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Debt - Additional Information (Detail) $ / shares in Units, $ in Thousands |  | 1 Months Ended | 3 Months Ended | 6 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Jun. 30, 2015 USD ($) | May. 31, 2014 USD ($) shares d $ / shares | Jan. 31, 2012 USD ($) shares $ / shares | Jun. 30, 2015 USD ($) | Jun. 30, 2014 USD ($) | Jun. 30, 2015 USD ($) | Jun. 30, 2014 USD ($) | Dec. 31, 2014 USD ($) | Dec. 06, 2012 USD ($)
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Gain on extinguishment of debt |  |  |  |  | $ 38,034 |  | $ 38,034 |  |
Gain (loss) on change in fair value of derivative liability |  |  |  | $ (600) | $ 3,011 | $ (136) | 7,404 |  |
Interest payment on notes |  |  |  |  |  | 5,829 | 4,732 |  |
Convertible Debt |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Derivative liability at fair value |  | $ 3,500 |  |  |  |  |  |  |
Gain (loss) on change in fair value of derivative liability |  |  |  |  |  | 1,500 |  |  |
Convertible notes, interest expense |  |  |  |  |  | 5,600 | 3,900 |  |
Interest expense, amortization of discount |  |  |  |  |  | 3,000 | 1,300 |  |
Interest expense, contractual coupon interest accrual |  |  |  |  |  | 2,600 | 2,600 |  |
Accrued interest on convertible note | $ 2,400 |  |  | 2,400 |  | 2,400 |  | $ 2,400 |
Convertible Debt | Finance |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Interest payment on notes |  |  |  |  |  | 2,600 | 2,600 |  |
Convertible Debt | 2012 Notes |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Convertible senior notes, principal amount |  | 31,300 | $ 150,000 |  |  |  |  |  |
Convertible senior notes, stated interest rate |  |  | 3.50% |  |  |  |  |  |
Convertible senior notes, due date |  |  | 2032 |  |  |  |  |  |
Convertible senior notes, net proceeds |  |  | $ 144,300 |  |  |  |  |  |
Convertible senior notes, payment start date |  |  | Jul. 15, 2012 |  |  |  |  |  |
Convertible senior notes, maturity date |  |  | Jan. 15, 2032 |  |  |  |  |  |
Value of shares in excess of principal amount of Notes based on closing price | 22,500 |  |  | 22,500 |  | 22,500 |  |  |
Additional interest rate on notes per annum |  |  | 0.50% |  |  |  |  |  |
Convertible senior notes, repurchase price at option of the issuer |  |  | 100.00% |  |  |  |  |  |
Excess of principal amount of debt over the liability component |  |  | $ 23,800 |  |  |  |  |  |
Convertible senior notes, fair value | 27,066 |  |  | 27,066 |  | 27,066 |  | 25,689 |
Note, estimated remaining life |  |  | 24 months |  |  |  |  |  |
Debt discount amortization period |  |  | 24 months |  |  |  |  |  |
Convertible notes, carrying amount net of unamortized discount | 31,300 |  |  | 31,300 |  | 31,300 |  | 31,300 |
Decrease to additional paid-in capital for repurchase of conversion option in convertible notes |  | 10,100 |  |  |  |  |  |  |
Convertible senior notes, discount | 0 |  |  | 0 |  | 0 |  | 0 |
Gain on extinguishment of debt |  | 38,000 |  |  |  |  |  |  |
Convertible Debt | 2012 Notes | American Depository Shares |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  |  | 113.4752 |  |  |  |  |  |
Convertible senior notes, total ADS into which the debt is exchangeable | shares |  |  | 3,547,916 |  |  |  |  |  |
Convertible senior notes, initial exchange price | $ / shares |  |  | $ 8.8125 |  |  |  |  |  |
Convertible Debt | 2012 Notes | Exchanged Debt |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Convertible senior notes, principal amount |  | 118,700 |  |  |  |  |  |  |
Convertible Debt | 2014 Notes |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Fair value of embedded derivative liability | 1,100 |  |  | 1,100 |  | 1,100 |  | 2,600 |
Convertible senior notes, principal amount |  | $ 118,700 |  |  |  |  |  |  |
Convertible senior notes, stated interest rate |  | 3.50% |  |  |  |  |  |  |
Convertible senior notes, due date |  | 2032 |  |  |  |  |  |  |
Convertible senior notes, payment start date |  | Jul. 15, 2014 |  |  |  |  |  |  |
Convertible senior notes, maturity date |  | Jan. 15, 2032 |  |  |  |  |  |  |
Value of shares in excess of principal amount of Notes based on closing price | 6,400 |  |  | 6,400 |  | 6,400 |  |  |
Convertible senior notes, repurchase price at option of the issuer |  | 100.00% |  |  |  |  |  |  |
Convertible senior notes, fair value | 131,406 | $ 90,800 |  | 131,406 |  | 131,406 |  | 75,533 |
Convertible notes, carrying amount net of unamortized discount | 93,400 |  |  | 93,400 |  | 93,400 |  | 90,600 |
Convertible senior notes redemption, end date |  | Jan. 15, 2032 |  |  |  |  |  |  |
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, in any number of VWAP Trading days | d |  | 30 |  |  |  |  |  |  |
Convertible senior notes, discount |  | $ 27,900 |  |  |  |  |  |  |
Underwriter's fees and offering costs |  | $ 2,500 |  |  |  |  |  |  |
Gain (loss) on change in fair value of derivative liability | 1,500 |  |  |  |  |  |  |  |
Convertible Debt | 2014 Notes | American Depository Shares |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  | 384.6154 |  |  |  |  |  |  |
Convertible senior notes, total ADS into which the debt is exchangeable | shares |  | 45,666,925 |  |  |  |  |  |  |
Convertible senior notes, initial exchange price | $ / shares |  | $ 2.60 |  |  |  |  |  |  |
Convertible Debt | 2014 Notes | Minimum |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price |  | 110.00% |  |  |  |  |  |  |
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, at least number of VWAP Trading days |  | 20 days |  |  |  |  |  |  |
Convertible Debt | Other debt outstanding | 2012 Notes |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Convertible senior notes, fair value |  |  | $ 126,200 |  |  |  |  |  |
Convertible Debt | Non Cash | 2014 Notes |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Convertible senior notes, discount | 25,400 |  |  | 25,400 |  | 25,400 |  | $ 28,200 |
Biopharma Debt |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Amount received at the closing of the agreement |  |  | 100,000 |  |  |  |  |  |
Maximum repayment of future revenue and receivables | 141,200 |  |  | 141,200 |  | 141,200 |  |  | $ 150,000
Repayment under agreement |  |  |  | 1,600 |  | 3,200 |  |  |
Fair value of embedded derivative liability |  |  | $ 14,600 |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  |  |  |  | (800) | 5,000 |  |
Biopharma Debt | August 2015 |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Future minimum repayment under agreement | 1,800 |  |  | 1,800 |  | 1,800 |  |  |
Biopharma Debt | Fourth quarter of 2015 and first quarter of 2016 |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Future minimum repayment under agreement | 10,000 |  |  | 10,000 |  | 10,000 |  |  |
Biopharma Debt | Per quarter in each of the next four quarters |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Future minimum repayment under agreement | 15,000 |  |  | 15,000 |  | 15,000 |  |  |
Biopharma Debt | Final Payment in May 2017 |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Future minimum repayment under agreement | $ 13,000 |  |  | $ 13,000 |  | 13,000 |  |  |
Biopharma Debt | Cash |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Interest expense |  |  |  |  |  | 3,200 | 3,800 |  |
Biopharma Debt | Non Cash |  |  |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Interest expense |  |  |  |  |  | $ 900 | $ 1,000 |  |

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- Definition Fair value, before effects of master netting arrangements, of a financial liability or contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset. Includes liabilities elected not to be offset. Excludes liabilities not subject to a master netting arrangement. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 860 -SubTopic 20 -Section 50 -Paragraph 4D -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=51814546&loc=SL51823488-111719 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 20 -Section 50 -Paragraph 3 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=51824906&loc=SL20225862-175312 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 815 -SubTopic 10 -Section 50 -Paragraph 4B -Subparagraph (a),(c) -URI http://asc.fasb.org/extlink&oid=56946850&loc=SL5624163-113959 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 20 -Section 55 -Paragraph 7 -URI http://asc.fasb.org/extlink&oid=51825145&loc=SL20226000-175313 + Details
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- Definition Difference between the fair value of payments made and the carrying amount of debt which is extinguished prior to maturity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 50 -Section 40 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=49170532&loc=d3e12317-112629 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 50 -Section 40 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=49170532&loc=d3e12355-112629 + Details
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