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Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2015
Summarize Activity of the Net Product Revenue Allowance and Reserve Categories | The following table summarizes activity in each of the net product revenue allowance and reserve categories described above for the years ended December 31, 2015 and 2014 (in thousands):
|  | Trade Allowances |  |  | Rebates, Chargebacks and Discounts |  |  | Product Returns |  |  | Other Incentives |  |  | Total |
Balance as of January 1, 2014 |  | $ | 1,071 |  |  | $ | 1,137 |  |  | $ | 72 |  |  | $ | 189 |  |  | $ | 2,469 |
Provision related to current period sales |  |  | 8,157 |  |  |  | 12,753 |  |  |  | 397 |  |  |  | 11,153 |  |  |  | 32,460 |
Provision related to prior period sales |  |  | (29 | ) |  |  | (80 | ) |  |  | 12 |  |  |  | (31 | ) |  |  | (128 | )
Credits/payments made for current period sales |  |  | (5,950 | ) |  |  | (9,143 | ) |  |  | — |  |  |  | (10,338 | ) |  |  | (25,431 | )
Credits/payments made for prior period sales |  |  | (1,042 | ) |  |  | (1,057 | ) |  |  | — |  |  |  | (181 | ) |  |  | (2,280 | )
Balance as of December 31, 2014 |  | $ | 2,207 |  |  | $ | 3,610 |  |  | $ | 481 |  |  | $ | 792 |  |  | $ | 7,090 |
Provision related to current period sales |  |  | 14,986 |  |  |  | 32,591 |  |  |  | 342 |  |  |  | 8,310 |  |  |  | 56,229 |
Provision related to prior period sales |  |  | (174 | ) |  |  | (70 | ) |  |  | (205 | ) |  |  | — |  |  |  | (449 | )
Credits/payments made for current period sales |  |  | (10,690 | ) |  |  | (22,710 | ) |  |  | — |  |  |  | (7,226 | ) |  |  | (40,626 | )
Credits/payments made for prior period sales |  |  | (2,033 | ) |  |  | (3,540 | ) |  |  | (83 | ) |  |  | (792 | ) |  |  | (6,448 | )
Balance as of December 31, 2015 |  | $ | 4,296 |  |  | $ | 9,881 |  |  | $ | 535 |  |  | $ | 1,084 |  |  | $ | 15,796 |
Summarizes the Impact of Accounts Receivable Reserves on Gross Trade Accounts Receivable | The following table summarizes the impact of accounts receivable reserves on the gross trade accounts receivable balances as of December 31, 2015 and 2014 (in thousands):
|  | December 31, 2015 |  |  | December 31, 2014 |
Gross trade accounts receivable |  | $ | 18,270 |  |  | $ | 10,215 |
Trade allowances |  |  | (4,296 | ) |  |  | (2,207 | )
Chargebacks |  |  | (148 | ) |  |  | (166 | )
Accounts receivable, net |  | $ | 13,826 |  |  | $ | 7,842 |
Estimated Useful Lives | The estimated useful lives, by asset classification, are as follows:
Asset Classification |  | Useful Lives
Computer equipment and software |  | 3 - 5 years
Furniture and fixtures |  | 5 years
Leasehold improvements |  | Lesser of useful life or lease term
Net Loss and the Number of Shares Used to Compute Basic and Diluted Net Loss per Share | The calculation of net loss and the number of shares used to compute basic and diluted net loss per share for the years ended December 31, 2015, 2014 and 2013 are as follows:
In thousands |  | 2015 |  |  | 2014 |  |  | 2013 |
Net loss |  | $ | (115,204 | ) |  | $ | (56,364 | ) |  | $ | (166,227 | )
Preferred stock purchase option (see Note 10) |  |  | (868 | ) |  |  | — |  |  |  | — |
Preferred stock beneficial conversion features (see Note 10) |  |  | (32,987 | ) |  |  | — |  |  |  | — |
Net loss applicable to common shareholders—basic |  |  | (149,059 | ) |  |  | (56,364 | ) |  |  | (166,227 | )
Gain on warrant derivative liability |  |  | — |  |  |  | (6,775 | ) |  |  | (47,936 | )
Net loss—diluted |  |  | (149,059 | ) |  |  | (63,139 | ) |  |  | (214,163 | )
Net loss per share—basic |  | $ | (0.83 | ) |  | $ | (0.32 | ) |  | $ | (1.03 | )
Weighted average shares outstanding—basic |  |  | 180,654 |  |  |  | 173,719 |  |  |  | 161,022 |
Effect of dilutive warrants |  |  | — |  |  |  | 105 |  |  |  | 6,048 |
Weighted average shares outstanding—diluted |  |  | 180,654 |  |  |  | 173,824 |  |  |  | 167,070 |
Net loss per share—diluted |  | $ | (0.83 | ) |  | $ | (0.36 | ) |  | $ | (1.28 | )
Anti-Dilutive Securities Not Included in the Computation of Net Loss or Earnings per Share | For the years ended December 31, 2015, 2014 and 2013, the following potentially dilutive securities were not included in the computation of net loss per share because the effect would be anti-dilutive:
In thousands |  | 2015 |  |  | 2014 |  |  | 2013 |
Stock options |  |  | 17,818 |  |  |  | 10,670 |  |  |  | 9,330 |
Restricted stock and restricted stock units |  |  | 10,887 |  |  |  | 2,256 |  |  |  | 196 |
Warrants |  |  | — |  |  |  | — |  |  |  | 1,702 |
Exchangeable senior notes (if converted) |  |  | 59,407 |  |  |  | 49,215 |  |  |  | 17,021 |
Preferred stock (if converted) |  |  | 32,818 |  |  |  | — |  |  |  | — |
Assets and Liability Measured at Fair Value on a Recurring Basis | The following tables present information about the Company’s assets and liabilities as of December 31, 2015 and 2014 that are measured at fair value on a recurring basis and indicate the fair value hierarchy of the valuation techniques the Company utilized to determine such fair value:
|  | December 31, 2015 |
In thousands |  | Total |  |  | Level 1 |  |  | Level 2 |  |  | Level 3 |
Asset: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash equivalents—money markets |  | $ | 14,184 |  |  | $ | 14,184 |  |  | $ | — |  |  | $ | — |
Liabilities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Long-term debt derivative liabilities |  | $ | 8,170 |  |  | $ | — |  |  | $ | — |  |  | $ | 8,170 |
|  | December 31, 2014 |
In thousands |  | Total |  |  | Level 1 |  |  | Level 2 |  |  | Level 3 |
Asset: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash equivalents—money markets |  | $ | 65,156 |  |  | $ | 65,156 |  |  | $ | — |  |  | $ | — |
Liabilities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant derivative liability |  | $ | 119 |  |  | $ | — |  |  | $ | — |  |  | $ | 119 |
Long-term debt derivative liabilities |  | $ | 7,400 |  |  | $ | — |  |  | $ | — |  |  | $ | 7,400 |
Carrying Amounts and Estimated Fair Values of Debt Instruments | The carrying amounts and the estimated fair values of debt instruments as of December 31, 2015 and 2014 are as follows:
|  | December 31, 2015 |  |  | December 31, 2014 |
In thousands |  | Carrying Value |  |  | Estimated Fair Value |  |  | Carrying Value |  |  | Estimated Fair Value |
Long-term debt—December 2012 financing |  | $ | 91,512 |  |  | $ | 87,700 |  |  | $ | 89,617 |  |  | $ | 81,000 |
2012 Notes |  |  | 15,107 |  |  |  | 13,637 |  |  |  | 31,266 |  |  |  | 25,689 |
2014 Notes |  |  | 96,364 |  |  |  | 108,034 |  |  |  | 90,580 |  |  |  | 75,533 |
2015 Notes |  |  | 27,134 |  |  |  | 28,448 |  |  |  | — |  |  |  | — |
Change in Fair Value of Derivative Liabilities | The change in the fair value of derivative liabilities for the years ended December 31, 2015 and 2014 is as follows (in thousands):
|  | October 2009 Warrants |  |  | Long-Term Debt Derivative Liabilities |  |  | Preferred Stock Purchase Option |  |  | Total |
Balance as of January 1, 2014 |  | $ | 6,894 |  |  | $ | 11,100 |  |  | $ | — |  |  | $ | 17,994 |
Record initial fair value of derivative liability on 2014 Notes |  |  | — |  |  |  | 3,500 |  |  |  | — |  |  |  | 3,500 |
Gain on change in fair value of derivative liabilities |  |  | (6,272 | ) |  |  | (7,200 | ) |  |  | — |  |  |  | (13,472 | )
Compensation income for change in fair value of warrants issued to former employees |  |  | (503 | ) |  |  | — |  |  |  | — |  |  |  | (503 | )
Balance as of December 31, 2014 |  | $ | 119 |  |  | $ | 7,400 |  |  | $ | — |  |  | $ | 7,519 |
Record initial fair value of derivative liability |  |  | — |  |  |  | 500 |  |  |  | 868 |  |  |  | 1,368 |
(Gain) loss on change in fair value of derivative liabilities |  |  | (110 | ) |  |  | 270 |  |  |  | 946 |  |  |  | 1,106 |
Compensation income for change in fair value of warrants issued to former employees |  |  | (9 | ) |  |  | — |  |  |  | — |  |  |  | (9 | )
Transfer derivative liability to equity |  |  | — |  |  |  | — |  |  |  | (1,814 | ) |  |  | (1,814 | )
Balance as of December 31, 2015 |  | $ | — |  |  | $ | 8,170 |  |  | $ | — |  |  | $ | 8,170 |

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