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Co-Promotion Agreement - Additional Information (Detail)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
USD ($)
Employee
Dec. 31, 2014
USD ($)
Co-Promotion Agreement [Line Items]    
Prepaid and other current assets $ 3,152 $ 2,633
Accrued expenses and other current liabilities $ 24,226 16,387
Co-Promotion Agreement (the Agreement)    
Co-Promotion Agreement [Line Items]    
Promotion fee as a percentage gross margin From the high single digits in 2014 to the low twenty percent level in 2018.  
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America    
Co-Promotion Agreement [Line Items]    
Prepaid and other current assets   $ 600
Accrued expenses and other current liabilities $ 2,500  
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America | Minimum    
Co-Promotion Agreement [Line Items]    
Number of sales representatives | Employee 250