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Nature of Business and Basis of Presentation - Additional Information (Detail) Patient in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2016 USD ($) Segment Patient Employee	Dec. 31, 2015 USD ($)	Mar. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Number of operating segments | Segment	1
REDUCE-IT study, number of patients enrolled | Patient	8
Cash and cash equivalents | $	$ 81,363	$ 106,961	$ 161,195	$ 119,539
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Number of sales professionals	150
Number of sales representatives	250
Convertible Debt | 2012 Notes
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Convertible senior notes, earliest redemption date	Jan. 19, 2017
Convertible Debt | 2014 Notes
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Convertible senior notes, earliest redemption date	Jan. 19, 2019
Convertible Debt | 2015 Notes
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Convertible senior notes, earliest redemption date	Jan. 19, 2019

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Cash
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