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Related Party Transaction - Additional Information (Detail) (USD $) In Thousands, except Share data, unless otherwise specified	1 Months Ended
	Oct. 31, 2009 Point	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Related Party Transaction [Line Items]
Derivative liability		$ 7,519us-gaap_DerivativeLiabilities	$ 17,994us-gaap_DerivativeLiabilities	$ 69,431us-gaap_DerivativeLiabilities
October 2009 Private Placement \| Warrant
Related Party Transaction [Line Items]
Derivative liability		100
Derivative liability, fair value		$ 65
October 2009 Private Placement \| American Depository Shares
Related Party Transaction [Line Items]
Purchase of ADSs (in the form of common stock) by directors in private placement	36,000,000
Number of ADS that can be purchased for each warrant received	0.5
October 2009 Private Placement \| American Depository Shares \| Abingworth LLP
Related Party Transaction [Line Items]
Purchase of ADSs (in the form of common stock) by directors in private placement	17,000,000
October 2009 Private Placement \| American Depository Shares \| Orbimed Advisors LLC
Related Party Transaction [Line Items]
Purchase of ADSs (in the form of common stock) by directors in private placement	7,000,000
October 2009 Private Placement \| American Depository Shares \| Sofinnova Venture Partners VII, LP
Related Party Transaction [Line Items]
Purchase of ADSs (in the form of common stock) by directors in private placement	7,000,000
October 2009 Private Placement \| American Depository Shares \| Fountain Healthcare Partners Fund 1, LP
Related Party Transaction [Line Items]
Purchase of ADSs (in the form of common stock) by directors in private placement	5,000,000

Fair value, after the effects of master netting arrangements, of a financial liability or contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset. Includes liabilities not subject to a master netting arrangement and not elected to be offset.

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