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, initial exchange price |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 2.60 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes redemption, end date |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Jan. 15, 2032 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 110.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, at least number of VWAP Trading days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20 days |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, in any number of VWAP Trading days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 30 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Decrease to additional paid-in capital,representing reacquisition of conversion option in convertible notes |  |  | 10,100,000 |  |  |  |  |  |  |  |  | 10,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, fair value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 90,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  |  |  | 3,500,000 | 3,500,000 |  |  |  | 0 |  | 700,000 |  |  | 27,900,000 | 27,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Underwriter's fees and offering costs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gain on extinguishment of debt |  |  | 38,034,000 |  |  |  |  |  |  |  |  | 38,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gain (loss) on change in fair value of derivative liability | 4,466,000 | (1,402,000) | 11,870,000 | 21,059,000 |  |  | (1,100,000) |  |  |  |  |  |  |  |  |  |  | 900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Long-term debt derivative liability | 9,000,000 |  | 9,000,000 |  | 11,100,000 |  | 4,400,000 | 4,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible notes, interest expense |  |  |  |  |  |  |  | 6,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense, amortization of discount |  |  |  |  |  |  |  | 2,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense, contractual coupon interest accrual |  |  |  |  |  |  |  | 3,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued interest on convertible note |  |  |  |  |  |  | 1,100,000 | 1,100,000 | 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest payment on notes |  |  | $ 8,622,000 | $ 5,250,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 5,300,000 | $ 5,300,000 |  |  |  |  |  |  |  |  |  |  |  |

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- Definition Amount of noncash expense included in interest expense to amortize debt discount and premium associated with the related debt instruments. Excludes amortization of financing costs. Alternate captions include noncash interest expense. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 30 -Section 45 -Paragraph 1A -URI http://asc.fasb.org/extlink&oid=6451184&loc=d3e28541-108399 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.8) -URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 8 -Article 5 + Details
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- Definition Date when the debt instrument is scheduled to be fully repaid, in CCYY-MM-DD format. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 22 -Article 5 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.22(a)(2)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition End date of debt instrument redemption period, in CCYY-MM-DD format. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 470 -Section 50 -Paragraph 3 -Subparagraph e -URI http://asc.fasb.org/extlink&oid=6479336&loc=d3e64711-112823 + Details
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- Definition Percentage price of original principal amount of debt at which debt can be redeemed by the issuer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 470 -Section 50 -Paragraph 3 -Subparagraph e -URI http://asc.fasb.org/extlink&oid=6479336&loc=d3e64711-112823 + Details
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- Definition Period of time between issuance and maturity of debt instrument, in PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References No definition available. + Details
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- Definition The amount of debt discount that was originally recognized at the issuance of the instrument that has yet to be amortized. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 30 -Section 45 -Paragraph 1A -URI http://asc.fasb.org/extlink&oid=6451184&loc=d3e28541-108399 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 30 -Section 55 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=34725769&loc=d3e28878-108400 + Details
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- Definition Amount of debt issuance costs (for example, but not limited to, legal, accounting, broker, and regulatory fees). + References No definition available. + Details
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- Definition Fair value, after the effects of master netting arrangements, of a financial liability or contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset, expected to be settled after one year or the normal operating cycle, if longer. Includes assets not subject to a master netting arrangement and not elected to be offset. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 10 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=35750535&loc=d3e13433-108611 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 815 -SubTopic 10 -Section 45 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6945355&loc=d3e41228-113958 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=35750535&loc=d3e13495-108611 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 20 -Section 50 -Paragraph 3 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=34720828&loc=SL20225862-175312 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 815 -SubTopic 10 -Section 45 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=6945355&loc=d3e41271-113958 + Details
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- Definition Fair value as of the balance sheet date of the embedded derivative or group of embedded derivatives classified as a liability. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 815 -SubTopic 10 -Section 50 -Paragraph 4B -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=35706170&loc=SL5624163-113959 + Details
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- Definition Aggregate net gain (loss) on all derivative instruments recognized in earnings during the period, before tax effects. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 815 -SubTopic 10 -Section 50 -Paragraph 4A -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=35706170&loc=SL5618551-113959 + Details
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- Definition Difference between the fair value of payments made and the carrying amount of debt which is extinguished prior to maturity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 50 -Section 40 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6850294&loc=d3e12317-112629 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 50 -Section 40 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=6850294&loc=d3e12355-112629 + Details
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- Definition Amount of the cost of borrowed funds accounted for as interest expense. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6450988&loc=d3e26243-108391 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 225 -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-04.9) -URI http://asc.fasb.org/extlink&oid=6879574&loc=d3e536633-122882 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 04 -Paragraph 9 -Article 9 + Details
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- Definition Minimum amount of other commitment not otherwise specified in the taxonomy. Excludes commitments explicitly modeled in the taxonomy, including but not limited to, long-term and short-term purchase commitments, recorded and unrecorded purchase obligations, supply commitments, registration payment arrangements, leases, debt, product warranties, guarantees, environmental remediation obligations, and pensions. + References No definition available. + Details
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- Definition The cash inflow from the issuance of a long-term debt instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3255-108585 + Details
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