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Related Party Transaction - Additional Information (Detail) |  |  |  | 1 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Jul. 10, 2015 USD ($) $ / shares shares | Mar. 05, 2015 shares | Oct. 16, 2009 shares | Oct. 31, 2009 Point shares | Dec. 31, 2015 USD ($) $ / shares shares | Dec. 31, 2014 USD ($) shares | Dec. 31, 2013 USD ($)
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Derivative liability | $ |  |  |  |  | $ 8,170,000 | $ 7,519,000 | $ 17,994,000
Preferred stock, equivalent ordinary shares upon future consolidation |  |  |  |  | 32,818,464 | 0 |
American Depository Shares | Series A Preferred Stock |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Purchase of ADSs (in the form of common stock) by directors in private placement |  | 352,150,790 |  |  |  |  |
Preferred Shares Basis |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Share conversion price | $ / shares |  |  |  |  | $ 0.15 |  |
Ordinary Shares Basis |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Share conversion price | $ / shares |  |  |  |  | $ 1.50 |  |
October 2009 Private Placement |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Purchase of ADSs (in the form of common stock) by directors in private placement |  |  | 66,400,000 |  |  |  |
October 2009 Private Placement | Warrant |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Derivative liability | $ |  |  |  |  | $ 0 |  |
Derivative liability at fair value | $ |  |  |  |  | $ 0 |  |
October 2009 Private Placement | American Depository Shares |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Purchase of ADSs (in the form of common stock) by directors in private placement |  |  |  | 36,000,000 |  |  |
Number of ADS that can be purchased for each warrant received | Point |  |  |  | 0.5 |  |  |
October 2009 Private Placement | American Depository Shares | Abingworth LLP |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Purchase of ADSs (in the form of common stock) by directors in private placement |  |  |  | 17,000,000 |  |  |
October 2009 Private Placement | American Depository Shares | Orbimed Advisors LLC |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Purchase of ADSs (in the form of common stock) by directors in private placement |  |  |  | 7,000,000 |  |  |
October 2009 Private Placement | American Depository Shares | Sofinnova Venture Partners VII, LP |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Purchase of ADSs (in the form of common stock) by directors in private placement |  |  |  | 7,000,000 |  |  |
October 2009 Private Placement | American Depository Shares | Fountain Healthcare Partners Fund 1, LP |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Purchase of ADSs (in the form of common stock) by directors in private placement |  |  |  | 5,000,000 |  |  |
Second Private Placement | Series A Preferred Stock |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Preferred stock, equivalent ordinary shares upon future consolidation | 3,886,718 |  |  |  |  |  |
Subscription agreement to purchase Additional shares | $ | $ 5,800,000 |  |  |  |  |  |
Second Private Placement | American Depository Shares | Series A Preferred Stock |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Purchase of ADSs (in the form of common stock) by directors in private placement | 38,867,180 |  |  |  |  |  |
Second Private Placement | Preferred Shares Basis | Series A Preferred Stock |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Share conversion price | $ / shares | $ 0.15 |  |  |  |  |  |
Second Private Placement | Ordinary Shares Basis | Series A Preferred Stock |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Share conversion price | $ / shares | $ 1.50 |  |  |  |  |  |

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