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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Product revenue, net $ 80,987 $ 54,202 $ 26,351
Licensing revenue 769    
Total revenue, net 81,756 54,202 26,351
Less: Cost of goods sold 27,875 20,485 11,912
Gross margin 53,881 33,717 14,439
Operating expenses:      
Selling, general and administrative 101,041 79,346 123,795
Research and development 51,062 50,326 72,750
Total operating expenses 152,103 129,672 196,545
Operating loss (98,222) (95,955) (182,106)
(Loss) gain on change in fair value of derivative liabilities (1,106) 13,472 47,710
Gain on extinguishment of debt 1,314 38,034  
Interest expense (20,180) (18,575) (34,179)
Interest income 132 96 343
Other (expense) income, net (228) 3,727 (1,189)
Loss from operations before taxes (118,290) (59,201) (169,421)
Benefit from income taxes 3,086 2,837 3,194
Net loss (115,204) (56,364) (166,227)
Preferred stock purchase option (868)    
Preferred stock beneficial conversion features (32,987)    
Net loss applicable to common shareholders $ (149,059) $ (56,364) $ (166,227)
Loss per share:      
Basic $ (0.83) $ (0.32) $ (1.03)
Diluted $ (0.83) $ (0.36) $ (1.28)
Weighted average shares:      
Basic 180,654 173,719 161,022
Diluted 180,654 173,824 167,070