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Commitments and Contingencies - Additional Information (Detail)
 12 Months Ended
Jun. 30, 2015
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Jan. 31, 2015
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Apr. 30, 2014
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Jan. 31, 2014
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May. 08, 2013
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Dec. 15, 2012
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Dec. 06, 2011
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Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Dec. 31, 2015
GBP (£)
Nov. 01, 2013
USD ($)
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Nov. 01, 2013
EUR (€)
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Sep. 30, 2011
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Jul. 01, 2011
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Commitments and Contingencies Disclosure [Line Items]                              
Operating lease, rental expense | $               $ 800,000 $ 1,000,000 $ 1,000,000          
Potential payable amount over the agreement terms based on minimum purchase obligation | $               $ 44,700,000              
Dublin                              
Commitments and Contingencies Disclosure [Line Items]                              
Office space leased (in square feet)                       270 270 320  
Operating lease, expiration date               Oct. 31, 2016              
Operating lease, renewal option               1 year              
Operating lease, monthly rent                       $ 3,200 € 2,900    
Bedminster                              
Commitments and Contingencies Disclosure [Line Items]                              
Office space leased (in square feet)                             9,747
Operating lease, expiration date               Mar. 31, 2018              
Additional office space leased (in square feet)         10,883 2,601 2,142                
Square feet vacated in exchange for reduction on future rent payments     2,000 2,142                      
Sublease | Bedminster                              
Commitments and Contingencies Disclosure [Line Items]                              
Additional office space leased under sublease (in square feet) 2,500 4,700                          
Further Indication for AMR101 | Laxdale Limited | Potential Marketing Approval 1                              
Commitments and Contingencies Disclosure [Line Items]                              
Potential aggregate stock or cash payment               $ 7,400,000     £ 5,000,000        
Further Indication for AMR101 | Laxdale Limited | Potential Marketing Approval 2                              
Commitments and Contingencies Disclosure [Line Items]                              
Potential aggregate stock or cash payment               7,400,000     5,000,000        
Further Indication for AMR101 | Laxdale Limited | Marketing Approval In Europe                              
Commitments and Contingencies Disclosure [Line Items]                              
Potential aggregate stock or cash payment               11,100,000     7,500,000        
Further Indication for AMR101 | Laxdale Limited | Maximum                              
Commitments and Contingencies Disclosure [Line Items]                              
Potential aggregate stock or cash payment               $ 14,800,000     £ 10,000,000