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Related Party Transaction - Additional Information (Detail)
 1 Months Ended
Jul. 10, 2015
USD ($)
$ / shares
shares
Mar. 05, 2015
shares
Oct. 16, 2009
shares
Oct. 31, 2009
Point
shares
Dec. 31, 2015
USD ($)
$ / shares
shares
Dec. 31, 2014
USD ($)
shares
Dec. 31, 2013
USD ($)
Related Party Transaction [Line Items]              
Derivative liability | $         $ 8,170,000 $ 7,519,000 $ 17,994,000
Preferred stock, equivalent ordinary shares upon future consolidation         32,818,464 0  
American Depository Shares | Series A Preferred Stock              
Related Party Transaction [Line Items]              
Purchase of ADSs (in the form of common stock) by directors in private placement   352,150,790          
Preferred Shares Basis              
Related Party Transaction [Line Items]              
Share conversion price | $ / shares         $ 0.15    
Ordinary Shares Basis              
Related Party Transaction [Line Items]              
Share conversion price | $ / shares         $ 1.50    
October 2009 Private Placement              
Related Party Transaction [Line Items]              
Purchase of ADSs (in the form of common stock) by directors in private placement     66,400,000        
October 2009 Private Placement | Warrant              
Related Party Transaction [Line Items]              
Derivative liability | $         $ 0    
Derivative liability at fair value | $         $ 0    
October 2009 Private Placement | American Depository Shares              
Related Party Transaction [Line Items]              
Purchase of ADSs (in the form of common stock) by directors in private placement       36,000,000      
Number of ADS that can be purchased for each warrant received | Point       0.5      
October 2009 Private Placement | American Depository Shares | Abingworth LLP              
Related Party Transaction [Line Items]              
Purchase of ADSs (in the form of common stock) by directors in private placement       17,000,000      
October 2009 Private Placement | American Depository Shares | Orbimed Advisors LLC              
Related Party Transaction [Line Items]              
Purchase of ADSs (in the form of common stock) by directors in private placement       7,000,000      
October 2009 Private Placement | American Depository Shares | Sofinnova Venture Partners VII, LP              
Related Party Transaction [Line Items]              
Purchase of ADSs (in the form of common stock) by directors in private placement       7,000,000      
October 2009 Private Placement | American Depository Shares | Fountain Healthcare Partners Fund 1, LP              
Related Party Transaction [Line Items]              
Purchase of ADSs (in the form of common stock) by directors in private placement       5,000,000      
Second Private Placement | Series A Preferred Stock              
Related Party Transaction [Line Items]              
Preferred stock, equivalent ordinary shares upon future consolidation 3,886,718            
Subscription agreement to purchase Additional shares | $ $ 5,800,000            
Second Private Placement | American Depository Shares | Series A Preferred Stock              
Related Party Transaction [Line Items]              
Purchase of ADSs (in the form of common stock) by directors in private placement 38,867,180            
Second Private Placement | Preferred Shares Basis | Series A Preferred Stock              
Related Party Transaction [Line Items]              
Share conversion price | $ / shares $ 0.15            
Second Private Placement | Ordinary Shares Basis | Series A Preferred Stock              
Related Party Transaction [Line Items]              
Share conversion price | $ / shares $ 1.50