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Significant Accounting Policies - Additional Information (Detail) |  |  | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Feb. 27, 2015 shares | Oct. 16, 2009 | Dec. 31, 2015 USD ($) Tranche Segment shares | Dec. 31, 2014 USD ($) shares | Dec. 31, 2013 USD ($) | Nov. 30, 2015 USD ($) | Mar. 05, 2015 USD ($) | May. 31, 2014 USD ($) | Dec. 31, 2012 USD ($) | Dec. 06, 2012 USD ($)
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Deferred revenue, current |  |  | $ 923,000 |  | $ 1,700,000 |  |  |  |  |
Sales discount percentage |  |  | 2.00% |  |  |  |  |  |  |
Sales discount term |  |  | 30 days |  |  |  |  |  |  |
Trade receivables, credit period |  |  | 30 days |  |  |  |  |  |  |
Number of tranches for private placement transaction | Tranche |  |  | 2 |  |  |  |  |  |  |
Accounts receivable written off |  |  | $ 0 |  |  |  |  |  |  |
Warrants outstanding | shares |  |  | 0 |  |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  | $ (1,106,000) | $ 13,472,000 | $ 47,710,000 |  |  |  |  |
Number of operating segments | Segment |  |  | 1 |  |  |  |  |  |  |
Biopharma Debt |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  | $ (700,000) | 6,300,000 |  |  |  |  |  |
Maximum repayment of future revenue and receivables |  |  | 137,300,000 |  |  |  |  |  |  | $ 150,000,000
Fair value of embedded derivative liability |  |  |  |  |  |  |  |  |  | $ 14,600,000
Embedded Derivative Financial Instruments |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  | (270,000) | 7,200,000 |  |  |  |  |  |
Embedded Derivative Financial Instruments | Biopharma Debt |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  | (700,000) | 6,300,000 |  |  |  |  |  |
Maximum repayment of future revenue and receivables |  |  |  |  |  |  |  |  | $ 150,000,000 |
Fair value of embedded derivative liability |  |  | 5,500,000 | $ 4,800,000 |  |  |  |  |  |
Preferred Stock Purchase Option |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  | $ (946,000) |  |  |  |  |  |  |
Derivative liability at fair value |  |  |  |  |  |  | $ 900,000 |  |  |
Top Three Customers | Gross Product Sales | Customer Concentration Risk |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Concentration risk percentage |  |  | 95.00% | 95.00% |  |  |  |  |  |
Top Three Customers | Accounts Receivable | Customer Concentration Risk |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Concentration risk percentage |  |  | 95.00% | 96.00% |  |  |  |  |  |
Convertible Debt | 2014 Notes |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  |  |  |  | $ 27,900,000 |  |
Derivative liability fair value assumptions, risk-free rate |  |  |  | 2.70% |  |  |  |  |  |
Derivative liability fair value assumptions, dividend yield |  |  |  | 24.80% |  |  |  |  |  |
Derivative liability fair value assumptions, volatility rate |  |  |  | 82.00% |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  | $ 500,000 | $ 900,000 |  |  |  |  |  |
Fair value of embedded derivative liability |  |  | 2,100,000 | $ 2,600,000 |  |  |  |  |  |
Derivative liability at fair value |  |  |  |  |  |  |  | $ 3,500,000 |  |
Convertible Debt | 2015 Notes |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  |  |  |  | $ 3,800,000 |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  | (100,000) |  |  |  |  |  |  |
Fair value of embedded derivative liability |  |  | $ 600,000 |  |  |  |  |  |  |
Derivative liability at fair value |  |  |  |  |  | $ 500,000 |  |  |  |
Convertible Debt | 2014 Notes and 2015 Notes |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Derivative liability fair value assumptions, risk-free rate |  |  | 2.90% | 2.70% |  |  |  |  |  |
Derivative liability fair value assumptions, dividend yield |  |  | 25.60% | 24.80% |  |  |  |  |  |
Derivative liability fair value assumptions, volatility rate |  |  | 89.00% | 82.00% |  |  |  |  |  |
Convertible Debt | 2012 Notes |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  | $ 0 | $ 0 |  |  |  |  |  |
Convertible Debt | Non Cash | 2014 Notes |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  | 22,400,000 | $ 28,200,000 |  |  |  |  |  |
Convertible Debt | Non Cash | 2015 Notes |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Convertible senior notes, discount |  |  | $ 4,100,000 |  |  |  |  |  |  |
Warrants Issued October 2009 |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Warrants expiration date |  |  | Feb. 27, 2015 |  |  |  |  |  |  |
Warrants outstanding | shares |  |  | 0 | 8,087,388 |  |  |  |  |  |
Warrants exercised | shares |  |  | 1,844,585 |  |  |  |  |  |  |
Warrants expired | shares | 6,242,803 |  |  |  |  |  |  |  |  |
Warrant derivative liability |  |  |  | $ 100,000 |  |  |  |  |  |
Derivative liability fair value assumptions, risk-free rate |  |  |  | 0.04% |  |  |  |  |  |
Derivative liability fair value assumptions, term |  |  |  | 1 month 28 days |  |  |  |  |  |
Derivative liability fair value assumptions, dividend yield |  |  |  | 0.00% |  |  |  |  |  |
Derivative liability fair value assumptions, volatility rate |  |  |  | 79.00% |  |  |  |  |  |
Gain (Loss) on change in fair value of derivative liability |  |  | $ 110,000 |  |  |  |  |  |  |
Decrease in fair value of warrants |  |  | $ 100,000 |  |  |  |  |  |  |
Warrants Issued October 2009 | Prior To Agreement |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Warrants expiration date |  | Oct. 16, 2014 |  |  |  |  |  |  |  |
Maximum | Embedded Derivative Financial Instruments | Biopharma Debt |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Derivative liability fair value assumptions, term |  |  | 7 years 3 months 18 days | 3 years 7 months 6 days |  |  |  |  |  |
Derivative liability fair value assumption, coupon rate |  |  | 12.50% | 10.80% |  |  |  |  |  |
Derivative liability fair value assumptions, market yields |  |  | 30.70% | 16.80% |  |  |  |  |  |
Minimum | Embedded Derivative Financial Instruments | Biopharma Debt |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Derivative liability fair value assumptions, term |  |  | 2 years | 2 years 3 months 18 days |  |  |  |  |  |
Derivative liability fair value assumption, coupon rate |  |  | 6.60% | 9.80% |  |  |  |  |  |
Derivative liability fair value assumptions, market yields |  |  | 13.00% | 10.00% |  |  |  |  |  |

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