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Debt - Additional Information (Detail) |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | ---
Dec. 06, 2012 USD ($) | Nov. 30, 2015 USD ($) shares $ / shares | May. 31, 2014 USD ($) shares d $ / shares | Jan. 31, 2012 USD ($) shares $ / shares | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) | Dec. 31, 2013 USD ($)
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  |  |  | $ (1,106,000) | $ 13,472,000 | $ 47,710,000
Interest expense |  |  |  |  | 20,180,000 | 18,575,000 | $ 34,179,000
Proceeds from issuance of convertible debt, net of transaction costs |  |  |  |  | 27,514,000 |  |
Carrying amount of debt conversion option over the liability component |  |  |  |  | 11,500,000 | 12,800,000 |
Decrease to additional paid-in capital for repurchase of conversion option in convertible notes |  |  |  |  | 1,300,000 | 10,100,000 |
Gain on extinguishment of debt |  |  |  |  | 1,314,000 | 38,034,000 |
Convertible senior notes, repayment |  |  |  |  | 16,145,000 |  |
Convertible Debt |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Convertible notes, interest expense |  |  |  |  | 11,400,000 | 9,500,000 |
Non-cash interest expense |  |  |  |  | 6,200,000 | 4,200,000 |
Interest expense, contractual coupon interest accrual |  |  |  |  | 5,200,000 | 5,300,000 |
Accrued interest on convertible note |  |  |  |  | 2,300,000 | 2,400,000 |
Convertible Debt | 2012 Notes |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, principal amount |  | $ 15,100,000 | $ 31,300,000 | $ 150,000,000 |  |  |
Convertible senior notes, stated interest rate |  |  |  | 3.50% |  |  |
Convertible senior notes, due date |  |  |  | 2032 |  |  |
Proceeds from issuance of convertible debt, net of transaction costs |  |  |  | $ 144,300,000 |  |  |
Convertible senior notes, payment start date |  |  |  | Jul. 15, 2012 |  |  |
Convertible senior notes, maturity date |  |  |  | Jan. 15, 2032 |  |  |
Value of shares in excess of principal amount of Notes based on closing price |  |  |  |  | 11,900,000 |  |
Additional interest rate on notes per annum |  |  |  | 0.50% |  |  |
Convertible senior notes, repurchase price at option of the issuer |  |  |  | 100.00% |  |  |
Carrying amount of debt conversion option over the liability component |  |  |  | $ 23,800,000 |  |  |
Convertible senior notes, fair value |  |  |  |  | 13,637,000 | 25,689,000 |
Note, estimated remaining life |  |  |  | 24 months |  |  |
Debt discount amortization period |  |  |  | 24 months |  |  |
Convertible notes, carrying amount net of unamortized discount |  |  |  |  | 15,100,000 | 31,300,000 |
Decrease to additional paid-in capital for repurchase of conversion option in convertible notes |  |  | 10,100,000 |  |  |  |
Convertible senior notes, discount |  |  |  |  | 0 | 0 |
Gain on extinguishment of debt |  | 1,300,000 | 38,000,000 |  |  |  |
Convertible senior notes, repayment |  | 15,900,000 |  |  |  |  |
Convertible senior notes, principal amount purchase |  | 16,200,000 |  |  |  |  |
Convertible senior notes, purchase amount |  | 15,900,000 |  |  |  |  |
Convertible Debt | 2012 Notes | American Depository Shares |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  |  |  | 113.4752 |  |  |
Convertible senior notes, total ADS into which the debt is exchangeable | shares |  |  |  | 1,714,270 |  |  |
Convertible senior notes, initial exchange price | $ / shares |  |  |  | $ 8.8125 |  |  |
Convertible Debt | 2012 Notes | Exchanged Debt |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, principal amount |  |  | 118,700,000 |  |  |  |
Convertible Debt | 2014 Notes |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Fair value of embedded derivative liability |  |  |  |  | 2,100,000 | 2,600,000 |
Gain (Loss) on change in fair value of derivative liability |  |  |  |  | 500,000 | 900,000 |
Convertible senior notes, principal amount |  |  | $ 118,700,000 |  |  |  |
Convertible senior notes, stated interest rate |  |  | 3.50% |  |  |  |
Convertible senior notes, due date |  |  | 2032 |  |  |  |
Convertible senior notes, payment start date |  |  | Jul. 15, 2014 |  |  |  |
Convertible senior notes, maturity date |  |  | Jan. 15, 2032 |  |  |  |
Value of shares in excess of principal amount of Notes based on closing price |  |  |  |  | 32,400,000 |  |
Convertible senior notes, repurchase price at option of the issuer |  |  | 100.00% |  |  |  |
Convertible senior notes, fair value |  |  | $ 90,800,000 |  | 108,034,000 | 75,533,000 |
Convertible notes, carrying amount net of unamortized discount |  |  |  |  | 96,400,000 | 90,600,000 |
Convertible senior notes redemption, end date |  |  | Jan. 15, 2032 |  |  |  |
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, in any number of VWAP Trading days | d |  |  | 30 |  |  |  |
Convertible senior notes, discount |  |  | $ 27,900,000 |  |  |  |
Offering costs |  |  | 2,500,000 |  |  |  |
Derivative liability at fair value |  |  | $ 3,500,000 |  |  |  |
Convertible Debt | 2014 Notes | American Depository Shares |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  |  | 384.6154 |  |  |  |
Convertible senior notes, total ADS into which the debt is exchangeable | shares |  |  | 45,666,925 |  |  |  |
Convertible senior notes, initial exchange price | $ / shares |  |  | $ 2.60 |  |  |  |
Convertible Debt | 2014 Notes | Minimum |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price |  |  | 110.00% |  |  |  |
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, at least number of VWAP Trading days |  |  | 20 days |  |  |  |
Convertible Debt | 2015 Notes |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Fair value of embedded derivative liability |  |  |  |  | 600,000 |  |
Gain (Loss) on change in fair value of derivative liability |  |  |  |  | (100,000) |  |
Convertible senior notes, principal amount |  | $ 31,300,000 |  |  |  |  |
Convertible senior notes, stated interest rate |  | 3.50% |  |  |  |  |
Convertible senior notes, due date |  | 2032 |  |  |  |  |
Proceeds from issuance of convertible debt, net of transaction costs |  | $ 27,500,000 |  |  |  |  |
Convertible senior notes, payment start date |  | Jan. 15, 2016 |  |  |  |  |
Convertible senior notes, maturity date |  | Jan. 15, 2032 |  |  |  |  |
Value of shares in excess of principal amount of Notes based on closing price |  |  |  |  | 8,500,000 |  |
Convertible senior notes, fair value |  | $ 27,500,000 |  |  | 28,448,000 |  |
Convertible notes, carrying amount net of unamortized discount |  |  |  |  | 27,100,000 |  |
Convertible senior notes, discount |  | 3,800,000 |  |  |  |  |
Offering costs |  | 100,000 |  |  |  |  |
Derivative liability at fair value |  | $ 500,000 |  |  |  |  |
Convertible notes, interest expense |  |  |  |  | 200,000 |  |
Non-cash interest expense |  |  |  |  | 100,000 |  |
Interest expense, contractual coupon interest accrual |  |  |  |  | 100,000 |  |
Convertible Debt | 2015 Notes | American Depository Shares |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes |  | 384.6154 |  |  |  |  |
Convertible senior notes, total ADS into which the debt is exchangeable | shares |  | 12,025,385 |  |  |  |  |
Convertible senior notes, initial exchange price | $ / shares |  | $ 2.60 |  |  |  |  |
Convertible Debt | 2015 Notes | Minimum |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Beneficial ownership limitation |  | 4.99% |  |  |  |  |
Convertible Debt | 2015 Notes | Maximum |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Beneficial ownership limitation |  | 19.90% |  |  |  |  |
Convertible Debt | Other debt outstanding | 2012 Notes |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, fair value |  |  |  | $ 126,200,000 |  |  |
Convertible Debt | Non Cash | 2014 Notes |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  | 22,400,000 | 28,200,000 |
Convertible Debt | Non Cash | 2015 Notes |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  | 4,100,000 |  |
Biopharma Debt |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Amount received at the closing of the agreement | $ 100,000,000 |  |  |  |  |  |
Maximum repayment of future revenue and receivables | 150,000,000 |  |  |  | 137,300,000 |  |
Repayment under agreement |  |  |  |  | 7,100,000 |  |
Fair value of embedded derivative liability | $ 14,600,000 |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  |  |  | (700,000) | 6,300,000 |
Biopharma Debt | February 2016 |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Future minimum repayment under agreement |  |  |  |  | 2,600,000 |  |
Biopharma Debt | Second quarter of 2016 and in each of the next three quarters |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Future minimum repayment under agreement |  |  |  |  | 15,000,000 |  |
Biopharma Debt | May 2017 |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Future minimum repayment under agreement |  |  |  |  | 13,000,000 |  |
Biopharma Debt | Cash |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Interest expense |  |  |  |  | 6,600,000 | 7,200,000 |
Biopharma Debt | Non Cash |  |  |  |  |  |  |
Debt Disclosure [Line Items] |  |  |  |  |  |  |
Interest expense |  |  |  |  | $ 1,900,000 | $ 1,900,000 |

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- Definition The amount of debt discount that was originally recognized at the issuance of the instrument that has yet to be amortized. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 30 -Section 45 -Paragraph 1A -URI http://asc.fasb.org/extlink&oid=6451184&loc=d3e28541-108399 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 30 -Section 55 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=34725769&loc=d3e28878-108400 + Details
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- Definition Fair value, before effects of master netting arrangements, of a financial liability or contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset. Includes liabilities elected not to be offset. Excludes liabilities not subject to a master netting arrangement. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 860 -SubTopic 20 -Section 50 -Paragraph 4D -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=51814546&loc=SL51823488-111719 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 20 -Section 50 -Paragraph 3 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=51824906&loc=SL20225862-175312 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 815 -SubTopic 10 -Section 50 -Paragraph 4B -Subparagraph (a),(c) -URI http://asc.fasb.org/extlink&oid=56946850&loc=SL5624163-113959 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 20 -Section 55 -Paragraph 7 -URI http://asc.fasb.org/extlink&oid=51825145&loc=SL20226000-175313 + Details
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- Definition Difference between the fair value of payments made and the carrying amount of debt which is extinguished prior to maturity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 50 -Section 40 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=49170532&loc=d3e12317-112629 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 50 -Section 40 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=49170532&loc=d3e12355-112629 + Details
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