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Commitments and Contingencies - Additional Information (Detail) |  |  |  |  |  |  |  | 12 Months Ended |  |  |  |
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Jun. 30, 2015 ft² | Jan. 31, 2015 ft² | Apr. 30, 2014 ft² | Jan. 31, 2014 ft² | May. 08, 2013 ft² | Dec. 15, 2012 ft² | Dec. 06, 2011 ft² | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) | Dec. 31, 2013 USD ($) | Dec. 31, 2015 GBP (£) | Nov. 01, 2013 USD ($) ft² | Nov. 01, 2013 EUR (€) ft² | Sep. 30, 2011 ft² | Jul. 01, 2011 ft²
Commitments and Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating lease, rental expense | $ |  |  |  |  |  |  |  | $ 800,000 | $ 1,000,000 | $ 1,000,000 |  |  |  |  |
Potential payable amount over the agreement terms based on minimum purchase obligation | $ |  |  |  |  |  |  |  | $ 44,700,000 |  |  |  |  |  |  |
Dublin |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments and Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Office space leased (in square feet) |  |  |  |  |  |  |  |  |  |  |  | 270 | 270 | 320 |
Operating lease, expiration date |  |  |  |  |  |  |  | Oct. 31, 2016 |  |  |  |  |  |  |
Operating lease, renewal option |  |  |  |  |  |  |  | 1 year |  |  |  |  |  |  |
Operating lease, monthly rent |  |  |  |  |  |  |  |  |  |  |  | $ 3,200 | € 2,900 |  |
Bedminster |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments and Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Office space leased (in square feet) |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9,747
Operating lease, expiration date |  |  |  |  |  |  |  | Mar. 31, 2018 |  |  |  |  |  |  |
Additional office space leased (in square feet) |  |  |  |  | 10,883 | 2,601 | 2,142 |  |  |  |  |  |  |  |
Square feet vacated in exchange for reduction on future rent payments |  |  | 2,000 | 2,142 |  |  |  |  |  |  |  |  |  |  |
Sublease | Bedminster |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments and Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional office space leased under sublease (in square feet) | 2,500 | 4,700 |  |  |  |  |  |  |  |  |  |  |  |  |
Further Indication for AMR101 | Laxdale Limited | Potential Marketing Approval 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments and Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential aggregate stock or cash payment |  |  |  |  |  |  |  | $ 7,400,000 |  |  | £ 5,000,000 |  |  |  |
Further Indication for AMR101 | Laxdale Limited | Potential Marketing Approval 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments and Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential aggregate stock or cash payment |  |  |  |  |  |  |  | 7,400,000 |  |  | 5,000,000 |  |  |  |
Further Indication for AMR101 | Laxdale Limited | Marketing Approval In Europe |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments and Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential aggregate stock or cash payment |  |  |  |  |  |  |  | 11,100,000 |  |  | 7,500,000 |  |  |  |
Further Indication for AMR101 | Laxdale Limited | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commitments and Contingencies Disclosure [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential aggregate stock or cash payment |  |  |  |  |  |  |  | $ 14,800,000 |  |  | £ 10,000,000 |  |  |  |

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