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Debt - Additional Information (Detail)
 1 Months Ended 12 Months Ended
Dec. 06, 2012
USD ($)
Nov. 30, 2015
USD ($)
shares
$ / shares
May. 31, 2014
USD ($)
shares
d
$ / shares
Jan. 31, 2012
USD ($)
shares
$ / shares
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Debt Disclosure [Line Items]              
Gain (Loss) on change in fair value of derivative liability         $ (1,106,000) $ 13,472,000 $ 47,710,000
Interest expense         20,180,000 18,575,000 $ 34,179,000
Proceeds from issuance of convertible debt, net of transaction costs         27,514,000    
Carrying amount of debt conversion option over the liability component         11,500,000 12,800,000  
Decrease to additional paid-in capital for repurchase of conversion option in convertible notes         1,300,000 10,100,000  
Gain on extinguishment of debt         1,314,000 38,034,000  
Convertible senior notes, repayment         16,145,000    
Convertible Debt              
Debt Disclosure [Line Items]              
Convertible notes, interest expense         11,400,000 9,500,000  
Non-cash interest expense         6,200,000 4,200,000  
Interest expense, contractual coupon interest accrual         5,200,000 5,300,000  
Accrued interest on convertible note         2,300,000 2,400,000  
Convertible Debt | 2012 Notes              
Debt Disclosure [Line Items]              
Convertible senior notes, principal amount   $ 15,100,000 $ 31,300,000 $ 150,000,000      
Convertible senior notes, stated interest rate       3.50%      
Convertible senior notes, due date       2032      
Proceeds from issuance of convertible debt, net of transaction costs       $ 144,300,000      
Convertible senior notes, payment start date       Jul. 15, 2012      
Convertible senior notes, maturity date       Jan. 15, 2032      
Value of shares in excess of principal amount of Notes based on closing price         11,900,000    
Additional interest rate on notes per annum       0.50%      
Convertible senior notes, repurchase price at option of the issuer       100.00%      
Carrying amount of debt conversion option over the liability component       $ 23,800,000      
Convertible senior notes, fair value         13,637,000 25,689,000  
Note, estimated remaining life       24 months      
Debt discount amortization period       24 months      
Convertible notes, carrying amount net of unamortized discount         15,100,000 31,300,000  
Decrease to additional paid-in capital for repurchase of conversion option in convertible notes     10,100,000        
Convertible senior notes, discount         0 0  
Gain on extinguishment of debt   1,300,000 38,000,000        
Convertible senior notes, repayment   15,900,000          
Convertible senior notes, principal amount purchase   16,200,000          
Convertible senior notes, purchase amount   15,900,000          
Convertible Debt | 2012 Notes | American Depository Shares              
Debt Disclosure [Line Items]              
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes       113.4752      
Convertible senior notes, total ADS into which the debt is exchangeable | shares       1,714,270      
Convertible senior notes, initial exchange price | $ / shares       $ 8.8125      
Convertible Debt | 2012 Notes | Exchanged Debt              
Debt Disclosure [Line Items]              
Convertible senior notes, principal amount     118,700,000        
Convertible Debt | 2014 Notes              
Debt Disclosure [Line Items]              
Fair value of embedded derivative liability         2,100,000 2,600,000  
Gain (Loss) on change in fair value of derivative liability         500,000 900,000  
Convertible senior notes, principal amount     $ 118,700,000        
Convertible senior notes, stated interest rate     3.50%        
Convertible senior notes, due date     2032        
Convertible senior notes, payment start date     Jul. 15, 2014        
Convertible senior notes, maturity date     Jan. 15, 2032        
Value of shares in excess of principal amount of Notes based on closing price         32,400,000    
Convertible senior notes, repurchase price at option of the issuer     100.00%        
Convertible senior notes, fair value     $ 90,800,000   108,034,000 75,533,000  
Convertible notes, carrying amount net of unamortized discount         96,400,000 90,600,000  
Convertible senior notes redemption, end date     Jan. 15, 2032        
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, in any number of VWAP Trading days | d     30        
Convertible senior notes, discount     $ 27,900,000        
Offering costs     2,500,000        
Derivative liability at fair value     $ 3,500,000        
Convertible Debt | 2014 Notes | American Depository Shares              
Debt Disclosure [Line Items]              
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes     384.6154        
Convertible senior notes, total ADS into which the debt is exchangeable | shares     45,666,925        
Convertible senior notes, initial exchange price | $ / shares     $ 2.60        
Convertible Debt | 2014 Notes | Minimum              
Debt Disclosure [Line Items]              
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price     110.00%        
Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, at least number of VWAP Trading days     20 days        
Convertible Debt | 2015 Notes              
Debt Disclosure [Line Items]              
Fair value of embedded derivative liability         600,000    
Gain (Loss) on change in fair value of derivative liability         (100,000)    
Convertible senior notes, principal amount   $ 31,300,000          
Convertible senior notes, stated interest rate   3.50%          
Convertible senior notes, due date   2032          
Proceeds from issuance of convertible debt, net of transaction costs   $ 27,500,000          
Convertible senior notes, payment start date   Jan. 15, 2016          
Convertible senior notes, maturity date   Jan. 15, 2032          
Value of shares in excess of principal amount of Notes based on closing price         8,500,000    
Convertible senior notes, fair value   $ 27,500,000     28,448,000    
Convertible notes, carrying amount net of unamortized discount         27,100,000    
Convertible senior notes, discount   3,800,000          
Offering costs   100,000          
Derivative liability at fair value   $ 500,000          
Convertible notes, interest expense         200,000    
Non-cash interest expense         100,000    
Interest expense, contractual coupon interest accrual         100,000    
Convertible Debt | 2015 Notes | American Depository Shares              
Debt Disclosure [Line Items]              
Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes   384.6154          
Convertible senior notes, total ADS into which the debt is exchangeable | shares   12,025,385          
Convertible senior notes, initial exchange price | $ / shares   $ 2.60          
Convertible Debt | 2015 Notes | Minimum              
Debt Disclosure [Line Items]              
Beneficial ownership limitation   4.99%          
Convertible Debt | 2015 Notes | Maximum              
Debt Disclosure [Line Items]              
Beneficial ownership limitation   19.90%          
Convertible Debt | Other debt outstanding | 2012 Notes              
Debt Disclosure [Line Items]              
Convertible senior notes, fair value       $ 126,200,000      
Convertible Debt | Non Cash | 2014 Notes              
Debt Disclosure [Line Items]              
Convertible senior notes, discount         22,400,000 28,200,000  
Convertible Debt | Non Cash | 2015 Notes              
Debt Disclosure [Line Items]              
Convertible senior notes, discount         4,100,000    
Biopharma Debt              
Debt Disclosure [Line Items]              
Amount received at the closing of the agreement $ 100,000,000            
Maximum repayment of future revenue and receivables 150,000,000       137,300,000    
Repayment under agreement         7,100,000    
Fair value of embedded derivative liability $ 14,600,000            
Gain (Loss) on change in fair value of derivative liability         (700,000) 6,300,000  
Biopharma Debt | February 2016              
Debt Disclosure [Line Items]              
Future minimum repayment under agreement         2,600,000    
Biopharma Debt | Second quarter of 2016 and in each of the next three quarters              
Debt Disclosure [Line Items]              
Future minimum repayment under agreement         15,000,000    
Biopharma Debt | May 2017              
Debt Disclosure [Line Items]              
Future minimum repayment under agreement         13,000,000    
Biopharma Debt | Cash              
Debt Disclosure [Line Items]              
Interest expense         6,600,000 7,200,000  
Biopharma Debt | Non Cash              
Debt Disclosure [Line Items]              
Interest expense         $ 1,900,000 $ 1,900,000