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Co-Promotion Agreement - Additional Information (Detail)
$ in Thousands
 3 Months Ended 12 Months Ended
Mar. 31, 2016
USD ($)
Employee
Dec. 31, 2016
Dec. 31, 2015
USD ($)
Co-Promotion Agreement [Line Items]      
Accrued expenses and other current liabilities | $ $ 24,551   $ 24,226
Co-Promotion Agreement (the Agreement)      
Co-Promotion Agreement [Line Items]      
Promotion fee as a percentage of gross margin     15.00%
Promotion fee as a percentage gross margin Scheduled to increase to low twenty percent levels in 2017 and 2018, subject to certain adjustments.    
Co-Promotion Agreement (the Agreement) | Scenario, Forecast      
Co-Promotion Agreement [Line Items]      
Promotion fee as a percentage of gross margin   19.00%  
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America      
Co-Promotion Agreement [Line Items]      
Number of sales representatives | Employee 250    
Accrued expenses and other current liabilities | $ $ 1,100   $ 2,500
Co-Promotion Agreement (the Agreement) | Kowa Pharmaceuticals America | Minimum      
Co-Promotion Agreement [Line Items]      
Number of sales representatives | Employee 250